All Phenotypes Dnmt1<tm1Jae> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dnmt1^tm1Jae
targeted mutation 1, Rudolf Jaenisch
MGI:1857157

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dnmt1^tm1Jae/Dnmt1^tm1Jae	involves: 129S4/SvJae	MGI:2167258
ht2	Dnmt1^tm1Jae/Dnmt1^tm1Pwl	involves: 129S4/SvJae	MGI:3848452
cx3	Dnmt1^tm1Jae/Dnmt1^tm1Pwl Mlh1^tm1Lisk/Mlh1^tm1Lisk	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6	MGI:3848460
cx4	Dnmt1^tm1Jae/Dnmt1⁺ Mlh1^tm1Lisk/Mlh1^tm1Lisk	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6	MGI:3848459
cx5	Apc^Min/Apc⁺ Dnmt1^tm1Jae/Dnmt1^tm1Pwl	involves: 129S4/SvJae * C57BL/6J	MGI:3848453
cx6	Apc^Min/Apc⁺ Dnmt1^tm1Jae/Dnmt1⁺	involves: 129S4/SvJae * C57BL/6J	MGI:3848451

Allelic Composition	Dnmt1^tm1Jae/Dnmt1^tm1Jae
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt1^tm1Jae mutation (2 available); any Dnmt1 mutation (110 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:1157 )

• die prior to E11

embryo

increased embryonic tissue cell apoptosis ( J:1157 )

• increase in cell death in embryos

embryonic growth arrest ( J:1157 )

• embryos fail to develop beyond the stage characteristic of normal E9.5 embryos

abnormal embryonic tissue morphology ( J:1157 )

• 2/3 of embryos show a structure protruding from the lower abdomen

pale yolk sac ( J:1157 )

• yolk sacs lack visible blood or blood vasculature

small visceral yolk sac ( J:1157 )

• small yolk sac

cellular

increased embryonic tissue cell apoptosis ( J:1157 )

• increase in cell death in embryos

decreased cell proliferation ( J:1157 )

• fewer mitotic figures in embryos

abnormal DNA methylation ( J:1157 )

• total cytosine methylation is about 30% of the level in wild-type

abnormal imprinting ( J:110857 )

• Ifg2 is not expressed due to altered imprinting

Allelic Composition	Dnmt1^tm1Jae/Dnmt1^tm1Pwl
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt1^tm1Jae mutation (2 available); any Dnmt1 mutation (110 available)
Dnmt1^tm1Pwl mutation (0 available); any Dnmt1 mutation (110 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:75230 )

N	• mice exhibit normal size and weight

Allelic Composition	Dnmt1^tm1Jae/Dnmt1^tm1Pwl Mlh1^tm1Lisk/Mlh1^tm1Lisk
Genetic Background	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:75745 )

• mice exhibit poorer survival than in Mlh1^tm1Lisk homozygotes

neoplasm

neoplasm ( J:75745 )

N	• no mice develop intestinal tumors

increased lymphoma incidence ( J:75745 )

• 90% of mice develop lymphomas

• mice develop lymphomas at an earlier age than in Mlh1^tm1Lisk homozygotes

Allelic Composition	Dnmt1^tm1Jae/Dnmt1⁺ Mlh1^tm1Lisk/Mlh1^tm1Lisk
Genetic Background	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt1^tm1Jae mutation (2 available); any Dnmt1 mutation (110 available)
Mlh1^tm1Lisk mutation (2 available); any Mlh1 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:75745 )

• mice exhibit poorer survival than in Mlh1^tm1Lisk homozygotes

neoplasm

increased intestinal adenocarcinoma incidence ( J:75745 )

• 41% of mice develop intestinal tumors

increased intestinal adenoma incidence ( J:75745 )

• 41% of mice develop intestinal tumors

increased lymphoma incidence ( J:75745 )

• 56% of mice develop lymphomas

• mice develop lymphomas at an earlier age than in Mlh1^tm1Lisk homozygotes

digestive/alimentary system

increased intestinal adenocarcinoma incidence ( J:75745 )

• 41% of mice develop intestinal tumors

increased intestinal adenoma incidence ( J:75745 )

• 41% of mice develop intestinal tumors

Allelic Composition	Apc^Min/Apc⁺ Dnmt1^tm1Jae/Dnmt1^tm1Pwl
Genetic Background	involves: 129S4/SvJae * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (156 available)
Dnmt1^tm1Jae mutation (2 available); any Dnmt1 mutation (110 available)
Dnmt1^tm1Pwl mutation (0 available); any Dnmt1 mutation (110 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

digestive/alimentary phenotype ( J:75230 )

N	• no intestinal polyps are observed unlike in Apc^Min heterozygotes

Allelic Composition	Apc^Min/Apc⁺ Dnmt1^tm1Jae/Dnmt1⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

intestine polyps ( J:75230 )

• mice exhibit fewer intestinal polyps compared with Apc^Min heterozygotes

• polyps are smaller than in Apc^Min heterozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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