Phenotypes associated with this allele

• Allele Symbol: Mip^Cat-Fr
• Allele Name: dominant cataract Fraser
• Allele ID: MGI:1857104
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mip^Cat-Fr/Mip^Cat-Fr	involves: A/J	MGI:2175110

Genotype
MGI:2175110

hm1

• Allelic Composition: Mip^Cat-Fr/Mip^Cat-Fr
• Genetic Background: involves: A/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal lens fiber morphology ( J:5104 , J:5114 , J:30791 )

• at 14 days of gestation, the centrally located nuclei of the lens fibers are seen to be abnormally small and dark with indistinct nucleoli (J:5104)

• nuclear degeneration is followed by swelling and vacuolization of the lens fibers (J:5104)

• the main lens fiber mass degenerates (J:5114)

• the epithelial cells form multiple layers of atypical cells (J:5114)

• by electron microscopy, changes can be seen in the nuclear envelope of the primary lens fibers in 12-day embryos (J:30791)

cataract ( J:5114 )

• lens opacities are visible when the eyes first open at 14 days

small lens ( J:5114 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract 15 multiple types		DOID:0110251	OMIM:615274	J:31574