Phenotypes associated with this allele

• Allele Symbol: Ace^tm2Unc
• Allele Name: targeted mutation 2, University of North Carolina
• Allele ID: MGI:1857116
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ace^tm2Unc/Ace^tm2Unc	involves: 129P2/OlaHsd * C57BL/6J	MGI:3618211

Genotype
MGI:3618211

hm1

• Allelic Composition: Ace^tm2Unc/Ace^tm2Unc
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:46177 )

• at weaning, homozygotes are obtained at a significantly reduced Mendelian frequency

renal/urinary system

abnormal kidney vasculature morphology ( J:46177 )

• 2 out of 2 mutant kidneys exhibit vascular hyperplasia

kidney atrophy ( J:46177 )

• 2 out of 2 mutant kidneys show cortical atrophy

reproductive system

reproductive system phenotype ( J:46177 )

N • unlike Ace^tm1Unc homozygotes lacking both isozymes which display reduced male fertility, male homozygotes that lack the somatic isoform but retain the testicular isoform display normal fertility with no sperm defects in the zona pellucida binding assay

cardiovascular system

abnormal kidney vasculature morphology ( J:46177 )

• 2 out of 2 mutant kidneys exhibit vascular hyperplasia