Analysis Tools
growth/size/body
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• male mice on a high fat diet have significant body weight increases compared to controls after 2 weeks on the diet
• male mice are 22% heavier than controls after 20 weeks on a high fat diet
• female mice have a less extreme but still significant weight gain compared to controls after 20 weeks on a high fat diet
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adipose tissue
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• increased amounts of adipose tissue cause the higher weight gain of mice fed a high fat diet for 20 weeks compared to controls fed the same diet
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homeostasis/metabolism
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• mice fed a high-fat diet for 20 weeks have a mean glucose level of 7.25 mmol/l compared to 5.69 mmol/l in control mice
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• mice fed a high-fat diet for 20 weeks have a mean leptin serum level of 15.99 ng/ml compared to 6.41 ng/ml in control mice
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• mice fed a high-fat diet for 20 weeks have a mean ketone bodies level of 1.75 mmol/l compared to 1.29 mmol/l in control mice
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• triglyceride levels are reduced by almost by half in mice fed a chow diet
• triglyceride levels fail to increase as they do in control mice when a high fat diet is administered
• mice fed a high fat diet for 20 weeks have a triglyceride level that is about one-third of that in control mice
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• mice have increased gains in body weight per gram of food consumed after being on a high fat diet for 2 weeks
• the greatest difference in energy expenditure between these mice and control mice is at 4 weeks after the switch to a high fat diet
• differences in energy expenditure gradually decrease but are still significantly less after 20 weeks to the switch to a high fat diet
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• male mice on a high fat diet have significant body weight increases compared to controls after 2 weeks on the diet
• male mice are 22% heavier than controls after 20 weeks on a high fat diet
• female mice have a less extreme but still significant weight gain compared to controls after 20 weeks on a high fat diet
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• mice subjected to hyperinsulinemic conditions after being fed a high fat diet for 20 weeks have twice as much insulin in their sera and 4 times less ability to clear insulin
• the insulin-mediated whole body glucose uptake of these mice under these conditions is reduced by more than half compared to controls
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• a higher uptake of free fatty acids derived from plasma triglyceride leads to a greater increase in adipose tissue mass when mice are fed a high fat diet
• the triglyceride hydrolase actively of the mouse plasma is 78% greater than in controls
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behavior/neurological
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• mice eat 5- to 15% more than controls during the second half of a 20 week feeding of a high fat diet
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