growth/size/body
limbs/digits/tail
short humerus
(
J:11215
)
short ulna
(
J:11215
)
short femur
(
J:11215
)
short fibula
(
J:11215
)
short tibia
(
J:11215
)
short limbs
(
J:11215
)
short tail
(
J:11215
)
• tail has normal taper but is short and thick
|
skeleton
• affected mice can be distingished from normal siblings by 7 days of age
• abnormal skeletal development gives older mice a "dumpy" appearance but does not influence weight
|
short humerus
(
J:11215
)
short ulna
(
J:11215
)
short femur
(
J:11215
)
short fibula
(
J:11215
)
short tibia
(
J:11215
)
• some bone elements are shortened
|
• width of elements are reduced to 39% and 58% of normal for females and males respectively
• partial or complete failure of ischium and pubic bone to fuse
• bones are significantly thinner compared with normal siblings
|