Phenotypes associated with this allele

• Allele Symbol: seb
• Allele Name: seborrheic dermatitis
• Allele ID: MGI:1857033
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	seb/seb	Him:OF1	MGI:4359634

Genotype
MGI:4359634

hm1

• Allelic Composition: seb/seb
• Genetic Background: Him:OF1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:64455 )

• preweanling losses are higher than for normal littermates

growth/size/body

postnatal growth retardation ( J:20987 , J:64455 )

• mice are smaller throughout life compared with normal heterozygous controls (J:20987)

reproductive system

small ovary ( J:20987 )

♀

uterus atrophy ( J:20987 )

♀

reduced female fertility ( J:8983 , J:64455 )

♀ (J:8983)

♀ (J:64455)

reduced male fertility ( J:8983 )

♂

immune system

lymph node hyperplasia ( J:20987 )

• of peripheral lymph nodes

lymph node inflammation ( J:20987 )

• predominantly in the cervical region

skin inflammation ( J:8983 )

dermatitis ( J:64455 )

• revealed by histological analysis

endocrine/exocrine glands

sebaceous gland hypertrophy ( J:8983 )

small ovary ( J:20987 )

♀

adipose tissue

decreased total body fat amount ( J:20987 )

homeostasis/metabolism

decreased body temperature ( J:20987 )

increased energy expenditure ( J:20987 )

• mice eat significantly more food compared with normal siblings when metabolic body weight is considered

neoplasm

increased skin tumor incidence ( J:20987 )

• 9 percent of mice develop epithelial tumors which are normally rare, not exceeding 1 percent, in mice in general

decreased tumor incidence ( J:20987 )

• total tumor incidence for the background strain is 84.1 percent for males and 95.9 percent for females; tumor incidence in homozygous mutant males and females is 36.1 percent and 45.0 percent respectively

• most common are lymphomas, osteomas, lung tumors, and neoplasms specific to the female genital tract

integument

sebaceous gland hypertrophy ( J:8983 )

skin inflammation ( J:8983 )

dermatitis ( J:64455 )

• revealed by histological analysis

focal hair loss ( J:64455 )

• around the eyes

hairless ( J:8983 )

• mice may lose their hair before the second hair cycle starts so may be hairless between 3 and 8 weeks of age

premature hair loss ( J:8983 )

• many mice lose their hair before the second hair cycle starts; other hair cycles seem normal

rough coat ( J:64455 )

• affected mice can be identified around 5 days of age; their seemingly normal coat feels rough

greasy coat ( J:64455 )

abnormal hair cycle ( J:8983 )

• many mice lose their hair before the second hair cycle starts; other hair cycles seem normal

• second hair cycle may be delayed

hyperkeratosis ( J:8983 )

parakeratosis ( J:8983 , J:64455 )

• revealed by histological analysis (J:64455)

acanthosis ( J:8983 )

increased skin tumor incidence ( J:20987 )

• 9 percent of mice develop epithelial tumors which are normally rare, not exceeding 1 percent, in mice in general