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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fcgr2btm1Ttk
targeted mutation 1, Toshiyuki Takai
MGI:1857166
Summary 19 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fcgr2btm1Ttk/Fcgr2btm1Ttk B6.129S4-Fcgr2btm1Ttk MGI:2448998
hm2
 		Fcgr2btm1Ttk/Fcgr2btm1Ttk C.129S4-Fcgr2btm1Ttk MGI:2448997
hm3
 		Fcgr2btm1Ttk/Fcgr2btm1Ttk involves: 129S4/SvJae MGI:2448996
hm4
 		Fcgr2btm1Ttk/Fcgr2btm1Ttk Not Specified MGI:5432107
cn5
 		Fcgr2btm1Ttk/Fcgr2btm1Ttk
Traf3ip2tm2Sbn/Traf3ip2tm2Sbn
Cd79atm1(cre)Reth/Cd79a+ 		involves: 129S4/SvJae * BALB/c * C57BL/6 MGI:5462351
cx6
 		Fcgr2btm1Ttk/Fcgr2btm1Ttk
Sle21129P2/Ola/Sle21129P2/Ola 		B6.129S4-Fcgr2btm1Ttk MGI:5427951
cx7
 		Fcer1atm1Knt/Fcer1atm1Knt
Fcer2atm1Max/Fcer2atm1Max
Fcgr1tm1Jsv/Fcgr1tm1Jsv
Fcgr2btm1Ttk/Fcgr2btm1Ttk
Fcgr3tm1Jsv/Fcgr3tm1Jsv 		B6.Cg-Fcgr2btm1Ttk Fcgr3tm1Jsv Fcer1atm1Knt Fcgr1tm1Jsv Fcer2atm1Max MGI:3851204
cx8
 		Fcgr2btm1Ttk/Fcgr2btm1Ttk
Tlr7tm1Flv/Y
X/Yaa 		B6.Cg-Fcgr2btm1Ttk Tlr7tm1Flv Yaa MGI:5488508
cx9
 		Fcgr2btm1Ttk/Fcgr2btm1Ttk
X/Yaa 		B6.Cg-Fcgr2btm1Ttk Yaa MGI:5488509
cx10
 		Fcgr2btm1Ttk/Fcgr2btm1Ttk
Traf3ip2tm1Sbn/Traf3ip2tm1Sbn 		involves: 129 * 129S4/SvJae * C57BL/6 MGI:5462346
cx11
 		Fcgr2btm1Ttk/Fcgr2btm1Ttk
Traf3ip2tm1Sbn/Traf3ip2+ 		involves: 129 * 129S4/SvJae * C57BL/6 MGI:5462253
cx12
 		Fcgr2btm1Ttk/Fcgr2btm1.2Jsv
Sle21129P2/Ola/Sle21C57BL/6 		involves: 129P2/Ola * 129S4/SvJae * C57BL/6 * FVB/N MGI:5427953
cx13
 		Fcgr1tm1Jsv/Fcgr1tm1Jsv
Fcgr2btm1Ttk/Fcgr2btm1Ttk
Fcgr3tm1Jsv/Fcgr3tm1Jsv 		involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6 MGI:2664970
cx14
 		Fcgr2btm1Ttk/Fcgr2btm1Ttk
Il17atm1Yiw/Il17a+ 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:5462357
cx15
 		Fcgr2btm1Ttk/Fcgr2btm1Ttk
Il17atm1Yiw/Il17atm1Yiw 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:5462360
cx16
 		Fcgr2btm1Ttk/Fcgr2btm1Ttk
Pdcd1tm1Hon/Pdcd1tm1Hon 		involves: 129S2/SvPas * 129S4/SvJae * BALB/c MGI:5574062
cx17
 		Fcgr2btm1Ttk/Fcgr2btm1Ttk
Traf3ip2tm2Sbn/Traf3ip2+ 		involves: 129S4/SvJae * BALB/c * C57BL/6 MGI:5462356
cx18
 		Fcgr2btm1Ttk/Fcgr2btm1Ttk
Tg(Ins2-TFRC/OVA)296Wehi/0 		involves: 129S4/SvJae * C57BL/6 MGI:3784429
cx19
 		Fcgr2btm1Ttk/Fcgr2b+
X/Yaa 		involves: 129S4/SvJae * C57BL/6 * SB/Le MGI:4360218


Genotype
MGI:2448998
hm1
Allelic
Composition		 Fcgr2btm1Ttk/Fcgr2btm1Ttk
Genetic
Background		 B6.129S4-Fcgr2btm1Ttk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2btm1Ttk mutation (7 available); any Fcgr2b mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:64152 )
• death by 9 months, with evidence of clear distress, including: hunched posture, edema, dehydration

behavior/neurological
abnormal seizure response to electrical stimulation ( J:169028 )
• mice exhibit lower electroconvulsive threshold to generalized seizure compared with wild-type mice
maximal tonic hindlimb extension seizures ( J:169028 )
• in response to transcorneal electrical stimulation
tonic-clonic seizures ( J:169028 )
• in response to transcorneal electrical stimulation

digestive/alimentary system
salivary gland inflammation ( J:64152 )
• pathological examination at 8 months of age showed inflammatory cell infiltration in the salivary gland

endocrine/exocrine glands
salivary gland inflammation ( J:64152 )
• pathological examination at 8 months of age showed inflammatory cell infiltration in the salivary gland
pancreas inflammation ( J:64152 )
• pathological examination at 8 months of age showed inflammatory cell infiltration in the pancreas

growth/size/body
decreased body weight ( J:64152 )
• reduced weight, evident with signs of distress near death
enlarged spleen ( J:64152 )

hematopoietic system
anemia ( J:64152 )
• evident at 8 months of age
increased immunoglobulin level ( J:64152 )
• high serum titers of antinuclear antibodies (ANA)

homeostasis/metabolism
increased urine protein level ( J:64152 )
• evident beginning at 5 months of age in 40% of mice and in 90% of mice at 9 months of age

immune system
increased immunoglobulin level ( J:64152 )
• high serum titers of antinuclear antibodies (ANA)
abnormal hypersensitivity reaction ( J:64152 )
• pathological examination at 8 months of age showed severe multiorgan inflammatory disease
increased inflammatory response ( J:64152 )
• pathological examination at 8 months of age showed severe multiorgan inflammatory disease with inflammatory cell infiltration in the lungs, kidneys, salivary glands, pancreas, liver, tongue, and muscle
salivary gland inflammation ( J:64152 )
• pathological examination at 8 months of age showed inflammatory cell infiltration in the salivary gland
pancreas inflammation ( J:64152 )
• pathological examination at 8 months of age showed inflammatory cell infiltration in the pancreas
liver inflammation ( J:64152 )
• pathological examination at 8 months of age showed inflammatory cell infiltration in the liver
kidney inflammation ( J:64152 )
• pathological examination at 8 months of age showed inflammatory cell infiltration in the kidney
glomerulonephritis ( J:64152 )
• evident at 8 months
lung inflammation ( J:64152 )
• pathological examination at 8 months of age showed inflammatory cell infiltration in the lung

renal/urinary system
increased urine protein level ( J:64152 )
• evident beginning at 5 months of age in 40% of mice and in 90% of mice at 9 months of age
kidney inflammation ( J:64152 )
• pathological examination at 8 months of age showed inflammatory cell infiltration in the kidney
glomerulonephritis ( J:64152 )
• evident at 8 months

respiratory system
lung inflammation ( J:64152 )
• pathological examination at 8 months of age showed inflammatory cell infiltration in the lung

cardiovascular system
vascular inflammation ( J:64152 )
• pathological examination at 8 months of age showed systemic vasculitis

liver/biliary system
liver inflammation ( J:64152 )
• pathological examination at 8 months of age showed inflammatory cell infiltration in the liver

nervous system
abnormal seizure response to electrical stimulation ( J:169028 )
• mice exhibit lower electroconvulsive threshold to generalized seizure compared with wild-type mice
maximal tonic hindlimb extension seizures ( J:169028 )
• in response to transcorneal electrical stimulation
tonic-clonic seizures ( J:169028 )
• in response to transcorneal electrical stimulation




Genotype
MGI:2448997
hm2
Allelic
Composition		 Fcgr2btm1Ttk/Fcgr2btm1Ttk
Genetic
Background		 C.129S4-Fcgr2btm1Ttk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2btm1Ttk mutation (7 available); any Fcgr2b mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:64152 )
N
• mice have life spans comparable to wild-type littermates

immune system
decreased susceptibility to parasitic infection ( J:120905 )
• mice infected with Plasmodium chabaudi chabaudi exhibit lower peak levels of parasitemia and quicker resolution, less severe anemia, less severe hypothermia, increased phagocytosis of malarial parasites by macrophages, increased TNF-alpha production from macrophages ingesting malaria parasite and increased anti-malarial antibody titers compared with wild-type mice

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
malaria DOID:12365 J:120905




Genotype
MGI:2448996
hm3
Allelic
Composition		 Fcgr2btm1Ttk/Fcgr2btm1Ttk
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2btm1Ttk mutation (7 available); any Fcgr2b mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal mast cell physiology ( J:31133 )
• mast cells highly sensitive to IgG-triggered degranulation as compared to wild-type littermate controls
increased IgA level ( J:31133 )
• elevated IgA levels in response to both T-dependent and T-independent antigens
increased IgG level ( J:31133 )
• elevated IgG1, IgG2a, IgG2b, IgG3 levels in response to both T-dependent and T-independent antigens
increased IgM level ( J:31133 )
• elevated IgM levels in response to both T-dependent and T-independent antigens
increased susceptibility to type I hypersensitivity reaction ( J:31133 )
• enhanced response to IgG1-dependent passive systemic anaphylaxis, however development of myeloid and lymphoid cell lineages was normal

hematopoietic system
abnormal mast cell physiology ( J:31133 )
• mast cells highly sensitive to IgG-triggered degranulation as compared to wild-type littermate controls
increased IgA level ( J:31133 )
• elevated IgA levels in response to both T-dependent and T-independent antigens
increased IgG level ( J:31133 )
• elevated IgG1, IgG2a, IgG2b, IgG3 levels in response to both T-dependent and T-independent antigens
increased IgM level ( J:31133 )
• elevated IgM levels in response to both T-dependent and T-independent antigens




Genotype
MGI:5432107
hm4
Allelic
Composition		 Fcgr2btm1Ttk/Fcgr2btm1Ttk
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2btm1Ttk mutation (7 available); any Fcgr2b mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
increased susceptibility to induced arthritis ( J:106191 )
• increased knee joint inflammation 3 days after arthritis induction using immune complexes
• 300% more infiltrating cells than in controls
• inflammation persists without improvement for 7 days
• more proteoglycan loss at 3 days after induction than in controls
• chondrocyte cell death on both patellar and femoral surfaces increase 6X at 3 days and 12X at 7 days after induction
• considerable erosion of cartilage surfaces at both 3 and 7 days

immune system
increased susceptibility to induced arthritis ( J:106191 )
• increased knee joint inflammation 3 days after arthritis induction using immune complexes
• 300% more infiltrating cells than in controls
• inflammation persists without improvement for 7 days
• more proteoglycan loss at 3 days after induction than in controls
• chondrocyte cell death on both patellar and femoral surfaces increase 6X at 3 days and 12X at 7 days after induction
• considerable erosion of cartilage surfaces at both 3 and 7 days




Genotype
MGI:5462351
cn5
Allelic
Composition		 Fcgr2btm1Ttk/Fcgr2btm1Ttk
Traf3ip2tm2Sbn/Traf3ip2tm2Sbn
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background		 involves: 129S4/SvJae * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Fcgr2btm1Ttk mutation (7 available); any Fcgr2b mutation (49 available)
Traf3ip2tm2Sbn mutation (0 available); any Traf3ip2 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased germinal center B cell number ( J:191090 )
• mutants exhibit an increase in percentage and the total number of germinal center B cells compared to wild-type mice, although the total number of germinal center B cells is lower than in Fcgr2b homozygotes (that are also heterozygous for the floxed Traf3ip2 allele)
glomerulonephritis ( J:191090 )
• develop glomerulonephritis comparable to single Fcgr2b homozygotes

hematopoietic system
increased germinal center B cell number ( J:191090 )
• mutants exhibit an increase in percentage and the total number of germinal center B cells compared to wild-type mice, although the total number of germinal center B cells is lower than in Fcgr2b homozygotes (that are also heterozygous for the floxed Traf3ip2 allele)

renal/urinary system
glomerulonephritis ( J:191090 )
• develop glomerulonephritis comparable to single Fcgr2b homozygotes




Genotype
MGI:5427951
cx6
Allelic
Composition		 Fcgr2btm1Ttk/Fcgr2btm1Ttk
Sle21129P2/Ola/Sle21129P2/Ola
Genetic
Background		 B6.129S4-Fcgr2btm1Ttk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2btm1Ttk mutation (7 available); any Fcgr2b mutation (49 available)
Sle21129P2/Ola mutation (0 available); any Sle21 mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:179175 )
• at 8 and 12 months, mice develop fatal glomerular damage unlike wild-type mice

immune system
enlarged spleen ( J:179175 )
• spontaneously
increased spleen weight ( J:179175 )
• spontaneously
abnormal adaptive immunity ( J:179175 )
• mice exhibit increased antibody response after immunization, in mast cell-mediated cutaneous anaphylaxis, and in phagocytosis of immune complex (IC) by macrophages compared with control mice
increased immunoglobulin level ( J:179175 )
• kidney IgG and C3 depositions in a nephrotoxic nephritis model
increased IgG2a level ( J:179175 )
• in a nephrotoxic nephritis model that is more severe than in Fcgr2btm1.2Sjv homozygotes
increased susceptibility to induced arthritis ( J:179175 )
• collagen or K/BXN serum-induced that is more severe than in Fcgr2btm1.2Sjv homozygotes
increased autoantibody level ( J:179175 )
• spontaneous increase in Coombs, chromatin, double-strand DNA, single-strand DNA and histone autoantibodies
kidney inflammation ( J:179175 )
• in a nephrotoxic nephritis model that is more severe than in Fcgr2btm1.2Sjv homozygotes

renal/urinary system
albuminuria ( J:179175 )
• in a nephrotoxic nephritis model
kidney inflammation ( J:179175 )
• in a nephrotoxic nephritis model that is more severe than in Fcgr2btm1.2Sjv homozygotes
abnormal renal glomerulus morphology ( J:179175 )
• at 8 and 12 months, mice develop fatal glomerular damage unlike wild-type mice

homeostasis/metabolism
abnormal glomerular capillary thrombosis ( J:179175 )
• in a nephrotoxic nephritis model
albuminuria ( J:179175 )
• in a nephrotoxic nephritis model

skeleton
increased susceptibility to induced arthritis ( J:179175 )
• collagen or K/BXN serum-induced that is more severe than in Fcgr2btm1.2Sjv homozygotes

hematopoietic system
enlarged spleen ( J:179175 )
• spontaneously
increased spleen weight ( J:179175 )
• spontaneously
increased immunoglobulin level ( J:179175 )
• kidney IgG and C3 depositions in a nephrotoxic nephritis model
increased IgG2a level ( J:179175 )
• in a nephrotoxic nephritis model that is more severe than in Fcgr2btm1.2Sjv homozygotes

growth/size/body
enlarged spleen ( J:179175 )
• spontaneously
increased spleen weight ( J:179175 )
• spontaneously




Genotype
MGI:3851204
cx7
Allelic
Composition		 Fcer1atm1Knt/Fcer1atm1Knt
Fcer2atm1Max/Fcer2atm1Max
Fcgr1tm1Jsv/Fcgr1tm1Jsv
Fcgr2btm1Ttk/Fcgr2btm1Ttk
Fcgr3tm1Jsv/Fcgr3tm1Jsv
Genetic
Background		 B6.Cg-Fcgr2btm1Ttk Fcgr3tm1Jsv Fcer1atm1Knt Fcgr1tm1Jsv Fcer2atm1Max
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcer1atm1Knt mutation (3 available); any Fcer1a mutation (23 available)
Fcer2atm1Max mutation (0 available); any Fcer2a mutation (24 available)
Fcgr1tm1Jsv mutation (4 available); any Fcgr1 mutation (35 available)
Fcgr2btm1Ttk mutation (7 available); any Fcgr2b mutation (49 available)
Fcgr3tm1Jsv mutation (5 available); any Fcgr3 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal mast cell physiology ( J:144620 )
• mast cells fail to react and initiate an airway inflammatory response when IgE immune complexes are administered intranasally
• mice are able to react to IgE complexes one day after administration of supernatants collected from activated mast cells
abnormal macrophage physiology ( J:144620 )
• macrophages fail to react to IgE complexes
increased susceptibility to type I hypersensitivity reaction ( J:144620 )
• mice fail to initiate an airway inflammatory response when IgE immune complexes are administered intranasally

hematopoietic system
abnormal mast cell physiology ( J:144620 )
• mast cells fail to react and initiate an airway inflammatory response when IgE immune complexes are administered intranasally
• mice are able to react to IgE complexes one day after administration of supernatants collected from activated mast cells
abnormal macrophage physiology ( J:144620 )
• macrophages fail to react to IgE complexes




Genotype
MGI:5488508
cx8
Allelic
Composition		 Fcgr2btm1Ttk/Fcgr2btm1Ttk
Tlr7tm1Flv/Y
X/Yaa
Genetic
Background		 B6.Cg-Fcgr2btm1Ttk Tlr7tm1Flv Yaa
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2btm1Ttk mutation (7 available); any Fcgr2b mutation (49 available)
Tlr7tm1Flv mutation (1 available); any Tlr7 mutation (20 available)
Yaa mutation (24 available); any Yaa mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:127600 )
• survival is prolonged compared to mutant mice wild-type for Tlr7

immune system
enlarged spleen ( J:127600 )
• less severe at 5 months of age compared to mutant mice wild-type for Tlr7
abnormal splenocyte physiology ( J:127600 )
• activation of splenocytes is reduced compared to mutant mice wild-type for Tlr7
autoimmune response ( J:127600 )
• autoantibodies show a homogeneous nuclear pattern
increased susceptibility to systemic lupus erythematosus ( J:127600 )
• develop a lupus like syndrome at a later age and in lower numbers compared to mutant mice wild-type for Tlr7
increased anti-nuclear antigen antibody level ( J:127600 )
• increase in anti-RNA IgG levels in the serum at 4 - 6 months of age is less severe than in mutant mice wild-type for Tlr7 and is similar to mice homozygous for Fcgr2btm1Ttk alone

renal/urinary system
abnormal kidney morphology ( J:127600 )
• kidney disease is less severe at 5 months of age compared to mutant mice wild-type for Tlr7

hematopoietic system
enlarged spleen ( J:127600 )
• less severe at 5 months of age compared to mutant mice wild-type for Tlr7
abnormal splenocyte physiology ( J:127600 )
• activation of splenocytes is reduced compared to mutant mice wild-type for Tlr7

growth/size/body
enlarged spleen ( J:127600 )
• less severe at 5 months of age compared to mutant mice wild-type for Tlr7




Genotype
MGI:5488509
cx9
Allelic
Composition		 Fcgr2btm1Ttk/Fcgr2btm1Ttk
X/Yaa
Genetic
Background		 B6.Cg-Fcgr2btm1Ttk Yaa
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2btm1Ttk mutation (7 available); any Fcgr2b mutation (49 available)
Yaa mutation (24 available); any Yaa mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:127600 )
• moribund at 5 months of age

immune system
autoimmune response ( J:127600 )
• autoantibodies show a nucleolar pattern
increased anti-nuclear antigen antibody level ( J:127600 )
• marked increase in anti-RNA IgG levels in the serum at 4 - 6 months of age

renal/urinary system
abnormal kidney morphology ( J:127600 )
• kidney disease

hematopoietic system

growth/size/body
enlarged spleen ( J:127600 )




Genotype
MGI:5462346
cx10
Allelic
Composition		 Fcgr2btm1Ttk/Fcgr2btm1Ttk
Traf3ip2tm1Sbn/Traf3ip2tm1Sbn
Genetic
Background		 involves: 129 * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2btm1Ttk mutation (7 available); any Fcgr2b mutation (49 available)
Traf3ip2tm1Sbn mutation (0 available); any Traf3ip2 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:191090 )
• 75% of mutants survive to 12 months of age; this is an 89.7% improvement in survival rate when compared to Fcgr2b nulls heterozygous for Traf3ip2
premature death ( J:191090 )
• 75% of mutants survive to 12 months of age, indicating that 25% die before that time

immune system
abnormal T cell morphology ( J:191090 )
• expansion of IFN-gamma producing cells, mainly T cells, in spleens
increased double-negative T cell number ( J:191090 )
• increase in the numbers of double negative T-cells in the lymph nodes
increased IgG level ( J:191090 )
• total serum IgG is increased and IgG deposition in the kidneys
decreased susceptibility to systemic lupus erythematosus ( J:191090 )
• mutants exhibit a reversal of spontaneous germinal center formation, the expansion of plasma cell numbers, and the increased numbers of T effector-memory cells that are seen in Fcgr2b nulls heterozygous for Traf3ip2
• mutants exhibit reduced infiltration of inflammatory cells into kidneys and glomerular pathology is greatly reduced compared to Fcgr2b nulls heterozygous for Traf3ip2
• mutants do not exhibit an increase in CD11b+CD11c- monocytic cells, CD11b+CD11c+ myeloid DCs and CD11c+B220+ plasmacytoid DCs in spleens as seen in Fcgr2b nulls heterozygous for Traf3ip2
increased autoantibody level ( J:191090 )
• presence of anti-nRNP (ribonucleoprotein) antibodies
increased anti-double stranded DNA antibody level ( J:191090 )
• presence of double-stranded DNA IgG antibodies

hematopoietic system
abnormal T cell morphology ( J:191090 )
• expansion of IFN-gamma producing cells, mainly T cells, in spleens
increased double-negative T cell number ( J:191090 )
• increase in the numbers of double negative T-cells in the lymph nodes
increased IgG level ( J:191090 )
• total serum IgG is increased and IgG deposition in the kidneys




Genotype
MGI:5462253
cx11
Allelic
Composition		 Fcgr2btm1Ttk/Fcgr2btm1Ttk
Traf3ip2tm1Sbn/Traf3ip2+
Genetic
Background		 involves: 129 * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2btm1Ttk mutation (7 available); any Fcgr2b mutation (49 available)
Traf3ip2tm1Sbn mutation (0 available); any Traf3ip2 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:191090 )
• only 7.7% of mutants are still alive at 12 months of age
premature death ( J:191090 )
• only 7.7% of mutants are still alive at 12 months of age

renal/urinary system
kidney inflammation ( J:191090 )
• infiltrating neutrophils and monocytic cells in the kidney, extending into interstitial regions

immune system
abnormal neutrophil morphology ( J:191090 )
• neutrophil extracellular traps are seen in the kidneys
increased neutrophil cell number ( J:191090 )
• increase in numbers of neutrophils and monocytic cells in perfused kidneys
increased myeloid dendritic cell number ( J:191090 )
• increase in CD11b+CD11c+ myeloid dendritic cells in spleens
increased plasmacytoid dendritic cell number ( J:191090 )
• increase in CD11c+B220+ plasmacytoid dendritic cells in spleens
increased monocyte cell number ( J:191090 )
• increase in CD11b+CD11c- monocytic cells in spleens
• increase in numbers of monocytic cells in perfused kidneys
abnormal T cell morphology ( J:191090 )
• expansion of IFN-gamma producing cells, mainly T cells, in spleens
increased double-negative T cell number ( J:191090 )
• increase in numbers of double negative T cells in the kidneys
increased memory T cell number ( J:191090 )
• increase in numbers of T effector-memory cells (CD4+CD62L-CD44+)
increased single-positive T cell number ( J:191090 )
• increase in numbers of CD4+ T cells, and to a lesser degree, CD8+ T cells, in the kidneys
increased spleen germinal center number ( J:191090 )
• form spontaneous germinal centers
increased IgG level ( J:191090 )
• total serum IgG is increased and IgG deposition in the kidneys
increased autoantibody level ( J:191090 )
• presence of anti-nRNP (ribonucleoprotein) antibodies
increased anti-double stranded DNA antibody level ( J:191090 )
• presence of double-stranded DNA IgG antibodies
kidney inflammation ( J:191090 )
• infiltrating neutrophils and monocytic cells in the kidney, extending into interstitial regions

hematopoietic system
abnormal neutrophil morphology ( J:191090 )
• neutrophil extracellular traps are seen in the kidneys
increased neutrophil cell number ( J:191090 )
• increase in numbers of neutrophils and monocytic cells in perfused kidneys
increased myeloid dendritic cell number ( J:191090 )
• increase in CD11b+CD11c+ myeloid dendritic cells in spleens
increased plasmacytoid dendritic cell number ( J:191090 )
• increase in CD11c+B220+ plasmacytoid dendritic cells in spleens
increased monocyte cell number ( J:191090 )
• increase in CD11b+CD11c- monocytic cells in spleens
• increase in numbers of monocytic cells in perfused kidneys
abnormal T cell morphology ( J:191090 )
• expansion of IFN-gamma producing cells, mainly T cells, in spleens
increased double-negative T cell number ( J:191090 )
• increase in numbers of double negative T cells in the kidneys
increased memory T cell number ( J:191090 )
• increase in numbers of T effector-memory cells (CD4+CD62L-CD44+)
increased single-positive T cell number ( J:191090 )
• increase in numbers of CD4+ T cells, and to a lesser degree, CD8+ T cells, in the kidneys
increased spleen germinal center number ( J:191090 )
• form spontaneous germinal centers
increased IgG level ( J:191090 )
• total serum IgG is increased and IgG deposition in the kidneys




Genotype
MGI:5427953
cx12
Allelic
Composition		 Fcgr2btm1Ttk/Fcgr2btm1.2Jsv
Sle21129P2/Ola/Sle21C57BL/6
Genetic
Background		 involves: 129P2/Ola * 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2btm1.2Jsv mutation (1 available); any Fcgr2b mutation (49 available)
Fcgr2btm1Ttk mutation (7 available); any Fcgr2b mutation (49 available)
Sle21129P2/Ola mutation (0 available); any Sle21 mutation (0 available)
Sle21C57BL/6 mutation (0 available); any Sle21 mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:179175 )
• mice exhibit greater cumulative death compared with wild-type C57BL/6 mice

immune system
enlarged spleen ( J:179175 )
• not as severe as in Fcgr2btm1Ttk homozygotes
increased spleen weight ( J:179175 )
• not as severe as in Fcgr2btm1Ttk homozygotes
increased anti-chromatin antibody level ( J:179175 )
• not as severe as in Fcgr2btm1Ttk homozygotes
increased anti-histone antibody level ( J:179175 )
• not as severe as in Fcgr2btm1Ttk homozygotes

renal/urinary system
albuminuria ( J:179175 )
• not as severe as in Fcgr2btm1Ttk homozygotes
abnormal kidney morphology ( J:179175 )
• kidney pathology is increased compared to in wild-type C57BL/6 mice

homeostasis/metabolism
albuminuria ( J:179175 )
• not as severe as in Fcgr2btm1Ttk homozygotes

hematopoietic system
enlarged spleen ( J:179175 )
• not as severe as in Fcgr2btm1Ttk homozygotes
increased spleen weight ( J:179175 )
• not as severe as in Fcgr2btm1Ttk homozygotes

growth/size/body
enlarged spleen ( J:179175 )
• not as severe as in Fcgr2btm1Ttk homozygotes
increased spleen weight ( J:179175 )
• not as severe as in Fcgr2btm1Ttk homozygotes




Genotype
MGI:2664970
cx13
Allelic
Composition		 Fcgr1tm1Jsv/Fcgr1tm1Jsv
Fcgr2btm1Ttk/Fcgr2btm1Ttk
Fcgr3tm1Jsv/Fcgr3tm1Jsv
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr1tm1Jsv mutation (4 available); any Fcgr1 mutation (35 available)
Fcgr2btm1Ttk mutation (7 available); any Fcgr2b mutation (49 available)
Fcgr3tm1Jsv mutation (5 available); any Fcgr3 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired macrophage phagocytosis ( J:83995 )
• phagocytosis of all IgG-IC by macrophages is abrogated

hematopoietic system
impaired macrophage phagocytosis ( J:83995 )
• phagocytosis of all IgG-IC by macrophages is abrogated

cellular
impaired macrophage phagocytosis ( J:83995 )
• phagocytosis of all IgG-IC by macrophages is abrogated




Genotype
MGI:5462357
cx14
Allelic
Composition		 Fcgr2btm1Ttk/Fcgr2btm1Ttk
Il17atm1Yiw/Il17a+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2btm1Ttk mutation (7 available); any Fcgr2b mutation (49 available)
Il17atm1Yiw mutation (0 available); any Il17a mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:191090 )
• about 35.7% of mutants are alive after 12 months of age
premature death ( J:191090 )
• about 35.7% of mutants are alive after 12 months of age

immune system
increased spleen germinal center number ( J:191090 )
• develop spontaneous germinal centers
kidney inflammation ( J:191090 )
• infiltrating neutrophils and monocytic cells in the kidney, extending into interstitial regions

hematopoietic system
increased spleen germinal center number ( J:191090 )
• develop spontaneous germinal centers

renal/urinary system
kidney inflammation ( J:191090 )
• infiltrating neutrophils and monocytic cells in the kidney, extending into interstitial regions




Genotype
MGI:5462360
cx15
Allelic
Composition		 Fcgr2btm1Ttk/Fcgr2btm1Ttk
Il17atm1Yiw/Il17atm1Yiw
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2btm1Ttk mutation (7 available); any Fcgr2b mutation (49 available)
Il17atm1Yiw mutation (0 available); any Il17a mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:191090 )
• 91.7% of mutants are alive after 12 months of age; this is a 61.1% improvement of survival rates compared to Fcgr2b nulls heterozygous for Il17a
premature death ( J:191090 )
• 91.7% of mutants are alive after 12 months of age, indicating some loss before one year of age

immune system
increased double-negative T cell number ( J:191090 )
• increase in numbers of double negative T cells in the kidneys
increased spleen germinal center number ( J:191090 )
• develop spontaneous germinal centers (to a similar level that is seen in Fcgr2b nulls heterozygous for Il17a)
decreased susceptibility to systemic lupus erythematosus ( J:191090 )
• mutants are much less susceptible to lupus pathology compared to single Fcgr2b homozygotes or Fcgr2b nulls heterozygous for Il17a
• mutants exhibit reduced inflammatory cell infiltration and glomerulonephritis in kidneys compared to Fcgr2b nulls heterozygous for Il17a

hematopoietic system
increased double-negative T cell number ( J:191090 )
• increase in numbers of double negative T cells in the kidneys
increased spleen germinal center number ( J:191090 )
• develop spontaneous germinal centers (to a similar level that is seen in Fcgr2b nulls heterozygous for Il17a)




Genotype
MGI:5574062
cx16
Allelic
Composition		 Fcgr2btm1Ttk/Fcgr2btm1Ttk
Pdcd1tm1Hon/Pdcd1tm1Hon
Genetic
Background		 involves: 129S2/SvPas * 129S4/SvJae * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2btm1Ttk mutation (7 available); any Fcgr2b mutation (49 available)
Pdcd1tm1Hon mutation (6 available); any Pdcd1 mutation (97 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal cytokine level ( J:207275 )
• inflammatory cytokines, including Il2ra, Tnf, Icos, Il1b, Socs1, and Vcam1, are expressed in the suburothelial layer of mice that have anti-urothelial antibodies
abnormal urine cytokine level ( J:207275 )
• urinary cytokines, including GM-CSF, TNF-alpha, IL1-alpha, G-CSF, and IL-1beta, are upregulated in the urine of mice that have anti-urothelial antibodies
increased autoantibody level ( J:207275 )
• anti-urothelial autoantibodies are seen in the serum as early as 7 weeks of age, with about 50% of mice showing autoantibodies at 10 weeks of age
urinary bladder inflammation ( J:207275 )
• mice that are positive for anti-urothelial antibodies show massive infiltration of inflammatory cells at the suburothelial layer

renal/urinary system
abnormal urine cytokine level ( J:207275 )
• urinary cytokines, including GM-CSF, TNF-alpha, IL1-alpha, G-CSF, and IL-1beta, are upregulated in the urine of mice that have anti-urothelial antibodies
urinary bladder inflammation ( J:207275 )
• mice that are positive for anti-urothelial antibodies show massive infiltration of inflammatory cells at the suburothelial layer
abnormal urinary bladder urothelium morphology ( J:207275 )
• mice that are positive for anti-urothelial antibodies show disarrangement of urothelial plaque on the surface of the bladder and disarranged cellular structure of the bladder epithelium at 16 weeks of age
• surface of bladder epithelium shows poorer plaque formation, exposing bare surface of smaller epithelial cells beneath it, in mice that are positive for anti-urothelial antibodies
oliguria ( J:207275 )
• mice that are positive for anti-urothelial antibodies void less urine per void than wild-type mice, even when corrected for body weight

homeostasis/metabolism
abnormal cytokine level ( J:207275 )
• inflammatory cytokines, including Il2ra, Tnf, Icos, Il1b, Socs1, and Vcam1, are expressed in the suburothelial layer of mice that have anti-urothelial antibodies
abnormal urine cytokine level ( J:207275 )
• urinary cytokines, including GM-CSF, TNF-alpha, IL1-alpha, G-CSF, and IL-1beta, are upregulated in the urine of mice that have anti-urothelial antibodies

growth/size/body
decreased body weight ( J:207275 )
• lower body weight in mice that are positive for anti-urothelial antibodies

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
cystitis DOID:1679 J:207275




Genotype
MGI:5462356
cx17
Allelic
Composition		 Fcgr2btm1Ttk/Fcgr2btm1Ttk
Traf3ip2tm2Sbn/Traf3ip2+
Genetic
Background		 involves: 129S4/SvJae * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2btm1Ttk mutation (7 available); any Fcgr2b mutation (49 available)
Traf3ip2tm2Sbn mutation (0 available); any Traf3ip2 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased germinal center B cell number ( J:191090 )
• increase in the total number of germinal center B cells
increased plasma cell number ( J:191090 )
• increase in the percentage and number of plasma cells

immune system
increased germinal center B cell number ( J:191090 )
• increase in the total number of germinal center B cells
increased plasma cell number ( J:191090 )
• increase in the percentage and number of plasma cells

growth/size/body
enlarged spleen ( J:191090 )
increased spleen weight ( J:191090 )
spleen hyperplasia ( J:191090 )




Genotype
MGI:3784429
cx18
Allelic
Composition		 Fcgr2btm1Ttk/Fcgr2btm1Ttk
Tg(Ins2-TFRC/OVA)296Wehi/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2btm1Ttk mutation (7 available); any Fcgr2b mutation (49 available)
Tg(Ins2-TFRC/OVA)296Wehi mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to autoimmune diabetes ( J:122114 )
• mice treated with Tg(TcraTcrb)1100Mjb CD8+ T cells from a Rag1 null mouse and anti-ovalbumin IgG at 10-fold lower doses than in Tg(Ins2-TFRC/OVA)296Wehi mice develop diabetes




Genotype
MGI:4360218
cx19
Allelic
Composition		 Fcgr2btm1Ttk/Fcgr2b+
X/Yaa
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * SB/Le
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2btm1Ttk mutation (7 available); any Fcgr2b mutation (49 available)
Yaa mutation (24 available); any Yaa mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased monocyte cell number ( J:129409 )
• 58% of mice display monocytosis by 10 months of age with a Gr-1- subset predominating

hematopoietic system
increased monocyte cell number ( J:129409 )
• 58% of mice display monocytosis by 10 months of age with a Gr-1- subset predominating




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory