Phenotypes associated with this allele

• Allele Symbol: pr
• Allele Name: porcine tail
• Allele ID: MGI:1857006
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	pr/pr	Not Specified	MGI:4361920

Genotype
MGI:4361920

hm1

• Allelic Composition: pr/pr
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

abnormal tail morphology ( J:12163 )

• tail skeleton preparations show 6 normal caudal vertebrae and 8-15 small vestigial elements

abnormal caudal vertebrae morphology ( J:12163 )

• Background Sensitivity: 8-15 vertebrae may be vestigial

small caudal vertebrae ( J:12163 )

abnormal tail development ( J:12163 )

• Background Sensitivity: unequal growth of the primitive streak causes the tail to grow in a curve dorsally

• Background Sensitivity: the tail defect ranges from a slight bend to extreme loops and coils

• as the affected mouse grows, the tail is pulled into a short coil either to the rigth or left by caudal tendons

short tail ( J:12163 )

• mice with very short tails also display obvious weaving or waltzing behavior

vestigial tail ( J:12163 )

• represents the extreme phenotype among a variation

embryo

abnormal primitive streak formation ( J:12163 )

• unequal growth at the presumptive level of the 7th caudal vertebrae results in tail abnormalities

skeleton

abnormal vestibular aqueduct morphology ( J:12167 )

abnormal temporal bone morphology ( J:12167 )

absent subarcuate fossa ( J:12167 )

• the subarcuate fossa is obliterated affecting the development of the cerebellum

abnormal caudal vertebrae morphology ( J:12163 )

• Background Sensitivity: 8-15 vertebrae may be vestigial

small caudal vertebrae ( J:12163 )

behavior/neurological

weaving ( J:12167 )

• mice with obvious weaving or waltzing behavior also have very short tails

• mice with motor coordination problems also have a characteristic defect in the vestibular aqueduct of at least one ear

hearing/vestibular/ear

abnormal vestibular aqueduct morphology ( J:12167 )

abnormal inner ear vestibule morphology ( J:12167 )

abnormal membranous labyrinth morphology ( J:12167 )

• this structure degenerates in varying degrees

• increased pressure within during development affects cerebellum development

abnormal endolymphatic duct morphology ( J:12167 )

• not present where vestibular aqueduct is abnormal

absent endolymphatic duct ( J:12167 )

• not present where vestibular aqueduct is abnormal

• missing even in mildly affected waltzing mice

absent endolymphatic sac ( J:12167 )

• missing even in mildly affected waltzing mice

craniofacial

abnormal vestibular aqueduct morphology ( J:12167 )

abnormal temporal bone morphology ( J:12167 )

absent subarcuate fossa ( J:12167 )

• the subarcuate fossa is obliterated affecting the development of the cerebellum

nervous system

abnormal cerebellum development ( J:12167 )

• a result of vestibular abnormalities arising during development