mortality/aging
• mice are stillborn or die within hours of birth
|
craniofacial
• angle is reduced
• smaller angle does not allow forward tongue movement under primary palate, therefore obstructs shelf movement
|
• reduced growth seen
(J:7101)
• reduced lower jaw
(J:64447)
|
small maxilla
(
J:7101
)
• reduced growth seen
|
• mice have a large median cleft palate
|
skeleton
• angle is reduced
• smaller angle does not allow forward tongue movement under primary palate, therefore obstructs shelf movement
|
• reduced growth seen
(J:7101)
• reduced lower jaw
(J:64447)
|
small maxilla
(
J:7101
)
• reduced growth seen
|
• mice have numerous abnormalities
|
• mice have numerous abnormalities
|
• transmission EM showed abnormal particle distribution and size on rough endoplasmic reticulum and cell membranes
|
digestive/alimentary system
• mice have a large median cleft palate
|
• intestine length is less than 50% of normal
|
limbs/digits/tail
short limbs
(
J:64447
)
• extreme shortening of extremities
|
growth/size/body
• mice have a large median cleft palate
|