Phenotypes associated with this allele

• Allele Symbol: pf
• Allele Name: pupoid fetus
• Allele ID: MGI:1856990
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	pf/pf	Not Specified	MGI:4398908

Genotype
MGI:4398908

hm1

• Allelic Composition: pf/pf
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality ( J:13424 )

limbs/digits/tail

abnormal forelimb morphology ( J:13424 )

• epidermal overgrowth causes limbs to adhere to body wall during development

abnormal hindlimb morphology ( J:13424 )

• epidermal overgrowth causes limbs to adhere to body wall during development

abnormal tail morphology ( J:13424 )

• epidermal overgrowth causes the tail to adhere to body wall during development

integument

absent hair follicles ( J:13424 )

• noted in late embryos

abnormal skin morphology ( J:13424 )

• the skin of late embryos is stretched in an anteroposterior direction

abnormal dermal layer morphology ( J:7379 )

• the dermis is more cellular than normal

• ectopic cell invasion from the dermis to epidermis can be seen as early as E15-E16

• light and EM microscopy show ectopic cell types including fibroblasts, blood vessels and nerves; a basal lamina is always found between epidermal and invading cells

abnormal epidermal layer morphology ( J:7379 )

• light and EM microscopy show ectopic cell types including fibroblasts, blood vessels and nerves

• ectopic cell invasion from the dermis leads to abnormalities of stratification and keratinization and can be seen as early as E15-E16

• in the 13 day old mouse, this layer varies in thickness between one and ten cell layers

• grafts of heterotypic tissue recombinations result in normal outcomes demonstrating that this mutation is either not skin-specific

abnormal epidermis stratum corneum morphology ( J:7379 )

• replaced by a sparse and discontinuous layer containing unusally small granules

absent epidermis stratum corneum ( J:7379 , J:8835 )

abnormal epidermis stratum granulosum morphology ( J:7379 )

• in the newborn this layer is sparse and discontinuous, containing unusally small granules always in the same location

epidermal hyperplasia ( J:13424 )

thick epidermis ( J:7379 )

• causes limbs and tail to adhere to body wall during development

• in the newborn this layer is very thick compared with normal and has an aberrant, discontinous granular layer containing sparse keratohyalin granules, and an ectopic network of cells including blood vessels and nerves