Phenotypes associated with this allele

• Allele Symbol: ple
• Allele Name: perinatal lethality
• Allele ID: MGI:1856995
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	ple/ple	B6J.Cg-ple	MGI:4410349
hm2	ple/ple	involves: C57BL/6J * CD-1	MGI:4410355

Genotype
MGI:4410349

hm1

• Allelic Composition: ple/ple
• Genetic Background: B6J.Cg-ple

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:9878 )

• Background Sensitivity: on a noninbred background some mice survive

Genotype
MGI:4410355

hm2

• Allelic Composition: ple/ple
• Genetic Background: involves: C57BL/6J * CD-1

mortality/aging

decreased survivor rate ( J:9878 )

• the majority of mutant mice die before 6 months of age

postnatal lethality ( J:9878 )

• Background Sensitivity: fewer than expected homozygous mice are recovered at weaning

• Background Sensitivity: homozygous mice on a C57BL/6J inbred background die soon after birth

growth/size/body

decreased body size ( J:9878 )

• mutant mice are smaller than normal siblings

reproductive system

reduced fertility ( J:9878 )

• only 3% of mutant mice surviving to breed are expected to reproduce