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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dnmt1tm1Jae
targeted mutation 1, Rudolf Jaenisch
MGI:1857157
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dnmt1tm1Jae/Dnmt1tm1Jae involves: 129S4/SvJae MGI:2167258
ht2
 		Dnmt1tm1Jae/Dnmt1tm1Pwl involves: 129S4/SvJae MGI:3848452
cx3
 		Dnmt1tm1Jae/Dnmt1tm1Pwl
Mlh1tm1Lisk/Mlh1tm1Lisk 		involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 MGI:3848460
cx4
 		Dnmt1tm1Jae/Dnmt1+
Mlh1tm1Lisk/Mlh1tm1Lisk 		involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 MGI:3848459
cx5
 		ApcMin/Apc+
Dnmt1tm1Jae/Dnmt1tm1Pwl 		involves: 129S4/SvJae * C57BL/6J MGI:3848453
cx6
 		ApcMin/Apc+
Dnmt1tm1Jae/Dnmt1+ 		involves: 129S4/SvJae * C57BL/6J MGI:3848451


Genotype
MGI:2167258
hm1
Allelic
Composition		 Dnmt1tm1Jae/Dnmt1tm1Jae
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt1tm1Jae mutation (2 available); any Dnmt1 mutation (112 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
increased embryonic tissue cell apoptosis ( J:1157 )
• increase in cell death in embryos
embryonic growth arrest ( J:1157 )
• embryos fail to develop beyond the stage characteristic of normal E9.5 embryos
abnormal embryonic tissue morphology ( J:1157 )
• 2/3 of embryos show a structure protruding from the lower abdomen
pale yolk sac ( J:1157 )
• yolk sacs lack visible blood or blood vasculature
small visceral yolk sac ( J:1157 )
• small yolk sac

cellular
increased embryonic tissue cell apoptosis ( J:1157 )
• increase in cell death in embryos
decreased cell proliferation ( J:1157 )
• fewer mitotic figures in embryos
abnormal DNA methylation ( J:1157 )
• total cytosine methylation is about 30% of the level in wild-type
abnormal imprinting ( J:110857 )
• Ifg2 is not expressed due to altered imprinting




Genotype
MGI:3848452
ht2
Allelic
Composition		 Dnmt1tm1Jae/Dnmt1tm1Pwl
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt1tm1Jae mutation (2 available); any Dnmt1 mutation (112 available)
Dnmt1tm1Pwl mutation (0 available); any Dnmt1 mutation (112 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
growth/size/body region phenotype ( J:75230 )
N
• mice exhibit normal size and weight




Genotype
MGI:3848460
cx3
Allelic
Composition		 Dnmt1tm1Jae/Dnmt1tm1Pwl
Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic
Background		 involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt1tm1Jae mutation (2 available); any Dnmt1 mutation (112 available)
Dnmt1tm1Pwl mutation (0 available); any Dnmt1 mutation (112 available)
Mlh1tm1Lisk mutation (2 available); any Mlh1 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:75745 )
• mice exhibit poorer survival than in Mlh1tm1Lisk homozygotes

neoplasm
neoplasm ( J:75745 )
N
• no mice develop intestinal tumors
increased lymphoma incidence ( J:75745 )
• 90% of mice develop lymphomas
• mice develop lymphomas at an earlier age than in Mlh1tm1Lisk homozygotes




Genotype
MGI:3848459
cx4
Allelic
Composition		 Dnmt1tm1Jae/Dnmt1+
Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic
Background		 involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt1tm1Jae mutation (2 available); any Dnmt1 mutation (112 available)
Mlh1tm1Lisk mutation (2 available); any Mlh1 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:75745 )
• mice exhibit poorer survival than in Mlh1tm1Lisk homozygotes

neoplasm
increased intestinal adenocarcinoma incidence ( J:75745 )
• 41% of mice develop intestinal tumors
increased intestinal adenoma incidence ( J:75745 )
• 41% of mice develop intestinal tumors
increased lymphoma incidence ( J:75745 )
• 56% of mice develop lymphomas
• mice develop lymphomas at an earlier age than in Mlh1tm1Lisk homozygotes

digestive/alimentary system
increased intestinal adenocarcinoma incidence ( J:75745 )
• 41% of mice develop intestinal tumors
increased intestinal adenoma incidence ( J:75745 )
• 41% of mice develop intestinal tumors




Genotype
MGI:3848453
cx5
Allelic
Composition		 ApcMin/Apc+
Dnmt1tm1Jae/Dnmt1tm1Pwl
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (157 available)
Dnmt1tm1Jae mutation (2 available); any Dnmt1 mutation (112 available)
Dnmt1tm1Pwl mutation (0 available); any Dnmt1 mutation (112 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
digestive/alimentary phenotype ( J:75230 )
N
• no intestinal polyps are observed unlike in ApcMin heterozygotes




Genotype
MGI:3848451
cx6
Allelic
Composition		 ApcMin/Apc+
Dnmt1tm1Jae/Dnmt1+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (157 available)
Dnmt1tm1Jae mutation (2 available); any Dnmt1 mutation (112 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
intestine polyps ( J:75230 )
• mice exhibit fewer intestinal polyps compared with ApcMin heterozygotes
• polyps are smaller than in ApcMin heterozygotes




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory