Phenotypes associated with this allele

• Allele Symbol: Agt^tm1Unc
• Allele Name: targeted mutation 1, University of North Carolina
• Allele ID: MGI:1857121
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Agt^tm1Unc/Agt^tm1Unc	involves: 129P2/OlaHsd * C57BL/6J	MGI:3619128
ht2	Agt^tm1Unc/Agt^+	involves: 129P2/OlaHsd * C57BL/6J	MGI:3619121
ht3	Agt^tm1Unc/Agt^tm2Unc	involves: 129P2/OlaHsd * C57BL/6J	MGI:3619130

Genotype
MGI:3619128

hm1

• Allelic Composition: Agt^tm1Unc/Agt^tm1Unc
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:24156 )

• postnatal survival is severely compromised, however a few survive to adulthood

homeostasis/metabolism

decreased circulating angiotensinogen level ( J:24156 )

• have no detectable levels of angiotensinogen

cardiovascular system

abnormal kidney vasculature morphology ( J:24156 )

• kidney vessels exhibit thickened walls caused by increased numbers of cells, which appear disorganized

abnormal kidney interlobular artery morphology ( J:24156 )

• defects are most pronounced in interlobular arteries

decreased systemic arterial blood pressure ( J:24156 )

renal/urinary system

abnormal kidney vasculature morphology ( J:24156 )

• kidney vessels exhibit thickened walls caused by increased numbers of cells, which appear disorganized

abnormal kidney interlobular artery morphology ( J:24156 )

• defects are most pronounced in interlobular arteries

tubulointerstitial nephritis ( J:24156 )

• atrophied areas show interstitial infiltration of chronic inflammatory cells

renal interstitial fibrosis ( J:24156 )

• atrophied areas show interstitial fibrosis

kidney atrophy ( J:24156 )

• kidneys exhibit focal areas of severe atrophy

kidney cortex atrophy ( J:24156 )

• generalized cortical thinning with focal areas of severe atrophy

renal tubule atrophy ( J:24156 )

• atrophied areas show shrinkage and loss of tubules

immune system

tubulointerstitial nephritis ( J:24156 )

• atrophied areas show interstitial infiltration of chronic inflammatory cells

Genotype
MGI:3619121

ht2

• Allelic Composition: Agt^tm1Unc/Agt⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

homeostasis/metabolism

decreased circulating angiotensinogen level ( J:18272 , J:24156 )

• have 35% of the level of angiotensinogen seen in wild-type (J:18272)

increased circulating renin level ( J:24156 )

• renin levels are 250% of normal levels

cardiovascular system

increased renal plasma flow rate ( J:24156 )

decreased systemic arterial blood pressure ( J:24156 )

renal/urinary system

renal/urinary system phenotype ( J:24156 )

N • kidneys and glomerular filtration rate are normal

increased renal plasma flow rate ( J:24156 )

reproductive system

reproductive system phenotype ( J:24156 )

N • do not exhibit a defect in ovulatory capacity is response to superovulation

Genotype
MGI:3619130

ht3

• Allelic Composition: Agt^tm1Unc/Agt^tm2Unc
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

homeostasis/metabolism

decreased circulating angiotensinogen level ( J:24156 )

• steady-state plasma angiotensinogen levels are 55% of the normal wild-type level

cardiovascular system

cardiovascular system phenotype ( J:24156 )

N • blood pressure is normal

renal/urinary system

renal/urinary system phenotype ( J:24156 )

N • kidneys are normal