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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Agttm2Unc
targeted mutation 2, University of North Carolina
MGI:1857122
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Agttm2Unc/Agttm2Unc involves: 129P2/OlaHsd * C57BL/6J MGI:3619131
ht2
 		Agttm2Unc/Agt+ involves: 129P2/OlaHsd * C57BL/6J MGI:3619123
ht3
 		Agttm1Unc/Agttm2Unc involves: 129P2/OlaHsd * C57BL/6J MGI:3619130


Genotype
MGI:3619131
hm1
Allelic
Composition		 Agttm2Unc/Agttm2Unc
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agttm2Unc mutation (1 available); any Agt mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating angiotensinogen level ( J:24156 )
• have about 144.5% of the level of angiotensinogen seen in wild-type

cardiovascular system
increased systemic arterial blood pressure ( J:24156 )
• blood pressure is increased about 16 mmHg compared to wild-type

reproductive system
decreased superovulation rate ( J:69609 )
• exhibit a reduction of ovulatory capacity in response to superovulation, however exhibit normal numbers of follicles, serum estradiol levels and early embryonic development of zygotes

renal/urinary system
renal/urinary system phenotype ( J:24156 )
N
• kidneys are normal




Genotype
MGI:3619123
ht2
Allelic
Composition		 Agttm2Unc/Agt+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agttm2Unc mutation (1 available); any Agt mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating angiotensinogen level ( J:18272 , J:24156 )
• have about 124% of the level of angiotensinogen seen in wild-type (J:18272)

cardiovascular system
increased systemic arterial blood pressure ( J:24156 )
• blood pressure is increased about 8 mmHg compared to wild-type

reproductive system
decreased superovulation rate ( J:69609 )
• exhibit a reduction of ovulatory capacity in response to superovulation, however exhibit normal numbers of follicles, serum estradiol levels and early embryonic development of zygotes

renal/urinary system
renal/urinary system phenotype ( J:24156 )
N
• kidneys, renal plasma flow and glomerular filtration rate are normal




Genotype
MGI:3619130
ht3
Allelic
Composition		 Agttm1Unc/Agttm2Unc
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agttm1Unc mutation (2 available); any Agt mutation (35 available)
Agttm2Unc mutation (1 available); any Agt mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating angiotensinogen level ( J:24156 )
• steady-state plasma angiotensinogen levels are 55% of the normal wild-type level

cardiovascular system
cardiovascular system phenotype ( J:24156 )
N
• blood pressure is normal

renal/urinary system
renal/urinary system phenotype ( J:24156 )
N
• kidneys are normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory