Phenotypes associated with this allele

• Allele Symbol: tm
• Allele Name: tremulous
• Allele ID: MGI:1857075
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	tm/tm	Not Specified	MGI:2656274

Genotype
MGI:2656274

hm1

• Allelic Composition: tm/tm
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

tremors ( J:13085 )

• affected homozygotes exhibit tremors with no symptoms of convulsions

reproductive system

infertility ( J:13085 )

• affected homozygotes are sterile

homeostasis/metabolism

abnormal circulating protein level ( J:315 )

• at 5-7 months of age, affected homozygotes display significantly decreased serum globulin levels relative to normal siblings

• most of the decrease in the globulin level is due to a sharp decrease in the alpha fraction

increased circulating serum albumin level ( J:315 )

• at 5-7 months of age, affected homozygotes display significantly higher serum albumin levels than normal siblings

abnormal mineral level ( J:13085 )

• at 3 months of age, affected homozygotes display a higher concentration of creatine phosphate in the supernatant fraction of calcium-precipitated trichloracetic acid extracts of brain tissue relative to normal siblings

nervous system

abnormal nervous system physiology ( J:13085 )

• at 3 months of age, affected homozygotes display a higher concentration of creatine phosphate and ribose in the supernatant fraction of calcium-precipitated trichloracetic acid extracts of brain tissue relative to normal siblings

• authors interpret the increase of creatine phosphates as an indication of lowered brain activity; however, the increase of ribose levels in the calcium soluble fraction remains unclear