Phenotypes associated with this allele

• Allele Symbol: srn
• Allele Name: siren
• Allele ID: MGI:1857054
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	srn/srn	involves: BUA/Hn * SM/J	MGI:4412006

Genotype
MGI:4412006

hm1

• Allelic Composition: srn/srn
• Genetic Background: involves: BUA/Hn * SM/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:64443 )

digestive/alimentary system

anal atresia ( J:64443 )

abnormal intestine morphology ( J:5150 )

• underdeveloped or blind

embryo

sirenomelia ( J:64443 )

• apodal, monopodal or dipodal

• more males than females are affected

limbs/digits/tail

sirenomelia ( J:64443 )

• apodal, monopodal or dipodal

• more males than females are affected

abnormal femur morphology ( J:64443 )

• femurs are usually medially fused because the ischium is missing or vestigial

absent hindlimb ( J:64443 )

• some affected mice have no hindlimbs although most show degrees of sirenomelia

abnormal tail morphology ( J:5150 )

• some mice have twisted, kinked, or otherwise abnormal tails

renal/urinary system

absent kidney ( J:64443 )

• occasionally both kidneys are missing

single kidney ( J:64443 )

• usually one kidney is missing

absent urinary bladder ( J:64443 )

skeleton

micrognathia ( J:5150 )

abnormal femur morphology ( J:64443 )

• femurs are usually medially fused because the ischium is missing or vestigial

abnormal ischium morphology ( J:64443 )

• ischium is missing or vestigial

ischium hypoplasia ( J:64443 )

craniofacial

micrognathia ( J:5150 )

decreased mouth size ( J:5150 )

• many mice of this genotype also have a small mouth

endocrine/exocrine glands

abnormal adrenal gland morphology ( J:5150 )

absent adrenal gland ( J:5150 )

• in some but not all of this genotype

growth/size/body

decreased mouth size ( J:5150 )

• many mice of this genotype also have a small mouth