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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Agtr1atm1Unc
targeted mutation 1, University of North Carolina
MGI:1857147
Summary 13 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Agtr1atm1Unc/Agtr1atm1Unc involves: 129P2/OlaHsd MGI:4453878
hm2
 		Agtr1atm1Unc/Agtr1atm1Unc involves: 129P2/OlaHsd * C57BL/6 MGI:4454291
hm3
 		Agtr1atm1Unc/Agtr1atm1Unc involves: 129P2/OlaHsd * C57BL/6J MGI:3619337
ht4
 		Agtr1atm1Unc/Agtr1a+ involves: 129P2/OlaHsd * C57BL/6J MGI:3619339
cn5
 		Agtr1atm1Unc/Agtr1atm1Unc
Efemp2tm1.1Hiya/Efemp2tm1.2Hiya
Tg(Tagln-cre)1Her/0 		involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL MGI:5585152
cx6
 		Agtr1atm1Unc/Agtr1atm1Unc
Ldlrtm1Her/Ldlrtm1Her 		B6.129-Ldlrtm1Her Agtr1atm1Unc MGI:4946113
cx7
 		Agtr1atm1Unc/Agtr1atm1Unc
Hprt1tm1(Ggt1-Agtr1)Cof/Y 		involves: 129P2/OlaHsd MGI:3051599
cx8
 		Agtr1atm1Unc/Agtr1atm1Unc
Agtr1btm1Cof/Agtr1btm1Cof
Hprt1tm1(Ggt1-Agtr1)Cof/Y 		involves: 129P2/OlaHsd MGI:3051600
cx9
 		Agtr1atm1Unc/Agtr1atm1Unc
Agtr1btm1Cof/Agtr1btm1Cof 		involves: 129P2/OlaHsd * C57BL/6 MGI:4454286
cx10
 		Agtr1atm1Unc/Agtr1atm1Unc
Agtr2tm1Tin/Y 		involves: 129P2/OlaHsd * C57BL/6 MGI:4454289
cx11
 		Agtr1atm1Unc/Agtr1atm1Unc
Agtr2tm1Tin/Agtr2tm1Tin 		involves: 129P2/OlaHsd * C57BL/6 MGI:4454290
cx12
 		Agtr1atm1Unc/Agtr1atm1Unc
Agtr1btm1Cof/Agtr1btm1Cof
Agtr2tm1Tin/Y 		involves: 129P2/OlaHsd * C57BL/6 MGI:4454285
cx13
 		Agtr1atm1Unc/Agtr1atm1Unc
Agtr1btm1Cof/Agtr1btm1Cof
Agtr2tm1Tin/Agtr2tm1Tin 		involves: 129P2/OlaHsd * C57BL/6 MGI:4454284


Genotype
MGI:4453878
hm1
Allelic
Composition		 Agtr1atm1Unc/Agtr1atm1Unc
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1Unc mutation (1 available); any Agtr1a mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal thalamus morphology ( J:102774 )
• the number of cells in the dorsal lateral geniculate nucleus is decreased compared to in wild-type mice
• however, the size of the neuronal somata is normal
abnormal amygdala morphology ( J:102774 )
• the number of cells in the medial nucleus of the amygdala is decreased compared to in wild-type mice
• however, the size of the neuronal somata is normal




Genotype
MGI:4454291
hm2
Allelic
Composition		 Agtr1atm1Unc/Agtr1atm1Unc
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1Unc mutation (1 available); any Agtr1a mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart rate ( J:137944 )
• Ang II-treated mice exhibit less of an increase in mean arterial blood pressure and heart rate compared with similarly treated wild-type mice
• PE-treated mice exhibit a positive chronotropic response compared with similarly treated wild-type mice
abnormal systemic arterial blood pressure ( J:137944 )
• Ang II-treated mice exhibit less of an increase in mean arterial blood pressure and heart rate compared with similarly treated wild-type mice
• PE-treated mice exhibit a smaller increase in MAP compared with similarly treated wild-type mice

homeostasis/metabolism
abnormal response/metabolism to endogenous compounds ( J:137944 )
• angiotensin II (Ang II)-treated mice exhibit less of an increase in mean arterial blood pressure and heart rate compared with similarly treated wild-type mice
• endothelin 1(Et-1)-treated mice exhibit a positive chronotropic effect unlike wild-type mice
abnormal physiological response to xenobiotic ( J:137944 )
• phenylephrine (PE)-treated mice exhibit a smaller increase in MAP and a positive chronotropic response compared with similarly treated wild-type mice




Genotype
MGI:3619337
hm3
Allelic
Composition		 Agtr1atm1Unc/Agtr1atm1Unc
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1Unc mutation (1 available); any Agtr1a mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal systemic arterial blood pressure ( J:24354 )
• loss of pressure responses to angiotensin II administration
decreased systemic arterial blood pressure ( J:24354 )
• arterial pressure measured by carotid cannula is reduced by 43 mmHg, however homozygotes appear to have a normal heart, kidney and vascular system
decreased systemic arterial systolic blood pressure ( J:24354 )
• systolic blood pressure measured by tail cuff sphygmomanometer is reduced by 24 mmHg




Genotype
MGI:3619339
ht4
Allelic
Composition		 Agtr1atm1Unc/Agtr1a+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1Unc mutation (1 available); any Agtr1a mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal systemic arterial blood pressure ( J:24354 )
• pressure responses to angiotensin II administration are short lived compared to wild-type
decreased systemic arterial blood pressure ( J:24354 )
• arterial pressure measured by carotid cannula is reduced by 17 mmHg
decreased systemic arterial systolic blood pressure ( J:24354 )
• systolic blood pressure measured by tail cuff sphygmomanometer is reduced by 12 mmHg




Genotype
MGI:5585152
cn5
Allelic
Composition		 Agtr1atm1Unc/Agtr1atm1Unc
Efemp2tm1.1Hiya/Efemp2tm1.2Hiya
Tg(Tagln-cre)1Her/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1Unc mutation (1 available); any Agtr1a mutation (40 available)
Efemp2tm1.1Hiya mutation (0 available); any Efemp2 mutation (26 available)
Efemp2tm1.2Hiya mutation (0 available); any Efemp2 mutation (26 available)
Tg(Tagln-cre)1Her mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
increased aorta wall thickness ( J:213282 )
• aortic wall is thicker at 3 months of age compared to single Agtr1a homozygotes




Genotype
MGI:4946113
cx6
Allelic
Composition		 Agtr1atm1Unc/Agtr1atm1Unc
Ldlrtm1Her/Ldlrtm1Her
Genetic
Background		 B6.129-Ldlrtm1Her Agtr1atm1Unc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1Unc mutation (1 available); any Agtr1a mutation (40 available)
Ldlrtm1Her mutation (19 available); any Ldlr mutation (81 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased susceptibility to induced aneurysm formation ( J:170230 )
• angiotensin II-treated mice fed a high-fat diet do not exhibit ascending aortic aneurysms unlike similarly treated Ldlrtm1Her homozygotes
• bone marrow transplant do not alter incidence of angiotensin II-induced ascending aortic aneurysms compared with similarly treated Ldlrtm1Her homozygotes




Genotype
MGI:3051599
cx7
Allelic
Composition		 Agtr1atm1Unc/Agtr1atm1Unc
Hprt1tm1(Ggt1-Agtr1)Cof/Y
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1Unc mutation (1 available); any Agtr1a mutation (40 available)
Hprt1tm1(Ggt1-Agtr1)Cof mutation (0 available); any Hprt1 mutation (1279 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
hypotension ( J:91837 )
• hypotension develops on low salt diet and blood pressure fails to rise on a high salt diet
• fails to correct blood pressure defect caused by homozygous Agtr1tm1Unc

homeostasis/metabolism
decreased urine osmolality ( J:91837 )
• fails to correct defect in urinary concentration caused by homozygous Agtr1tm1Unc

renal/urinary system
decreased urine osmolality ( J:91837 )
• fails to correct defect in urinary concentration caused by homozygous Agtr1tm1Unc




Genotype
MGI:3051600
cx8
Allelic
Composition		 Agtr1atm1Unc/Agtr1atm1Unc
Agtr1btm1Cof/Agtr1btm1Cof
Hprt1tm1(Ggt1-Agtr1)Cof/Y
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1Unc mutation (1 available); any Agtr1a mutation (40 available)
Agtr1btm1Cof mutation (0 available); any Agtr1b mutation (18 available)
Hprt1tm1(Ggt1-Agtr1)Cof mutation (0 available); any Hprt1 mutation (1279 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased renin activity ( J:91837 )
• renin levels reduced by 70% from levels found in mice homozygous for both Agtr1tm1Unc and Agtr1btm1Cof
• renin levels essentially normal

renal/urinary system
kidney cyst ( J:91837 )
• greatly reduced number and size of glomerular and cortical cysts relative to the condition in mice homozygous for both Agtr1tm1Unc and Agtr1btm1Cof
• architecture of the renal cortex is preserved

growth/size/body
kidney cyst ( J:91837 )
• greatly reduced number and size of glomerular and cortical cysts relative to the condition in mice homozygous for both Agtr1tm1Unc and Agtr1btm1Cof
• architecture of the renal cortex is preserved




Genotype
MGI:4454286
cx9
Allelic
Composition		 Agtr1atm1Unc/Agtr1atm1Unc
Agtr1btm1Cof/Agtr1btm1Cof
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1Unc mutation (1 available); any Agtr1a mutation (40 available)
Agtr1btm1Cof mutation (0 available); any Agtr1b mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:137944 )
• fewer than expected mice are present at weaning

cardiovascular system
abnormal kidney vasculature morphology ( J:137944 )
• mice exhibit media hyperplasia of small and medium vessels unlike wild-type mice
decreased heart weight ( J:137944 )
• compared with wild-type mice and Agtr1atm1Unc homozygotes
abnormal systemic arterial blood pressure ( J:137944 )
• Ang II-treated mice exhibit an almost completely blunted increase in mean arterial blood pressure (MAP) and heart rate with an increased time to normalization of MAP compared with similarly treated wild-type mice
• PE-treated mice exhibit a smaller increase in MAP compared with similarly treated wild-type mice

homeostasis/metabolism
abnormal circulating protein level ( J:137944 )
• serum levels of Ang II are increased compared to in wild-type mice and Agtr1btm1Cof homozygotes
abnormal response/metabolism to endogenous compounds ( J:137944 )
• angiotensin II (Ang II)-treated mice exhibit an almost completely blunted increase in mean arterial blood pressure (MAP) and heart rate with an increased time to normalization of MAP compared with similarly treated wild-type mice
abnormal physiological response to xenobiotic ( J:137944 )
• phenylephrine (PE)-treated mice exhibit a smaller increase in MAP compared with similarly treated wild-type mice
• however, PE-treated mice exhibit a negative chronotropic response as in wild-type mice

renal/urinary system
abnormal kidney vasculature morphology ( J:137944 )
• mice exhibit media hyperplasia of small and medium vessels unlike wild-type mice
kidney cyst ( J:137944 )
• mice exhibit cystic dilated cavities unlike wild-type mice
kidney inflammation ( J:137944 )
• mice exhibit prominent renal mononuclear infiltrations with partially blastic appearance and a high rate of partial mitosis unlike wild-type mice
increased glomerular capsule space ( J:137944 )
• severely dilated Bowman's space
renal glomerulus atrophy ( J:137944 )
• multifocal and focally extensive glomeruli atrophy
dilated renal tubule ( J:137944 )
• partially dilated tubular lumina unlike in wild-type mice

growth/size/body
decreased body weight ( J:137944 )
kidney cyst ( J:137944 )
• mice exhibit cystic dilated cavities unlike wild-type mice

immune system
kidney inflammation ( J:137944 )
• mice exhibit prominent renal mononuclear infiltrations with partially blastic appearance and a high rate of partial mitosis unlike wild-type mice




Genotype
MGI:4454289
cx10
Allelic
Composition		 Agtr1atm1Unc/Agtr1atm1Unc
Agtr2tm1Tin/Y
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1Unc mutation (1 available); any Agtr1a mutation (40 available)
Agtr2tm1Tin mutation (0 available); any Agtr2 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart rate ( J:137944 )
• Ang II-treated mice exhibit less of an increase in mean arterial blood pressure and heart rate compared with similarly treated wild-type mice
abnormal systemic arterial blood pressure ( J:137944 )
• Ang II-treated mice exhibit less of an increase in mean arterial blood pressure and heart rate compared with similarly treated wild-type mice

homeostasis/metabolism
abnormal circulating protein level ( J:137944 )
• serum levels of Ang II are increased compared to in wild-type mice
abnormal response/metabolism to endogenous compounds ( J:137944 )
• angeotensin II (Ang II)-treated mice exhibit less of an increase in mean arterial blood pressure and heart rate compared with similarly treated wild-type mice

renal/urinary system
increased glomerular capsule space ( J:137944 )
• mice exhibit cystic dilated Bowman's space unlike wild-type mice
renal glomerulus atrophy ( J:137944 )
• mice exhibit multifocal glomeruli atrophy unlike wild-type mice




Genotype
MGI:4454290
cx11
Allelic
Composition		 Agtr1atm1Unc/Agtr1atm1Unc
Agtr2tm1Tin/Agtr2tm1Tin
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1Unc mutation (1 available); any Agtr1a mutation (40 available)
Agtr2tm1Tin mutation (0 available); any Agtr2 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart rate ( J:137944 )
• Ang II-treated mice exhibit less of an increase in mean arterial blood pressure and heart rate compared with similarly treated wild-type mice
abnormal systemic arterial blood pressure ( J:137944 )
• Ang II-treated mice exhibit less of an increase in mean arterial blood pressure and heart rate compared with similarly treated wild-type mice

homeostasis/metabolism
abnormal circulating protein level ( J:137944 )
• serum levels of Ang II are increased compared to in wild-type mice
abnormal response/metabolism to endogenous compounds ( J:137944 )
• angeotensin II (Ang II)-treated mice exhibit less of an increase in mean arterial blood pressure and heart rate compared with similarly treated wild-type mice

renal/urinary system
increased glomerular capsule space ( J:137944 )
• mice exhibit cystic dilated Bowman's space unlike wild-type mice
renal glomerulus atrophy ( J:137944 )
• mice exhibit multifocal glomeruli atrophy unlike wild-type mice




Genotype
MGI:4454285
cx12
Allelic
Composition		 Agtr1atm1Unc/Agtr1atm1Unc
Agtr1btm1Cof/Agtr1btm1Cof
Agtr2tm1Tin/Y
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1Unc mutation (1 available); any Agtr1a mutation (40 available)
Agtr1btm1Cof mutation (0 available); any Agtr1b mutation (18 available)
Agtr2tm1Tin mutation (0 available); any Agtr2 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:137944 )
• fewer than expected mice are present at weaning

cardiovascular system
abnormal heart rate ( J:137944 )
• compared with wild-type mice and Agtr1atm1Unc homozygotes
decreased heart rate ( J:137944 )
• compared with wild-type mice and Agtr1atm1Unc homozygotes
abnormal systemic arterial blood pressure ( J:137944 )
• Ang II-treated mice exhibit an almost completely blunted increase in mean arterial blood pressure (MAP) and heart rate with a shortened time to peak MAP and an increased time to normalization of MAP compared with similarly treated wild-type mice
• PE-treated mice exhibit a smaller increase in MAP compared with similarly treated wild-type mice
decreased mean systemic arterial blood pressure ( J:137944 )
• compared with wild-type mice and Agtr1atm1Unc homozygotes

homeostasis/metabolism
abnormal response/metabolism to endogenous compounds ( J:137944 )
• angiotensin II (Ang II)-treated mice exhibit an almost completely blunted increase in mean arterial blood pressure (MAP) and heart rate with a shortened time to peak MAP and an increased time to normalization of MAP compared with similarly treated wild-type mice
• endothelin 1 (Et-1)-treated mice exhibit a positive chronotropic effect unlike wild-type mice
abnormal physiological response to xenobiotic ( J:137944 )
• phenylephrine (PE)-treated mice exhibit a smaller increase in MAP and fail to exhibit any chronotropic response compared with similarly treated wild-type mice

renal/urinary system
hydronephrosis ( J:137944 )
• in some mice
decreased kidney weight ( J:137944 )
• compared with wild type mice and Agtr1atm1Unc Agtr1btm1Cof double homozygotes

growth/size/body
decreased body weight ( J:137944 )
• compared with wild-type mice that is not as severe as in Agtr1atm1Unc Agtr1btm1Cof double homozygotes




Genotype
MGI:4454284
cx13
Allelic
Composition		 Agtr1atm1Unc/Agtr1atm1Unc
Agtr1btm1Cof/Agtr1btm1Cof
Agtr2tm1Tin/Agtr2tm1Tin
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1Unc mutation (1 available); any Agtr1a mutation (40 available)
Agtr1btm1Cof mutation (0 available); any Agtr1b mutation (18 available)
Agtr2tm1Tin mutation (0 available); any Agtr2 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:137944 )
• fewer than expected mice are present at weaning

cardiovascular system
abnormal heart rate ( J:137944 )
• compared with wild-type mice and Agtr1atm1Unc homozygotes
decreased heart rate ( J:137944 )
• compared with wild-type mice and Agtr1atm1Unc homozygotes
abnormal systemic arterial blood pressure ( J:137944 )
• Ang II-treated mice exhibit an almost completely blunted increase in mean arterial blood pressure (MAP) and heart rate with a shortened time to peak MAP and an increased time to normalization of MAP compared with similarly treated wild-type mice
• PE-treated mice exhibit a smaller increase in MAP compared with similarly treated wild-type mice
decreased mean systemic arterial blood pressure ( J:137944 )
• compared with wild-type mice and Agtr1atm1Unc homozygotes

homeostasis/metabolism
abnormal response/metabolism to endogenous compounds ( J:137944 )
• angiotensin II (Ang II)-treated mice exhibit an almost completely blunted increase in mean arterial blood pressure (MAP) and heart rate with a shortened time to peak MAP and an increased time to normalization of MAP compared with similarly treated wild-type mice
• endothelin 1 (Et-1)-treated mice exhibit a positive chronotropic effect unlike wild-type mice
abnormal physiological response to xenobiotic ( J:137944 )
• phenylephrine (PE)-treated mice exhibit a smaller increase in MAP and fail to exhibit any chronotropic response compared with similarly treated wild-type mice

renal/urinary system
hydronephrosis ( J:137944 )
• in some mice
decreased kidney weight ( J:137944 )
• compared with wild type mice and Agtr1atm1Unc Agtr1btm1Cof double homozygotes

growth/size/body
decreased body weight ( J:137944 )
• compared with wild-type mice that is not as severe as in Agtr1atm1Unc Agtr1btm1Cof double homozygotes




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Send questions and comments to User Support. 		last database update
12/10/2024
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