Analysis Tools|
Allele Symbol Allele Name Allele ID |
Chsy1skt small with kinky tail MGI:1857041 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• homozygotes are smaller than normal with normal proportions
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• only the caudal vertebrae are affected
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in the retina
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• increased number of ectopically localized photoreceptor synapses, increased microglia, and thin outer nuclear layer
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• in the retina
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• in the retina
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• this disruption in the synthesis of chondroitin sulfate glycosaminoglycans is evident in retinal interphotoreceptor matrix and hippocampus
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• significant reduction in neutrophils in the bone marrow but not the spleen
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• diminished numbers of macrophages in the bone marrow and spleen
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• increased transitioning and activated microglia in the retinal outer plexiform layer and outer nuclear layer at 4 weeks and retinal outer nuclear layer and retinal pigment epithelium at 8 weeks of age, and in the hippocampus CA1, CA2, and CA3 at 4 weeks, 8 weeks and 1.5 years of age
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• CD45+ inflammatory cells are found
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• significant reduction in neutrophils in the bone marrow but not the spleen
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• diminished numbers of macrophages in the bone marrow and spleen
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• increased transitioning and activated microglia in the retinal outer plexiform layer and outer nuclear layer at 4 weeks and retinal outer nuclear layer and retinal pigment epithelium at 8 weeks of age, and in the hippocampus CA1, CA2, and CA3 at 4 weeks, 8 weeks and 1.5 years of age
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• develops in older mice
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• increased transitioning and activated microglia in the retinal outer plexiform layer and outer nuclear layer at 4 weeks and retinal outer nuclear layer and retinal pigment epithelium at 8 weeks of age, and in the hippocampus CA1, CA2, and CA3 at 4 weeks, 8 weeks and 1.5 years of age
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• rhodopsin staining shows disrupted outer segment morphology with disorganized and undefined columnar and tip structures
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• at 1.5 years of age an increasing number of empty spaces are found surrounding cells in the CA1, CA2, and CA3 and a loss of wolframin ER transmembrane glycoprotein stained cells
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• rhodopsin staining shows disrupted outer segment morphology with disorganized and undefined columnar and tip structures
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• absent chondroitin sulfate proteoglycans, ectopic synaptic interactions between photoreceptor and bipolar cells, increased apoptosis and progressive photoreceptor cell degeneration
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• scotopic ERG at 8 weeks of age shows decreased a and b wave amplitudes
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• average lifespan of homozygotes is 20 months instead of 27 months
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• found in older mice
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• CD45+ inflammatory cells are found
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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