mortality/aging
• die prior to E11
|
embryo
• increase in cell death in embryos
|
• embryos fail to develop beyond the stage characteristic of normal E9.5 embryos
|
• 2/3 of embryos show a structure protruding from the lower abdomen
|
pale yolk sac
(
J:1157
)
• yolk sacs lack visible blood or blood vasculature
|
• small yolk sac
|
cellular
• increase in cell death in embryos
|
• fewer mitotic figures in embryos
|
• total cytosine methylation is about 30% of the level in wild-type
|
• Ifg2 is not expressed due to altered imprinting
|