Analysis Tools
mortality/aging
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• start to die around 18 weeks of age with most lost before 30 weeks of age
|
cellular
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• disorganized proliferation of chondrocytes in the protruded vertebral disks
|
skeleton
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• calcification of the Achilles tendon
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• changes are more pronounced and occur earlier in the superior spine than in the inferior spine
(J:19124)
• at 8 weeks of age, rigidity of the vertebral column
(J:37369)
|
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• proliferation of cartilaginous tissues followed by endochondral ossification occurs around the site of tendon attachment and the around the osseous membrane
(J:19124)
• at 10 weeks, proliferation of small fibroblast-like cells is seen at the site of ligament attachment and the posterior corner of the endplate
(J:43357)
|
osteoporosis
(
J:37369
)
|
• moderate
|
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• at 6 - 8 weeks , degeneration and necrosis of the chondrocytes with surrounding tidemarks of calcification are seen in the articular cartilage
|
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• treatment with streptozotocin increased membranous and enchondral ossification of the posterior longitudinal ligament of the cervical spine, esp. in the area of the ligamentous enthesis
• treatment with streptozotocin also increased the number of alkaline phosphatase positive osteoblast-like mesenchymal cells esp. around the enthesis
|
|
• at 3 - 4 weeks, papillary proliferation of synovial cells protrude into the articular space
(J:19124)
• at 6 - 8 weeks, cystic dilation of the articular sac, proliferation of synovial cells replacing articular cartilage, and some thicker collagen fibers with a longer periodicity are seen
(J:19124)
• at 8 - 12 weeks, fibrosis of the synovial tissue is seen, proliferation is not as obvious, and the articular sac is fibrous and thickened with calcification and proliferation of the cartilaginous tissue
(J:19124)
• around the site of tendon attachment osteophytes develop and after 20 weeks of age these may bridge the joint
(J:19124)
• at 8 weeks of age, stiffness of limb joints
(J:37369)
|
|
• initially at 4 weeks of age, an amorphous calcifying lesion is detected protruding from the cartilaginous endplates into the fibrocartilage in the superior and inferior spine
(J:19124)
• this lesion increases in size with age and degenerating or necrotic chondrocytes are seen around the lesion
(J:19124)
• abnormal disks protrude into the spinal canaliculi or surrounding soft tissue and are associated with thickening of the osseous membranes and bone formation outside the degenerated calcified fibrous cartilage
(J:19124)
• degeneration and destruction of the cartilage matrix with lateral protrusion
(J:37369)
• disorganized proliferation of chondrocytes and irregular calcification in the protruded vertebral disks
(J:37369)
• progressive dorsal and posterior protrusion of amorphous cartilaginous tissue from the posterior part of the intervertebral disk
(J:43357)
• osteoblast-like cells are detected in the posterior intervertebral disks and the membrane surrounding the amorphous protruding tissue is progressively ossified
(J:43357)
|
|
• calcified deposits can connect adjacent vertebral bodies similar to spur formation in osteoarthritis
• proliferation of fibrous tissue of the periosteum in areas over protruding intervertebral disks
• deposition of calcium in the intervertebral spaces especially at the edges of the vertebral bodies
|
|
• at 4 weeks of age calcium deposits begin to accumulate
(J:19124)
• at 6 - 8 weeks, calcium deposits are seen in the articular space and synovial tissue by 20 weeks of age the peripheral articular cartilage is replaced by bony tissue
(J:19124)
• by 20 weeks of age the peripheral articular cartilage is replaced by bony tissue
(J:19124)
• no pronounced deposition of calcium is seen in the kidneys
(J:19124)
• in limb joints
(J:37369)
|
|
• fibrous thickening of the ligaments around protruding intervertebral disks
|
|
• hypertrophy of the posterior longitudinal ligament in the cervical spine at 8 weeks of age
• at 10 weeks, proliferation of small fibroblast-like cells is seen at the site of ligament attachment in the spine
• osteoblast-like cells are detected in the posterior longitudinal ligament
• treatment with streptozotocin increases the area of ossification of the posterior longitudinal ligament
|
|
• disorganized proliferation of chondrocytes in the protruded vertebral disks
|
|
• erosion and destruction of limb joint articular cartilage with synovial cell proliferation but only occasional inflammation
(J:37369)
• subchondral bone absorption beneath the joint surface
(J:37369)
|
|
• deposition of calcium in the intervertebral spaces especially at the edges of the vertebral bodies
(J:37369)
• irregular calcium deposits in areas over protruding intervertebral disks
(J:37369)
• ossification of the membrane surrounding the abnormal amorphous tissue of the ligament enthesis
(J:43357)
|
growth/size/body
|
• streptozotocin-treated mice do not show any increase in body weight compared to to untreated mice unlike in wild-type mice
|
|
• at 8 weeks of age, cease to gain weight
|
behavior/neurological
|
• impaired grasping ability at 3 - 4 weeks of age
|
abnormal gait
(
J:37369
)
|
• by 8 weeks of age mice appear to walk on tiptoes
|
cardiovascular system
|
• calcification of the aorta
|
homeostasis/metabolism
| N |
• serum calcium and phosphorus levels are similar to wild-type
|
calcinosis
(
J:37369
)
|
• calcification of the hair follicles of the vibrissae, aorta, Achilles tendon, and limb joints
|
|
• serum alkaline phosphatase activity is increased at all ages tested and increases rather than decreases with age
|
immune system
|
• erosion and destruction of limb joint articular cartilage with synovial cell proliferation but only occasional inflammation
(J:37369)
• subchondral bone absorption beneath the joint surface
(J:37369)
|
muscle
|
• calcification of the Achilles tendon
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| ossification of the posterior longitudinal ligament of spine | DOID:0060887 |
OMIM:602475 |
J:43357 , J:48527 | |
| osteoarthritis | DOID:8398 | J:19124 , J:37369 | ||
| spondyloarthropathy | DOID:1123 | J:37369 | ||
