Phenotypes associated with this allele

• Allele Symbol: uns
• Allele Name: unsteady
• Allele ID: MGI:1857082
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	uns/uns	involves: C57BL/6J * CD-1	MGI:4365998

Genotype
MGI:4365998

hm1

• Allelic Composition: uns/uns
• Genetic Background: involves: C57BL/6J * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:14139 )

• affected mice live no longer than 6 months of age

behavior/neurological

ataxia ( J:14139 )

• evident by 3 weeks of age and progressive

abnormal posture ( J:14139 )

hunched posture ( J:14139 )

• by 3 months of age

abnormal gait ( J:14139 )

• movement becomes wobbly at rest and in motion

growth/size/body

decreased body size ( J:14139 )

• affected mice are smaller than littermates throughout life

muscle

skeletal muscle atrophy ( J:14139 )

• by 3 months of age hind limb muscles become atrophic

abnormal muscle contractility ( J:14139 )

abnormal muscle electrophysiology ( J:14139 )

• electrocorticographic recordings of affected mice aged 2 months or more reveal high-amplitude spike-and-wave complexes at approximately 30 sec intervals

nervous system

axon degeneration ( J:14139 )

• prominent in the deep cerebellar and lateral vestibular nuclei

reproductive system

female infertility ( J:14139 )

♀

male infertility ( J:14139 )

♂