All Phenotypes Asgr2<tm1Her> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Asgr2^tm1Her
targeted mutation 1, Joachim Herz
MGI:1857130

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Asgr2^tm1Her/Asgr2^tm1Her	B6.129S7-Asgr2^tm1Her	MGI:3804627
hm2	Asgr2^tm1Her/Asgr2^tm1Her	involves: 129S7/SvEvBrd * C57BL/6	MGI:2655572
ht3	Asgr2^tm1Her/Asgr2⁺	involves: 129S7/SvEvBrd * C57BL/6	MGI:3511246
cx4	Asgr2^tm1Her/Asgr2^tm1Her St3gal4^tm1.1Jxm/St3gal4^tm1.1Jxm	B6.129-St3gal4^tm1.1Jxm Asgr2^tm1Her	MGI:3804625
cx5	Asgr2^tm1Her/Asgr2^tm1Her Ldlr^tm1Her/Ldlr^tm1Her	involves: 129S7/SvEvBrd * C57BL/6	MGI:3511248

Allelic Composition	Asgr2^tm1Her/Asgr2^tm1Her
Genetic Background	B6.129S7-Asgr2^tm1Her

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Asgr2^tm1Her mutation (2 available); any Asgr2 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:136946 )

• following infection with S. pneumoniae, mice exhibit decreased survival compared to similarly treated wild-type mice

immune system

increased susceptibility to bacterial infection ( J:136946 )

• following infection with S. pneumoniae, mice exhibit decreased survival compared to similarly treated wild-type mice

Allelic Composition	Asgr2^tm1Her/Asgr2^tm1Her
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Asgr2^tm1Her mutation (2 available); any Asgr2 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:21380 , J:35142 )

• homozygotes are viable, fertile, overtly normal, and display no significant accumulation of desialylated glycoproteins or chylomicron remnants in their plasma (J:21380)

• at 6 weeks to 6 months, homozygotes display normal levels of low density lipoprotein receptor-related protein 1 (LRP1) (J:35142)

• in the total absence of normal ASGR function, homozygotes exhibit normal serum concentrations of galactose-terminating glycoproteins; however, other cross-competing endogenous ASGR ligands accumulate in serum (J:35142)

abnormal homeostasis ( J:21380 , J:35142 )

• notably, homozygotes exhibit significantly reduced ASGR1 protein expression in the presence of normal ASGR1 mRNA levels (J:21380)

• although homozygotes still express some residual ASGR1 protein, they are completely unable to clear asialoorosomucoid from their circulation (J:21380)

• however, similar to wild-type mice, homozygotes fail to clear non-desialylated (125)I-labeled orosomucoid (J:21380)

• the residual ASGR1 is expressed at the hepatocellular surface but fails to effectively remove any one of three different radiolabeled ligands within 30 minutes; mutants show a low but detectable residual clearance of 125I-labeled glycoproteins at 4 hours (not mediated by residual ASGR1) (J:35142)

Allelic Composition	Asgr2^tm1Her/Asgr2⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Asgr2^tm1Her mutation (2 available); any Asgr2 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal homeostasis ( J:21380 )

• heterozygotes are overtly normal but express reduced levels of ASGR1 protein, and clear asialoorosomucoid with intermediate efficiency from their circulation relative to wild-type

• however, similar to wild-type mice, heterozygotes fail to clear non-desialylated (125)I-labeled orosomucoid

Allelic Composition	Asgr2^tm1Her/Asgr2^tm1Her St3gal4^tm1.1Jxm/St3gal4^tm1.1Jxm
Genetic Background	B6.129-St3gal4^tm1.1Jxm Asgr2^tm1Her

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Asgr2^tm1Her mutation (2 available); any Asgr2 mutation (20 available)
St3gal4^tm1.1Jxm mutation (1 available); any St3gal4 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:136946 )

N	• unlike in St3gal4^tm1.1Jxm homozygotes, platelet counts are normal

homeostasis/metabolism

abnormal blood coagulation ( J:136946 )

• mice exhibit a longer bleed time compared to in Asgr1^tm1Sau homozygotes that is less than in St3gal4^tm1.1Jxm homozygotes

Allelic Composition	Asgr2^tm1Her/Asgr2^tm1Her Ldlr^tm1Her/Ldlr^tm1Her
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Asgr2^tm1Her mutation (2 available); any Asgr2 mutation (20 available)
Ldlr^tm1Her mutation (19 available); any Ldlr mutation (81 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal lipid homeostasis ( J:21380 )

• double homozygotes display a plasma lipoprotein profile that is similar to that of single Ldlr^tm1Her mutant mice

• notably, double homozygotes do not accumulate any chylomicron remnants in their plasma

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