All Phenotypes t<w18> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

t^w18
t, wild 18
MGI:1857112

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	t^w18/t^w18	Not Specified	MGI:5013810
ht2	t^hr4/t^w18	Not Specified	MGI:5465158
cx3	Nme3^tm1Bgh/Nme3⁺ t^w18/t⁺	involves: 129S1/Sv	MGI:5319399
cx4	t^w18/t⁺ Tiam2^tm1Bgh/Tiam2^tm1Bgh	involves: 129S/SvEv * 129S1/Sv	MGI:6360722
cx5	t^w18/t⁺ Tiam2^tm1Bgh/Tiam2⁺ Tg(Ace-Tiam2)C11S1Bgh/0	involves: 129S/SvEv * 129S1/Sv	MGI:6360725

Allelic Composition	t^w18/t^w18
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
t^w18 mutation (0 available); any t mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:23646 )

• between E9 and E10

• embryos are dead or show signs of deterioration and impending death

embryo

abnormal primitive streak formation ( J:23646 )

• at E7 histological analysis reveals a thickening of the egg cylinder in the region of the primitive streak

• at E8 distinctive overgrowth of the primitive streak is seen, with a median bulge projecting dorsally into the amniotic cavity

Allelic Composition	t^hr4/t^w18
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
t^hr4 mutation (0 available); any t mutation (19 available)
t^w18 mutation (0 available); any t mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:169366 )

N	• mice are viable

Allelic Composition	Nme3^tm1Bgh/Nme3⁺ t^w18/t⁺
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nme3^tm1Bgh mutation (0 available); any Nme3 mutation (10 available)
t^w18 mutation (0 available); any t mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

transmission ratio distortion ( J:183481 )

• mice exhibit increased transmission of the t-haplotype compared with wild-type mice

Allelic Composition	t^w18/t⁺ Tiam2^tm1Bgh/Tiam2^tm1Bgh
Genetic Background	involves: 129S/SvEv * 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tiam2^tm1Bgh mutation (0 available); any Tiam2 mutation (105 available)
t^w18 mutation (0 available); any t mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

transmission ratio distortion ( J:273736 )

• whether alleles are in cis or trans, mice exhibit reduced transmission of t^w18 compared with wild-type mice

Allelic Composition	t^w18/t⁺ Tiam2^tm1Bgh/Tiam2⁺ Tg(Ace-Tiam2)C11S1Bgh/0
Genetic Background	involves: 129S/SvEv * 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ace-Tiam2)C11S1Bgh mutation (0 available)
Tiam2^tm1Bgh mutation (0 available); any Tiam2 mutation (105 available)
t^w18 mutation (0 available); any t mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

transmission ratio distortion ( J:273736 )

• mice exhibit increased transmission of t^w18 compared with wild-type mice

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