Analysis Tools
hematopoietic system
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• homozygotes show a 50% decrease in granulopoietic precursor cells in the bone marrow, with reduced levels of granulocyte, macrophage, and blast progenitor cells
• G-CSF administration reverses the granulopoietic defect: one day of G-CSF administration increases circulating neutrophil levels to normal, and after 4 days of G-CSF administration, mutant bone marrows are morphologically indistinguishable from wild-type marrows
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• homozygotes are viable, fertile, and developmentally normal with no overt signs of disease or significant changes in hemoglobin or platelet levels
• however, homozygotes exhibit leukopenia as a result of significant selective neutropenia
• some homozygotes exhibit reduced circulating lymphocyte levels; however, these changes are inconsistent
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• homozygotes exhibit a severe chronic neutropenia, with blood neutrophil levels reduced to ~30% of wild-type levels
• however, no significant changes in circulating eosinophil numbers are observed
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• homozygotes display significantly reduced monocyte levels relative to wild-type mice
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• homozygotes exhibit impaired neutrophil mobilization in response to a single dose of G-CSF, with only 21% of wild-type circulating neutrophil levels at 3 hrs post-treatment
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immune system
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• homozygotes show a 50% decrease in granulopoietic precursor cells in the bone marrow, with reduced levels of granulocyte, macrophage, and blast progenitor cells
• G-CSF administration reverses the granulopoietic defect: one day of G-CSF administration increases circulating neutrophil levels to normal, and after 4 days of G-CSF administration, mutant bone marrows are morphologically indistinguishable from wild-type marrows
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• homozygotes are viable, fertile, and developmentally normal with no overt signs of disease or significant changes in hemoglobin or platelet levels
• however, homozygotes exhibit leukopenia as a result of significant selective neutropenia
• some homozygotes exhibit reduced circulating lymphocyte levels; however, these changes are inconsistent
|
|
• homozygotes exhibit a severe chronic neutropenia, with blood neutrophil levels reduced to ~30% of wild-type levels
• however, no significant changes in circulating eosinophil numbers are observed
|
|
• homozygotes display significantly reduced monocyte levels relative to wild-type mice
|
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• homozygotes exhibit impaired neutrophil mobilization in response to a single dose of G-CSF, with only 21% of wild-type circulating neutrophil levels at 3 hrs post-treatment
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• homozygotes display a significantly impaired ability to control infection with Listeria monocytogenes, as shown by a 50% mortality rate at day 5 post-inoculation as well as diminished neutrophil and delayed monocyte increases in blood and reduced infection-driven granulopoiesis
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