Phenotypes associated with this allele

• Allele Symbol: smc
• Allele Name: spondylo-metaphyseal chondrodysplasia
• Allele ID: MGI:1857047
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	smc/smc	Not Specified	MGI:4412038

Genotype
MGI:4412038

hm1

• Allelic Composition: smc/smc
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body size ( J:13829 )

• slightly dwarfed

limbs/digits/tail

abnormal limb morphology ( J:13829 )

• bowed long bones

abnormal digit morphology ( J:13829 )

• toes of hind feet may be flexed laterally

short limbs ( J:13829 )

abnormal tail morphology ( J:13829 )

short tail ( J:13829 )

kinked tail ( J:13829 )

thick tail ( J:13829 )

reproductive system

female infertility ( J:13829 )

♀

skeleton

abnormal long bone epiphysis morphology ( J:13829 )

• enlarged epiphysis

thickened long bone epiphysis ( J:13829 )

abnormal long bone metaphysis morphology ( J:13829 )

• conformation abnormalities in the metaphyseal region

abnormal sternum morphology ( J:13829 )

• consists of atypical cartilage

abnormal costochondral joint morphology ( J:13829 )

• costo-chondral junctions are spread apart

short ribs ( J:13829 )

abnormal lumbar vertebrae morphology ( J:13829 )

• show excess terminal, atypical cartilage

abnormal sacral vertebrae morphology ( J:13829 )

• show excess terminal, atypical cartilage

abnormal chondrocyte morphology ( J:7484 )

• contain large amounts of lipid

abnormal epiphyseal plate morphology ( J:8100 )

• the growth plate is disrupted and secondary centers of ossification appear late

abnormal endochondral bone ossification ( J:13829 )

• lack of alignment and ordering of cells with provisional calcification before osteogenesis

• junction between bone and cartilage is excessively sharp and irregular