Phenotypes associated with this allele

• Allele Symbol: Adrb1^tm1Bkk
• Allele Name: targeted mutation 1, Brian K Kobilka
• Allele ID: MGI:1857120
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adrb1^tm1Bkk/Adrb1^tm1Bkk	either: (involves: 129/Sv) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2)	MGI:2388096
cx2	Adrb1^tm1Bkk/Adrb1^tm1Bkk Adrb2^tm1Bkk/Adrb2^tm1Bkk	involves: 129S1/Sv * 129X1/SvJ	MGI:3579029
cx3	Adrb1^tm1Bkk/Adrb1^tm1Bkk Adrb2^tm1Bkk/Adrb2^tm1Bkk	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N	MGI:2388098
cx4	Adrb1^tm1Bkk/Adrb1^tm1Bkk Adrb2^tm1Bkk/Adrb2^tm1Bkk Adrb3^tm1Lowl/Adrb3^tm1Lowl	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N	MGI:2388265

Genotype
MGI:2388096

hm1

• Allelic Composition: Adrb1^tm1Bkk/Adrb1^tm1Bkk
• Genetic Background: either: (involves: 129/Sv) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:34659 )

• Background Sensitivity: 70% dead by E18.5 on mixed 129/Sv x C57BL/6J x DBA/2 background, 90% dead by E18.5 on 129/Sv background

cardiovascular system

cardiovascular system phenotype ( J:34659 )

N • in mice that survived to adulthood, gross morphology and myocyte appearance were normal, normal heart rate and blood pressure under basal conditions

abnormal cardiovascular system physiology ( J:34659 )

• mice challened with the nonspecific beta-adrenergic receptor agonist isoproterenol do not exhibit the increase in heart rate or cardiac contractility normally seen with this drug

homeostasis/metabolism

abnormal physiological response to xenobiotic ( J:34659 )

• mice challened with the nonspecific beta-adrenergic receptor agonist isoproterenol do not exhibit the increase in heart rate or cardiac contractility normally seen with this drug

Genotype
MGI:3579029

cx2

• Allelic Composition: Adrb1^tm1Bkk/Adrb1^tm1Bkk; Adrb2^tm1Bkk/Adrb2^tm1Bkk
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

skeleton

skeleton phenotype ( J:97566 )

N • exhibit normal bone mass at 6 months of age

Genotype
MGI:2388098

cx3

• Allelic Composition: Adrb1^tm1Bkk/Adrb1^tm1Bkk; Adrb2^tm1Bkk/Adrb2^tm1Bkk
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

cardiovascular system

abnormal cardiovascular system physiology ( J:55553 )

• abnormal responses to pharmacological stimuli; attenuation of both the normal tachycardia and hypotensive responses to isoproterenol administration and bradycardia and monophasic hypertension in response to epinephrine administration

decreased cardiac muscle contractility ( J:55553 )

• reduced cardiac contractility in awake and in anesthetized mice

decreased heart rate ( J:55553 )

• decreased heart rate in response to exercise, but normal basal heart rate, normal basal mean arterial blood pressure and normal blood pressure changes in response to exercise

homeostasis/metabolism

decreased oxygen consumption ( J:55553 )

• reduced O₂ consumption during exercise and reduced CO₂ production during exercise, but normal total exercise capacity

abnormal response/metabolism to endogenous compounds ( J:55553 )

• abnormal responses to pharmacological stimuli; attenuation of the normal bradycardia and monophasic hypertension in response to epinephrine administration

abnormal physiological response to xenobiotic ( J:55553 )

• abnormal responses to pharmacological stimuli; attenuation of the normal tachycardia and hypotensive responses to isoproterenol administration

muscle

decreased cardiac muscle contractility ( J:55553 )

• reduced cardiac contractility in awake and in anesthetized mice

Genotype
MGI:2388265

cx4

• Allelic Composition: Adrb1^tm1Bkk/Adrb1^tm1Bkk; Adrb2^tm1Bkk/Adrb2^tm1Bkk; Adrb3^tm1Lowl/Adrb3^tm1Lowl
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

adipose tissue

increased total body fat amount ( J:79309 )

• obesity attributable to increased fat mass

abnormal brown adipose tissue morphology ( J:79309 )

• interscapular brown adipose tissue (BAT) enlarged and pale

• BAT contained large cells with unilocular triglyceride deposits

increased brown fat cell size ( J:79309 )

increased interscapular fat pad weight ( J:79309 )

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:79309 )

N • normal thyroid hormone levels

growth/size/body

increased body weight ( J:79309 )

obese ( J:79309 )

• on regular Chow diet, mildly obese by 20 weeks; increased obesity on high fat diet (58% of kcal from fat)

• normal food intake and normal physical activity on both normal and high fat diets were observed, however

homeostasis/metabolism

impaired adaptive thermogenesis ( J:79309 )

• normal body temperature under conventional housing conditions, but exposure to cold (22^oC) produced rapid decline in core body temperature

• failure of diet-induced thermogenesis

increased circulating leptin level ( J:79309 )

• increased leptin levels

decreased oxygen consumption ( J:79309 )

• reduced metabolic rate, measured by O₂ consumption

• isoproterenol exposure failed to increase O₂ consumption

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
obesity		DOID:9970	OMIM:601665	J:79309