Analysis Tools
craniofacial
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• skull length is 92% of normal
|
domed cranium
(
J:5109
)
|
• domed-shaped head is seen at 4-5 days of age
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growth/size/body
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• mutants are shorter and stockier
|
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• body length is reduced to 89% of normal
|
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• organ weights at 29-32 days of age 77-92% of normal, except the lungs and kidneys which are comparable in size to controls
|
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• growth is slightly retarded during the first 4 weeks and adults reach a weight within 3-6 gm of normal siblings
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limbs/digits/tail
short limbs
(
J:5109
)
|
• limbs are slightly shortened
|
short tail
(
J:5109
)
|
• tail length is reduced to 86% of normal
|
thick tail
(
J:5109
)
reproductive system
small testis
(
J:5109
)
 |
• testes weight at 29-32 days of age is 57% of normal
|
|
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• testes that produce no sperm were found in some mutants
|
|
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• most males do not breed
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skeleton
|
• proliferating cartilage cell columns are shorter
|
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• thinner epiphyseal plate
|
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• limb bone lengths are 85 to 90% of normal
|
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• axial skeleton is slightly shortened
|
|
• skull length is 92% of normal
|
domed cranium
(
J:5109
)
|
• domed-shaped head is seen at 4-5 days of age
|
|
• primary trabeculae are shorter, less numerous, and not aligned as well as in controls
|
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• chondrogenesis stops earlier than in normal mice
(J:5669)
|
endocrine/exocrine glands
small testis
(
J:5109
)
|
|
• testes weight at 29-32 days of age is 57% of normal
|
