All Phenotypes Bdnf<tm1Jae> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bdnf^tm1Jae/Bdnf^tm1Jae	B6.129S4-Bdnf^tm1Jae	MGI:3044435
hm2	Bdnf^tm1Jae/Bdnf^tm1Jae	involves: 129S4/SvJae	MGI:2175720
hm3	Bdnf^tm1Jae/Bdnf^tm1Jae	involves: 129S4/SvJae * BALB/c	MGI:3767567
ht4	Bdnf^tm1Jae/Bdnf^tm2(Ntf5)Jae	involves: 129S4/SvJae	MGI:3583671
cx5	Bdnf^tm1Jae/Bdnf^tm1Jae Ntf5^tm1Jae/Ntf5^tm1Jae	involves: 129S4/SvJae	MGI:3761003
cx6	Bdnf^tm1Jae/Bdnf^tm2(Ntf5)Jae Ntrk2^tm1Kln/Ntrk2^tm1Kln	involves: 129S4/SvJae	MGI:3583673
cx7	Bdnf^tm1Jae/Bdnf⁺ Omp^tm1(tTA)Gogo/Omp⁺ Tg(tetO-tetX,lacZ)2Gogo/?	involves: 129S4/SvJae * C57BL/6	MGI:3723444

Allelic Composition	Bdnf^tm1Jae/Bdnf^tm1Jae
Genetic Background	B6.129S4-Bdnf^tm1Jae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnf^tm1Jae mutation (2 available); any Bdnf mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

taste/olfaction

abnormal gustatory papilla taste bud morphology ( J:90280 )

• at P7 homozygous mice have 79% fewer vallate taste buds than wild-type mice

nervous system

abnormal sensory neuron innervation pattern ( J:90280 )

• innervation of the fungiform papillae is reduced with a shortfall in the geniculate ganglion neurons that supply taste neurons to the fungiform papillae

craniofacial

abnormal gustatory papilla taste bud morphology ( J:90280 )

• at P7 homozygous mice have 79% fewer vallate taste buds than wild-type mice

digestive/alimentary system

abnormal gustatory papilla taste bud morphology ( J:90280 )

• at P7 homozygous mice have 79% fewer vallate taste buds than wild-type mice

growth/size/body

abnormal gustatory papilla taste bud morphology ( J:90280 )

• at P7 homozygous mice have 79% fewer vallate taste buds than wild-type mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:17123 , J:82462 )

• most homozygotes die in the second postnatal week, with rare survivors achieving adult stages (J:17123)

behavior/neurological

impaired balance ( J:17123 )

impaired limb coordination ( J:17123 )

head bobbing ( J:17123 )

head tilt ( J:17123 )

hyperactivity ( J:17123 )

circling ( J:17123 )

spinning ( J:17123 )

growth/size/body

abnormal fungiform papillae morphology ( J:82462 )

• loss of fungiform papillae is seen in 2 week old mutants and remaining papillae are smaller

decreased body size ( J:17123 )

• mice are reduced in size compared to control littermates

nervous system

nervous system phenotype ( J:17123 )

N	• no differences are seen in the morphology of the central and peripheral nerve processes from the trigeminal, geniculate, petrose and nodose ganglia at E10.5-11.5

increased neuron apoptosis ( J:123022 )

• at E12 and E14, neuron apoptosis is increased 143% and 155%, respectively, compared to in wild-type mice

abnormal type I vestibular cell ( J:17123 )

• no nerve chalicies are found associated with type I hair cells of the vestibule

small mesencephalic trigeminal nucleus ( J:17123 )

• approximately half of the neurons are lost from the mesencephalic trigeminal nucleus at P14-16

abnormal sensory neuron innervation pattern ( J:82462 )

• loss of outer hair cell innervation in the apex, middle and basal turns of the cochlea

abnormal inner ear vestibular sensory neuron innervation pattern ( J:17123 , J:82462 )

• innervation of the vestibular compartment of the inner ear is severely compromised (J:17123)

• only small fiber bundles enter the saccule, utricle and ampulla of the semicircular ducts compared to controls; the remaining fibers terminate in the connective tissue adjacent to the sensory epithelia of the saccule, utricle and cristae of the semicurcular ducts (J:17123)

• no nerve chalicies are found associated with type I hair cells of the vestibule (J:17123)

• ampullar cristae completely lack innervation (J:82462)

decreased sensory neuron number ( J:17123 , J:25566 )

• the numbers of neurons in many sensory ganglia are reduced compared to controls (J:17123)

• the number of facial motor neurons and sympathetic superior cervical ganglion neurons is not different from controls (J:17123)

• significant loss of all sensory neuron types in the nodose-petrosal, geniculate and vestibular ganglia in homozygous mice (J:25566)

• no difference in the number of facial motor neurons is seen compared to controls (J:25566)

abnormal cochlear ganglion morphology ( J:82462 )

• loss of spiral ganglion neurons by 25% at P0 and 29% at P17 in the cochlea

small geniculate ganglion ( J:25566 , J:82462 )

• approximately half of the neurons are lost from the geniculate ganglion at E18.5 (J:25566)

small petrosal ganglion ( J:25566 )

• greater than half of the neurons are lost from the nodose-petrosal ganglion at E18.5

small trigeminal ganglion ( J:17123 )

• approximately half of the neurons are lost from the trigeminal ganglion at P14-16

small nodose ganglion ( J:17123 , J:25566 , J:82462 )

• approximately 65% of the neurons are lost from the nodose ganglion at P14-16 (J:17123)

• greater than half of the neurons are lost from the nodose-petrosal ganglion at E18.5 (J:25566)

abnormal vestibular ganglion morphology ( J:82462 )

• in co-cultures of wild-type vestibular ganglion neurons with mutant hair cells, very few (2 of 200) wild-type neurons contact a mutant hair cell and diameter of the nerve fiber is thinner and shows less branching on the surface of the mutant hair cell than seen in all wild-type cultures

small vestibular ganglion ( J:17123 , J:25566 )

• approximately 80% of the neurons are lost from the vestibular ganglion at P14-16 (J:17123)

• vestibular neurons appear atrophic (J:17123)

• approximately 75% of the neurons are lost from the vestibular ganglion at E18.5 (J:25566)

abnormal trigeminal nerve morphology ( J:123022 )

• mice exhibit a 43% loss of trigeminal neurons at birth

small L4 dorsal root ganglion ( J:17123 , J:82462 )

• approximately 30% of the neurons are lost from the L4 DRG at P14-16 (J:17123)

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:17123 )

• despite abnormal innervation of the vestibular compartment, the structural integrity of the organ of Corti, macula of the saccula and utricle, and the cristae of the semicircular ducts appear similar to controls

• innervation of the cochlear inner and outer hair cells appears similar to controls

• mice respond to auditory stimuli

abnormal type I vestibular cell ( J:17123 )

• no nerve chalicies are found associated with type I hair cells of the vestibule

abnormal crista ampullaris morphology ( J:82462 )

• ampullar cristae completely lack innervation

abnormal inner ear vestibular sensory neuron innervation pattern ( J:17123 , J:82462 )

• innervation of the vestibular compartment of the inner ear is severely compromised (J:17123)

• no nerve chalicies are found associated with type I hair cells of the vestibule (J:17123)

• ampullar cristae completely lack innervation (J:82462)

deafness ( J:82462 )

• loss of hearing

digestive/alimentary system

abnormal fungiform papillae morphology ( J:82462 )

• loss of fungiform papillae is seen in 2 week old mutants and remaining papillae are smaller

craniofacial

abnormal fungiform papillae morphology ( J:82462 )

• loss of fungiform papillae is seen in 2 week old mutants and remaining papillae are smaller

cellular

increased neuron apoptosis ( J:123022 )

• at E12 and E14, neuron apoptosis is increased 143% and 155%, respectively, compared to in wild-type mice

Allelic Composition	Bdnf^tm1Jae/Bdnf^tm1Jae
Genetic Background	involves: 129S4/SvJae * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnf^tm1Jae mutation (2 available); any Bdnf mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron apoptosis ( J:46125 )

• sympathetic neuron apoptosis is developmentally delayed

• cell death in culture following the withdrawal of NGF is delayed

abnormal neuron morphology ( J:46125 )

• mice exhibit an increased in sympathetic neuron number (21 318+/-1 627 compared to 15 690+/-617 in wild-type mice) and size

increased neuron number ( J:46125 )

cellular

abnormal neuron apoptosis ( J:46125 )

• sympathetic neuron apoptosis is developmentally delayed

• cell death in culture following the withdrawal of NGF is delayed

Allelic Composition	Bdnf^tm1Jae/Bdnf^tm2(Ntf5)Jae
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnf^tm1Jae mutation (2 available); any Bdnf mutation (42 available)
Bdnf^tm2(Ntf5)Jae mutation (0 available); any Bdnf mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:61340 )

• mice are fertile and have a normal appearance

Allelic Composition	Bdnf^tm1Jae/Bdnf^tm1Jae Ntf5^tm1Jae/Ntf5^tm1Jae
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnf^tm1Jae mutation (2 available); any Bdnf mutation (42 available)
Ntf5^tm1Jae mutation (1 available); any Ntf5 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:25566 )

• most homozygous mice die within 48 hours of birth, with only a few surviving up to 10 days of age

growth/size/body

postnatal growth retardation ( J:25566 )

• homozygous mice are the same size as controls at birth, but fail to grow thereafter

nervous system

decreased sensory neuron number ( J:25566 )

• significant loss of all sensory neuron types in the trigeminal, vestibular, nodose-petrosal and geniculate ganglia in homozygous mice

• no statistical difference in the number of facial motor neurons is seen compared to controls

small geniculate ganglion ( J:25566 )

• approximately 95% of the neurons are lost from the geniculate ganglion at E18.5

small petrosal ganglion ( J:25566 )

• approximately 90% of the neurons are lost from the nodose-petrosal ganglion at E18.5

small trigeminal ganglion ( J:25566 )

• approximately 30% of the neurons are lost from the trigeminal ganglion at E18.5

small nodose ganglion ( J:25566 )

• approximately 90% of the neurons are lost from the nodose-petrosal ganglion at E18.5

small vestibular ganglion ( J:25566 )

• approximately 80% of the neurons are lost from the vestibular ganglion at E18.5

abnormal trigeminal nerve morphology ( J:123022 )

• mice exhibit a 25% loss of trigeminal neurons at birth

behavior/neurological

impaired balance ( J:25566 )

impaired coordination ( J:25566 )

Allelic Composition	Bdnf^tm1Jae/Bdnf^tm2(Ntf5)Jae Ntrk2^tm1Kln/Ntrk2^tm1Kln
Genetic Background	involves: 129S4/SvJae

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

head bobbing ( J:61340 )

hyperactivity ( J:61340 )

spinning ( J:61340 )

nervous system

decreased sensory neuron number ( J:61340 )

• observed in the vestibular, nodose-petrosal and geniculate ganglia

Allelic Composition	Bdnf^tm1Jae/Bdnf⁺ Omp^tm1(tTA)Gogo/Omp⁺ Tg(tetO-tetX,lacZ)2Gogo/?
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnf^tm1Jae mutation (2 available); any Bdnf mutation (42 available)
Omp^tm1(tTA)Gogo mutation (1 available); any Omp mutation (27 available)
Tg(tetO-tetX,lacZ)2Gogo mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:124050 )

N	• following doxycycline treatment, terminal-arbor complexity of olfactory nerves is normal

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