Analysis Tools
endocrine/exocrine glands
| N |
• normal gonadotrope cellularity
|
|
• lactotropes are reduced in number in females
|
|
• lactotropes were undetected in males
|
|
• reduced somatotrope cellularity
|
|
• thyotrope hyperplasia and hypertrophy
|
|
• disorganized follicles
|
 |
• seminal glands were not readily visible, consistent with testosterone deficiency
|
 |
• follicles were reduced in size
• no progress beyond the preantral stage
|
small ovary
(
J:28450
)
|
|
|
|
|
• development of the tubules ceased perinatally
|
small testis
(
J:28450
)
|
|
• size reduction observed at 8 weeks of age
|
|
• hypothyroid
|
growth/size/body
|
• mice were approximately half the size of wild-type littermates at 4.5 weeks of age
|
|
• first evident between 2 and 3 weeks of age
|
|
• no gender difference in size, putatively due to the decrease in testosterone levels
|
homeostasis/metabolism
|
• serum testosterone was undetected in male mice
|
reproductive system
|
|
• spermatogenesis was blocked at meiosis I
|
|
|
• seminal glands were not readily visible, consistent with testosterone deficiency
|
|
|
• follicles were reduced in size
• no progress beyond the preantral stage
|
small ovary
(
J:28450
)
|
|
|
|
|
• development of the tubules ceased perinatally
|
small testis
(
J:28450
)
|
|
• size reduction observed at 8 weeks of age
|
|
|
• underdeveloped and threadlike at 3 weeks of age
|
nervous system
|
• lactotropes are reduced in number in females
|
|
• lactotropes were undetected in males
|
|
• reduced somatotrope cellularity
|
|
• thyotrope hyperplasia and hypertrophy
|
cellular
|
|
• spermatogenesis was blocked at meiosis I
|
