reproductive system
|
• homozygous females developed postpartum abnormalities of the uterus, including persistence of nodules containing type I collagen in the uterine wall, caused by a failure of collagen resorption
|
|
• occasionally, virgin homozygous females showed small accumulations of collagen in the myometrium of the uterus
|
• mutant females had slightly reduced litter sizes and significantly fewer litters than wild-type females
|
integument
• homozygotes developed patchy hair loss
|
• homozygotes were viable, resistant to collagenase action, and developed normally to young adulthood
• at ~7 months, homozygotes developed dermal fibrosis, similar to scleroderma, and skin ulcerations
• mutant skin displayed a significant increase in collagen extending through to the deep dermis
• homozygous females developed similar but milder skin abnormalities relative to age-matched homozygous males
|