Phenotypes associated with this allele

• Allele Symbol: oh
• Allele Name: obstructive hydrocephalus
• Allele ID: MGI:1856978
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	oh/oh	Not Specified	MGI:4359280

Genotype
MGI:4359280

hm1

• Allelic Composition: oh/oh
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:23386 )

• affected mice die between 18 and 24 days of age

nervous system

obstructive hydrocephaly ( J:5300 , J:23386 )

• mice develop a generalized ventricular dilation a few days after birth (J:5300)

• flow of cerebralspinal fluid is not impeded in ealy stages of disease (J:5300)

• heads of affected mice become visibly and progressivley enlarged by 3 weeks of age (J:5300)

cerebral aqueductal stenosis ( J:5300 )

• secondary to compression of the midbrain by expanding cerebral hemispheres

• occurs after 2 weeks of age

abnormal brain white matter morphology ( J:5300 )

• hemispheric white matter is severly disrupted

abnormal cerebral cortex morphology ( J:5300 )

growth/size/body

decreased body weight ( J:5300 )

• weight of affected mice fell behind normal siblings after 2 weeks of age

hematopoietic system

increased erythrocyte cell number ( J:5300 )

• scanning EM revealed large numbers on the brain's ventricular surface

increased macrophage cell number ( J:5300 )

• scanning EM revealed large numbers on the brain's ventricular surface

immune system

increased macrophage cell number ( J:5300 )

• scanning EM revealed large numbers on the brain's ventricular surface