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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tmiesr
spinner
MGI:1857053
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tmiesr/Tmiesr B6.B(CBA)-Tmiesr/J MGI:3698725
hm2
 		Tmiesr/Tmiesr C57BL/How-Tmiesr MGI:3832352
cx3
 		Tmiesr/cir involves: C57BL/6J * C57BL/How * ICR MGI:3832331


Genotype
MGI:3698725
hm1
Allelic
Composition		 Tmiesr/Tmiesr
Genetic
Background		 B6.B(CBA)-Tmiesr/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmiesr mutation (1 available); any Tmie mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal behavior ( J:144656 )
• in an open-field test, mice remain in the center longer than wild-type mice
abnormal reflex ( J:116914 )
• abnormal drop reflex; mice do not demonstrate expected dorsoflexion and spread out the front paws when quickly lowered from ~20 cm above a table surface, while controls do exhibit this behavior
impaired balance ( J:144656 )
• mice exhibit impaired balance on a stationary rod compared to wild-type mice
impaired swimming ( J:116914 )
• mice exhibit poor swimming ability; mice can not maneuver in the water and can not remain at the surface
circling ( J:116914 , J:144656 )
• mice exhibit circling with a decreased latency to start circling compared to in cir homozygotes (J:144656)

hearing/vestibular/ear
absent linear vestibular evoked potential ( J:116914 )
• VESPs are absent at the maximum stimulus intensity used




Genotype
MGI:3832352
hm2
Allelic
Composition		 Tmiesr/Tmiesr
Genetic
Background		 C57BL/How-Tmiesr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmiesr mutation (1 available); any Tmie mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
deafness ( J:13132 )
• from birth

behavior/neurological
abnormal reflex ( J:13132 )
• when suspended by their tails, mice twist and turn unlike wild-type mice
impaired swimming ( J:13132 )
• mice are unable to swim
head shaking ( J:13132 )
• first appearing at P7 and continuous
abnormal nursing ( J:13132 )
• female mice usually fail to nurse

growth/size/body
decreased body size ( J:13132 )
• slightly

nervous system




Genotype
MGI:3832331
cx3
Allelic
Composition		 Tmiesr/cir
Genetic
Background		 involves: C57BL/6J * C57BL/How * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
cir mutation (0 available); any cir mutation (0 available)
Tmiesr mutation (1 available); any Tmie mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal behavior ( J:144656 )
• in an open-field test, mice remain in the center longer than wild-type mice
impaired balance ( J:144656 )
• mice exhibit impaired balance on a stationary rod compared to wild-type mice
circling ( J:144656 )
• mice exhibit circling and an increased latency to start circling compared to wild-type mice or Tmiesr homozygotes




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory