All Phenotypes Amh<tm1Bhr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Amh^tm1Bhr
targeted mutation 1, Richard R Behringer
MGI:1857126

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Amh^tm1Bhr/Amh^tm1Bhr	either: (involves: 129P3/J * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)	MGI:2450393
hm2	Amh^tm1Bhr/Amh^tm1Bhr	involves: 129S7/SvEvBrd * C57BL/6	MGI:2653866
ht3	Amh^tm1Bhr/Amh⁺	involves: 129S7/SvEvBrd * C57BL/6	MGI:2450405
cx4	Amh^tm1Bhr/Amh^tm1Bhr Ar^Tfm/Y	either: (involves: 129P3/J * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)	MGI:2450394
cx5	Amh^tm1Bhr/Amh⁺ Amhr2^tm1Bhr/Amhr2^tm1Bhr	involves: 129S7/SvEvBrd * C57BL/6	MGI:3042189
cx6	Amh^tm1Bhr/Amh^tm1Bhr Amhr2^tm1Bhr/Amhr2^tm1Bhr	Not Specified	MGI:3042185

Allelic Composition	Amh^tm1Bhr/Amh^tm1Bhr
Genetic Background	either: (involves: 129P3/J * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amh^tm1Bhr mutation (2 available); any Amh mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased Leydig cell number ( J:21396 )

• focal hyperplasia in 27% of males 10 weeks or older

• in spite of the hyperplasia, the cells were functionally normal

• one neoplasm containing multiple foci of leydig cell hyperplasia was detected

reproductive system

reproductive system phenotype ( J:21396 )

N	• XX females were fertile and displayed normal uteri containing morphologically normal oviducts

increased Leydig cell number ( J:21396 )

• focal hyperplasia in 27% of males 10 weeks or older

• in spite of the hyperplasia, the cells were functionally normal

• one neoplasm containing multiple foci of leydig cell hyperplasia was detected

male pseudohermaphroditism ( J:21396 )

• XY male mice developed hypoplastic female structures derived from the Mullerian duct, namely a uterus, uncoiled oviducts, and a vagina

• uterine horns paralleled the vas deferens and joined to form cervix that opened into a vagina

• the physical association of the uterine horns with the vas deferens caused the horns to be pulled caudally

• XY males displayed normal sized testes that were fully descended and spermatogenesis was unimpaired

• proper differentiation of the Wolffian duct system

secondary sex reversal ( J:21396 )

reduced male fertility ( J:21396 )

• 13% of males were able to impregnate wild-type females

• infertility putatively due to a blockage of sperm movement resulting in a diversion from the normal pathway

Allelic Composition	Amh^tm1Bhr/Amh^tm1Bhr
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amh^tm1Bhr mutation (2 available); any Amh mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

decreased primordial ovarian follicle number ( J:58577 )

• reduced number of primordial follicles observed at 4 months, with further decrease at 13 months

increased secondary ovarian follicle number ( J:58577 )

• increased numbers of preantral follicles at 25 days and 4 months

increased tertiary ovarian follicle number ( J:58577 )

• increased numbers of small antral follicles at 25 days and 4 months

increased ovary weight ( J:58577 )

• while the ovaries were morphologically normal at 25 days and 13 months, the weight was 1.8 fold higher than wild-type at 4 months of age

growth/size/body

increased ovary weight ( J:58577 )

• while the ovaries were morphologically normal at 25 days and 13 months, the weight was 1.8 fold higher than wild-type at 4 months of age

homeostasis/metabolism

suppressed circulating follicle stimulating hormone level ( J:58577 )

• observed in females 4 months of age

reproductive system

decreased primordial ovarian follicle number ( J:58577 )

• reduced number of primordial follicles observed at 4 months, with further decrease at 13 months

increased secondary ovarian follicle number ( J:58577 )

• increased numbers of preantral follicles at 25 days and 4 months

increased tertiary ovarian follicle number ( J:58577 )

• increased numbers of small antral follicles at 25 days and 4 months

increased ovary weight ( J:58577 )

• while the ovaries were morphologically normal at 25 days and 13 months, the weight was 1.8 fold higher than wild-type at 4 months of age

Allelic Composition	Amh^tm1Bhr/Amh⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amh^tm1Bhr mutation (2 available); any Amh mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased ovary weight ( J:58577 )

• the ovarian weight was greater than that of wild-type mice and less than that of homozygous mutant mice

reproductive system

increased ovary weight ( J:58577 )

• the ovarian weight was greater than that of wild-type mice and less than that of homozygous mutant mice

growth/size/body

increased ovary weight ( J:58577 )

• the ovarian weight was greater than that of wild-type mice and less than that of homozygous mutant mice

Allelic Composition	Amh^tm1Bhr/Amh^tm1Bhr Ar^Tfm/Y
Genetic Background	either: (involves: 129P3/J * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amh^tm1Bhr mutation (2 available); any Amh mutation (24 available)
Ar^Tfm mutation (1 available); any Ar mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

arrest of spermatogenesis ( J:21396 )

abnormal male reproductive system morphology ( J:21396 )

cryptorchism ( J:21396 )

absent epididymis ( J:21396 )

absent vas deferens ( J:21396 )

• absence of vas deferens

abnormal secondary sex determination ( J:21396 )

male pseudohermaphroditism ( J:21396 )

• XY male mice developed undescended dysfunctional testes, uteri, coiled oviducts, and a vagina with an opening

secondary sex reversal ( J:21396 )

endocrine/exocrine glands

cryptorchism ( J:21396 )

Allelic Composition	Amh^tm1Bhr/Amh⁺ Amhr2^tm1Bhr/Amhr2^tm1Bhr
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amhr2^tm1Bhr mutation (0 available); any Amhr2 mutation (29 available)
Amh^tm1Bhr mutation (2 available); any Amh mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased testis tumor incidence ( J:36027 )

• unilateral stromal tumors observed in the testes of some mice at 6 to 7 months of age

reproductive system

increased testis tumor incidence ( J:36027 )

• unilateral stromal tumors observed in the testes of some mice at 6 to 7 months of age

male pseudohermaphroditism ( J:36027 )

secondary sex reversal ( J:36027 )

endocrine/exocrine glands

increased testis tumor incidence ( J:36027 )

• unilateral stromal tumors observed in the testes of some mice at 6 to 7 months of age

Allelic Composition	Amh^tm1Bhr/Amh^tm1Bhr Amhr2^tm1Bhr/Amhr2^tm1Bhr
Genetic Background	Not Specified

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:36027 )

N	• female mice developed normally and were fertile

male pseudohermaphroditism ( J:36027 )

• males developed Mullerian duct derivatives

• male mice had testes of normal size that were properly descended into the scrotal sac

• normal differentiation of male-specific Wolffian duct-derived tissue

secondary sex reversal ( J:36027 )

male infertility ( J:36027 )

• spermatogenesis was unimpaired, however males were infertile due to the presence of female reproductive organs that blocked sperm transfer

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