Phenotypes associated with this allele

• Allele Symbol: sho
• Allele Name: shorthead
• Allele ID: MGI:1857039
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	sho/sho	Not Specified	MGI:3773725

Genotype
MGI:3773725

hm1

• Allelic Composition: sho/sho
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:255 )

• mice die soon after birth

craniofacial

abnormal craniofacial morphology ( J:255 )

abnormal cranium morphology ( J:255 )

• at E14: the chondrocranium is severely foreshortened and the basal plate that will become the presphenoid is widened

large anterior fontanelle ( J:255 )

• in newborns, there is a characteristic saddle-shaped enlargement in the fontanelle between the frontal bones

small frontal bone ( J:255 )

abnormal interfrontal bone morphology ( J:255 )

small presphenoid bone ( J:255 )

abnormal mandible morphology ( J:255 )

small mandible ( J:255 )

small premaxilla ( J:255 )

small maxilla ( J:255 )

abnormal vomer bone morphology ( J:255 )

• two vomer bones are widely separated

abnormal palate bone morphology ( J:255 )

abnormal palatal shelf fusion at midline ( J:13096 )

• evident at E14: abnormally small palatal shelves are prematurely closed

• palatal shelves are prematurely closed anteriorly, partially enclosing the tip of the tongue

cleft secondary palate ( J:255 )

• large median cleft palate

failure of palatal shelf elevation ( J:255 )

• at birth, palatal shelves remain in the original vertical position on either side of the tongue

median cleft palate ( J:255 )

abnormal tongue morphology ( J:255 , J:13096 )

• the tongue is narrower than normal (J:255)

abnormal tongue position ( J:255 , J:13096 )

• the tongue is higher than normal (J:255)

• palatal shelves enclose the tip of the tongue, wedging it close to the roof of the mouse (J:13096)

decreased tongue size ( J:13096 )

• evident at E14

abnormal nose morphology ( J:255 )

small nasal bone ( J:255 )

external nares atresia ( J:255 )

• external nares are closed

shortened head ( J:255 )

• there is disproportionate shortening of the head, evident at E14

embryo

decreased embryo size ( J:255 )

• mutants can be reocognized at 12 days gestation by small size

growth/size/body

abnormal palate bone morphology ( J:255 )

abnormal palatal shelf fusion at midline ( J:13096 )

• evident at E14: abnormally small palatal shelves are prematurely closed

• palatal shelves are prematurely closed anteriorly, partially enclosing the tip of the tongue

cleft secondary palate ( J:255 )

• large median cleft palate

failure of palatal shelf elevation ( J:255 )

• at birth, palatal shelves remain in the original vertical position on either side of the tongue

median cleft palate ( J:255 )

abnormal tongue morphology ( J:255 , J:13096 )

• the tongue is narrower than normal (J:255)

abnormal tongue position ( J:255 , J:13096 )

• the tongue is higher than normal (J:255)

• palatal shelves enclose the tip of the tongue, wedging it close to the roof of the mouse (J:13096)

decreased tongue size ( J:13096 )

• evident at E14

abnormal nose morphology ( J:255 )

small nasal bone ( J:255 )

external nares atresia ( J:255 )

• external nares are closed

shortened head ( J:255 )

• there is disproportionate shortening of the head, evident at E14

decreased embryo size ( J:255 )

• mutants can be reocognized at 12 days gestation by small size

reproductive system

abnormal female reproductive system morphology ( J:255 )

♀

ectopic ovary ( J:255 )

♀ • one ovary may be located medial to the kidney on that side

abnormal oviduct morphology ( J:255 )

♀ • one may occur medially to kidney

endocrine/exocrine glands

small thymus ( J:255 )

• in newborns, the thymus is small and triangular in shape

ectopic ovary ( J:255 )

♀ • one ovary may be located medial to the kidney on that side

limbs/digits/tail

abnormal tail morphology ( J:255 )

• slightly shorter tail with a blunt tip

skeleton

abnormal cranium morphology ( J:255 )

• at E14: the chondrocranium is severely foreshortened and the basal plate that will become the presphenoid is widened

large anterior fontanelle ( J:255 )

• in newborns, there is a characteristic saddle-shaped enlargement in the fontanelle between the frontal bones

small frontal bone ( J:255 )

abnormal interfrontal bone morphology ( J:255 )

small presphenoid bone ( J:255 )

abnormal mandible morphology ( J:255 )

small mandible ( J:255 )

small premaxilla ( J:255 )

small maxilla ( J:255 )

small nasal bone ( J:255 )

abnormal vomer bone morphology ( J:255 )

• two vomer bones are widely separated

abnormal palate bone morphology ( J:255 )

abnormal long bone morphology ( J:255 )

decreased length of long bones ( J:255 )

• forelimbs are more shortened than hindlimbs

• the humerus, radius, ulna, femur, tibia and fibula are all short

sternebra fusion ( J:255 )

• fusions between sternebrae; the number of sternebrae affected is variable

abnormal xiphoid process morphology ( J:255 )

• abnormally shaped and irregular projections occur on both sides

homeostasis/metabolism

cyanosis ( J:255 )

• evident at birth

digestive/alimentary system

abnormal palate bone morphology ( J:255 )

abnormal palatal shelf fusion at midline ( J:13096 )

• evident at E14: abnormally small palatal shelves are prematurely closed

• palatal shelves are prematurely closed anteriorly, partially enclosing the tip of the tongue

cleft secondary palate ( J:255 )

• large median cleft palate

failure of palatal shelf elevation ( J:255 )

• at birth, palatal shelves remain in the original vertical position on either side of the tongue

median cleft palate ( J:255 )

abnormal tongue morphology ( J:255 , J:13096 )

• the tongue is narrower than normal (J:255)

abnormal tongue position ( J:255 , J:13096 )

• the tongue is higher than normal (J:255)

• palatal shelves enclose the tip of the tongue, wedging it close to the roof of the mouse (J:13096)

decreased tongue size ( J:13096 )

• evident at E14

abnormal intestine morphology ( J:255 )

abnormal small intestine morphology ( J:255 )

• small intestine is half normal length

respiratory system

abnormal nose morphology ( J:255 )

small nasal bone ( J:255 )

external nares atresia ( J:255 )

• external nares are closed

cardiovascular system

abnormal heart size ( J:255 )

• in newborns, the heart size varies considerably from normal to either enlarged or reduced

hematopoietic system

small thymus ( J:255 )

• in newborns, the thymus is small and triangular in shape

immune system

small thymus ( J:255 )

• in newborns, the thymus is small and triangular in shape