Phenotypes associated with this allele

• Allele Symbol: sps
• Allele Name: spontaneous seizure
• Allele ID: MGI:1857052
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	sps/sps	involves: C57BL/10Bg	MGI:4430562

Genotype
MGI:4430562

hm1

• Allelic Composition: sps/sps
• Genetic Background: involves: C57BL/10Bg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:32781 )

• due to death following seizures

postnatal lethality, incomplete penetrance ( J:32781 )

• usually follows development of seizures but some mice survive to 6 months of age

behavior/neurological

hyperresponsive to tactile stimuli ( J:32781 )

• noticed prior to seizure suseptibility

abnormal maternal nurturing ( J:12239 , J:32781 )

• mothers may ignore pups (J:12239)

♀ (J:32781)

convulsive seizures ( J:12239 , J:32781 )

• dams may die of spontaneous seizures (J:12239)

• spontaneous seizures occur in adolescent mice (J:32781)

growth/size/body

decreased body weight ( J:32781 )

nervous system

convulsive seizures ( J:12239 , J:32781 )

• dams may die of spontaneous seizures (J:12239)

• spontaneous seizures occur in adolescent mice (J:32781)

abnormal brain wave pattern ( J:6937 )

• behavioral arrest and convulsions have characteristic neocortical electroencephalographic (EEG) correlates

reproductive system

reduced fertility ( J:32781 )

• among survivors