behavior/neurological
• after exertion, mice crouch in a corner of the cage and start trembling
• tremors were reduced by high doses of orphenadrine and hyoscine, but not alpha-methyldopa, atropine, barbituates, or nethalide
|
abnormal gait
(
J:5169
)
• lurching gait in which the hindlegs are lifted too high off the ground
|
growth/size/body
• lighter in weight than wild-type littermates throughout life
|
nervous system
N |
• normal brain morphology
• normal levels of brain amines and acetylcholine
|