endocrine/exocrine glands
• glands continue to grow, rather than regress, during active hair growth and remain enlarged to the end of the hair cycle
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integument
• glands continue to grow, rather than regress, during active hair growth and remain enlarged to the end of the hair cycle
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• fur is missing or found in patches and is very short after all hair cycles
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• the first coat is delayed 6 days when short bristles appear on the head and a thick mat of bristles over the body
• distal ends of all hair types are missing
• Background Sensitivity: on other backgrounds scruffiness is replaced by short, irregular hairs
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• a medullated shaft does not form; keratinized material enfolds the hair tip at the level of the sebaceous gland
• abnormalities are due to disturbances to the external root sheath which breaks down prematurely as hair shaft begins to erupt
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• on this background whiskers are entirely absent at birth
• Background Sensitivity: other backgrounds permit some growth
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• thickening of epidermis and dermis are a response to failure of bent hair shafts to erupt normally
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• at 6 days, when the coat normally comes in, the skin is shiny with fine, darkly pigmented wrinkles
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