All Phenotypes Amh<tm1Bhr> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Amh^tm1Bhr
targeted mutation 1, Richard R Behringer
MGI:1857126

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Amh^tm1Bhr/Amh^tm1Bhr	either: (involves: 129P3/J * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)	MGI:2450393
hm2	Amh^tm1Bhr/Amh^tm1Bhr	involves: 129S7/SvEvBrd * C57BL/6	MGI:2653866
ht3	Amh^tm1Bhr/Amh⁺	involves: 129S7/SvEvBrd * C57BL/6	MGI:2450405
cx4	Amh^tm1Bhr/Amh^tm1Bhr Ar^Tfm/Y	either: (involves: 129P3/J * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)	MGI:2450394
cx5	Amh^tm1Bhr/Amh⁺ Amhr2^tm1Bhr/Amhr2^tm1Bhr	involves: 129S7/SvEvBrd * C57BL/6	MGI:3042189
cx6	Amh^tm1Bhr/Amh^tm1Bhr Amhr2^tm1Bhr/Amhr2^tm1Bhr	Not Specified	MGI:3042185

Allelic Composition	Amh^tm1Bhr/Amh^tm1Bhr
Genetic Background	either: (involves: 129P3/J * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amh^tm1Bhr mutation (2 available); any Amh mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased Leydig cell number ( J:21396 )

• focal hyperplasia in 27% of males 10 weeks or older

• in spite of the hyperplasia, the cells were functionally normal

• one neoplasm containing multiple foci of leydig cell hyperplasia was detected

reproductive system

reproductive system phenotype ( J:21396 )

N	• XX females were fertile and displayed normal uteri containing morphologically normal oviducts

increased Leydig cell number ( J:21396 )

• focal hyperplasia in 27% of males 10 weeks or older

• in spite of the hyperplasia, the cells were functionally normal

• one neoplasm containing multiple foci of leydig cell hyperplasia was detected

male pseudohermaphroditism ( J:21396 )

• XY male mice developed hypoplastic female structures derived from the Mullerian duct, namely a uterus, uncoiled oviducts, and a vagina

• uterine horns paralleled the vas deferens and joined to form cervix that opened into a vagina

• the physical association of the uterine horns with the vas deferens caused the horns to be pulled caudally

• XY males displayed normal sized testes that were fully descended and spermatogenesis was unimpaired

• proper differentiation of the Wolffian duct system

secondary sex reversal ( J:21396 )

reduced male fertility ( J:21396 )

• 13% of males were able to impregnate wild-type females

• infertility putatively due to a blockage of sperm movement resulting in a diversion from the normal pathway

Allelic Composition	Amh^tm1Bhr/Amh^tm1Bhr
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amh^tm1Bhr mutation (2 available); any Amh mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

decreased primordial ovarian follicle number ( J:58577 )

• reduced number of primordial follicles observed at 4 months, with further decrease at 13 months

increased secondary ovarian follicle number ( J:58577 )

• increased numbers of preantral follicles at 25 days and 4 months

increased tertiary ovarian follicle number ( J:58577 )

• increased numbers of small antral follicles at 25 days and 4 months

increased ovary weight ( J:58577 )

• while the ovaries were morphologically normal at 25 days and 13 months, the weight was 1.8 fold higher than wild-type at 4 months of age

growth/size/body

increased ovary weight ( J:58577 )

• while the ovaries were morphologically normal at 25 days and 13 months, the weight was 1.8 fold higher than wild-type at 4 months of age

homeostasis/metabolism

suppressed circulating follicle stimulating hormone level ( J:58577 )

• observed in females 4 months of age

reproductive system

decreased primordial ovarian follicle number ( J:58577 )

• reduced number of primordial follicles observed at 4 months, with further decrease at 13 months

increased secondary ovarian follicle number ( J:58577 )

• increased numbers of preantral follicles at 25 days and 4 months

increased tertiary ovarian follicle number ( J:58577 )

• increased numbers of small antral follicles at 25 days and 4 months

increased ovary weight ( J:58577 )

• while the ovaries were morphologically normal at 25 days and 13 months, the weight was 1.8 fold higher than wild-type at 4 months of age

Allelic Composition	Amh^tm1Bhr/Amh⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amh^tm1Bhr mutation (2 available); any Amh mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased ovary weight ( J:58577 )

• the ovarian weight was greater than that of wild-type mice and less than that of homozygous mutant mice

reproductive system

increased ovary weight ( J:58577 )

• the ovarian weight was greater than that of wild-type mice and less than that of homozygous mutant mice

growth/size/body

increased ovary weight ( J:58577 )

• the ovarian weight was greater than that of wild-type mice and less than that of homozygous mutant mice

Allelic Composition	Amh^tm1Bhr/Amh^tm1Bhr Ar^Tfm/Y
Genetic Background	either: (involves: 129P3/J * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amh^tm1Bhr mutation (2 available); any Amh mutation (24 available)
Ar^Tfm mutation (1 available); any Ar mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

arrest of spermatogenesis ( J:21396 )

abnormal male reproductive system morphology ( J:21396 )

cryptorchism ( J:21396 )

absent epididymis ( J:21396 )

absent vas deferens ( J:21396 )

• absence of vas deferens

abnormal secondary sex determination ( J:21396 )

male pseudohermaphroditism ( J:21396 )

• XY male mice developed undescended dysfunctional testes, uteri, coiled oviducts, and a vagina with an opening

secondary sex reversal ( J:21396 )

endocrine/exocrine glands

cryptorchism ( J:21396 )

Allelic Composition	Amh^tm1Bhr/Amh⁺ Amhr2^tm1Bhr/Amhr2^tm1Bhr
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amhr2^tm1Bhr mutation (0 available); any Amhr2 mutation (29 available)
Amh^tm1Bhr mutation (2 available); any Amh mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased testis tumor incidence ( J:36027 )

• unilateral stromal tumors observed in the testes of some mice at 6 to 7 months of age

reproductive system

increased testis tumor incidence ( J:36027 )

• unilateral stromal tumors observed in the testes of some mice at 6 to 7 months of age

male pseudohermaphroditism ( J:36027 )

secondary sex reversal ( J:36027 )

endocrine/exocrine glands

increased testis tumor incidence ( J:36027 )

• unilateral stromal tumors observed in the testes of some mice at 6 to 7 months of age

Allelic Composition	Amh^tm1Bhr/Amh^tm1Bhr Amhr2^tm1Bhr/Amhr2^tm1Bhr
Genetic Background	Not Specified

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:36027 )

N	• female mice developed normally and were fertile

male pseudohermaphroditism ( J:36027 )

• males developed Mullerian duct derivatives

• male mice had testes of normal size that were properly descended into the scrotal sac

• normal differentiation of male-specific Wolffian duct-derived tissue

secondary sex reversal ( J:36027 )

male infertility ( J:36027 )

• spermatogenesis was unimpaired, however males were infertile due to the presence of female reproductive organs that blocked sperm transfer

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24