All Phenotypes Gpr161<vl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gpr161^vl
vacuolated lens
MGI:1857087

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gpr161^vl/Gpr161^vl	C3Fe;C3Sn-Gpr161^vl/J	MGI:2174803
hm2	Gpr161^vl/Gpr161^vl	involves: C3H/HeSnJ * C57BL/6J	MGI:3775635
hm3	Gpr161^vl/Gpr161^vl	involves: C3H/HeSnJ * CAST/Ei	MGI:3775636
cx4	Gpr161^vl/Gpr161^vl Modvl1^C3H/HeSnJ/Modvl1^C3H/HeSnJ	involves: C3H/HeSnJ * C57BL/6J	MGI:3793319
cx5	Gpr161^vl/Gpr161^vl Modvl1^C3H/HeSnJ/Modvl1^C57BL/6J	involves: C3H/HeSnJ * C57BL/6J	MGI:3793320
cx6	Gpr161^vl/Gpr161^vl Modvl2^C3H/HeSnJ/Modvl2^C3H/HeSnJ	involves: C3H/HeSnJ * CAST/EiJ	MGI:3793323
cx7	Gpr161^vl/Gpr161^vl Modvl2^C3H/HeSnJ/Modvl2^CAST/EiJ	involves: C3H/HeSnJ * CAST/EiJ	MGI:3793324
cx8	Gpr161^vl/Gpr161^vl Modvl3^MOLF/EiJ/Modvl3^MOLF/EiJ	involves: C3H/HeSnJ * MOLF/EiJ	MGI:3793325
cx9	Gpr161^vl/Gpr161^vl Modvl3^C3H/HeSnJ/Modvl3^MOLF/EiJ	involves: C3H/HeSnJ * MOLF/EiJ	MGI:3793326

Allelic Composition	Gpr161^vl/Gpr161^vl
Genetic Background	C3Fe;C3Sn-Gpr161^vl/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr161^vl mutation (2 available); any Gpr161 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

lens vacuoles ( J:13464 )

• histologically, the lens shows small vacuoles at birth

cataract ( J:13464 )

• homozygotes have opaque white lenses

nervous system

spina bifida ( J:13464 )

• homozygotes may have caudal spina bifida

• spina bifida is present in all homozygous embryos at 11 to 12 days of gestation, but is visible in only one-third to one-half of them at birth; if the defect is not too severe, the lesion heals and the mice survive

pigmentation

belly spot ( J:13464 )

• although the lens defect is the most consistent landmark, occasionally homozygotes have only a white belly spot

hematopoietic system

hematopoietic system phenotype ( J:29151 )

N	• no aberrant bleeding time after tail vein nick

embryo

abnormal neural fold formation ( J:2004 )

• the caudal neural folds in vl/vl homozygotes display larger dorsolateral and ventral angles that normal at the 22--28 somite embryonic stage

• at the 30-35 somite stage, the ventral angles remain larger than normal, but the dorsolateral angles are smaller than normal, indicating a medial collapse of the dorsal ends of the neural folds

• a defect in microfilaments may underly this abnormal bending of the neuroepithelium

spina bifida ( J:13464 )

• homozygotes may have caudal spina bifida

integument

belly spot ( J:13464 )

• although the lens defect is the most consistent landmark, occasionally homozygotes have only a white belly spot

Allelic Composition	Gpr161^vl/Gpr161^vl
Genetic Background	involves: C3H/HeSnJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr161^vl mutation (2 available); any Gpr161 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

hindlimb paralysis ( J:131929 )

• Background Sensitivity: seen in about 50% of adults on a mixed C3H/HeSnJ and C57BL/6J but never in adults on a pure C3H/HeSnJ background

nervous system

spina bifida ( J:131929 )

• Background Sensitivity: seen in about 50% of adults on a mixed C3H/HeSnJ and C57BL/6J but never in adults on a pure C3H/HeSnJ or a mixed C3H/HeSnJ and MOLF/Ei background

embryo

spina bifida ( J:131929 )

• Background Sensitivity: seen in about 50% of adults on a mixed C3H/HeSnJ and C57BL/6J but never in adults on a pure C3H/HeSnJ or a mixed C3H/HeSnJ and MOLF/Ei background

Allelic Composition	Gpr161^vl/Gpr161^vl
Genetic Background	involves: C3H/HeSnJ * CAST/Ei

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr161^vl mutation (2 available); any Gpr161 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

hindlimb paralysis ( J:131929 )

• Background Sensitivity: seen in about 50% of adults on a mixed C3H/HeSnJ and C57BL/6J but never in adults on a pure C3H/HeSnJ background

nervous system

spina bifida ( J:131929 )

• Background Sensitivity: seen in about 50% of adults on a mixed C3H/HeSnJ and C57BL/6J but never in adults on a pure C3H/HeSnJ or a mixed C3H/HeSnJ and MOLF/Ei background

embryo

spina bifida ( J:131929 )

• Background Sensitivity: seen in about 50% of adults on a mixed C3H/HeSnJ and C57BL/6J but never in adults on a pure C3H/HeSnJ or a mixed C3H/HeSnJ and MOLF/Ei background

Allelic Composition	Gpr161^vl/Gpr161^vl Modvl1^C3H/HeSnJ/Modvl1^C3H/HeSnJ
Genetic Background	involves: C3H/HeSnJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr161^vl mutation (2 available); any Gpr161 mutation (30 available)
Modvl1^C3H/HeSnJ mutation (0 available); any Modvl1 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

spina bifida ( J:131929 )

• increased spina bifida incidence

embryo

spina bifida ( J:131929 )

• increased spina bifida incidence

Allelic Composition	Gpr161^vl/Gpr161^vl Modvl1^C3H/HeSnJ/Modvl1^C57BL/6J
Genetic Background	involves: C3H/HeSnJ * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

spina bifida ( J:131929 )

• increased spina bifida incidence

embryo

spina bifida ( J:131929 )

• increased spina bifida incidence

Allelic Composition	Gpr161^vl/Gpr161^vl Modvl2^C3H/HeSnJ/Modvl2^C3H/HeSnJ
Genetic Background	involves: C3H/HeSnJ * CAST/EiJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr161^vl mutation (2 available); any Gpr161 mutation (30 available)
Modvl2^C3H/HeSnJ mutation (0 available); any Modvl2 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

spina bifida ( J:131929 )

• increased spina bifida incidence

embryo

spina bifida ( J:131929 )

• increased spina bifida incidence

Allelic Composition	Gpr161^vl/Gpr161^vl Modvl2^C3H/HeSnJ/Modvl2^CAST/EiJ
Genetic Background	involves: C3H/HeSnJ * CAST/EiJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

spina bifida ( J:131929 )

• increased spina bifida incidence

embryo

spina bifida ( J:131929 )

• increased spina bifida incidence

Allelic Composition	Gpr161^vl/Gpr161^vl Modvl3^MOLF/EiJ/Modvl3^MOLF/EiJ
Genetic Background	involves: C3H/HeSnJ * MOLF/EiJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr161^vl mutation (2 available); any Gpr161 mutation (30 available)
Modvl3^MOLF/EiJ mutation (0 available); any Modvl3 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

cataract ( J:131929 )

• increased incidence of cataracts

Allelic Composition	Gpr161^vl/Gpr161^vl Modvl3^C3H/HeSnJ/Modvl3^MOLF/EiJ
Genetic Background	involves: C3H/HeSnJ * MOLF/EiJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr161^vl mutation (2 available); any Gpr161 mutation (30 available)
Modvl3^C3H/HeSnJ mutation (0 available); any Modvl3 mutation (0 available)
Modvl3^MOLF/EiJ mutation (0 available); any Modvl3 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

cataract ( J:131929 )

• increased incidence of cataracts

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