All Phenotypes Kdr<tm1Jrt> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Kdr^tm1Jrt
targeted mutation 1, Janet Rossant
MGI:1857168

Summary

15 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kdr^tm1Jrt/Kdr^tm1Jrt	B6.129-Kdr^tm1Jrt/J	MGI:3531326
hm2	Kdr^tm1Jrt/Kdr^tm1Jrt	involves: 129S1/Sv * 129X1/SvJ	MGI:2167318
hm3	Kdr^tm1Jrt/Kdr^tm1Jrt	Not Specified	MGI:3527544
ht4	Kdr^tm1Jrt/Kdr⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:2167319
ht5	Kdr^tm1Jrt/Kdr^tm1.1Msh	involves: 129P2/OlaHsd * B6.129-Kdr^tm1Jrt/J * C57BL/6J	MGI:3531324
cn6	Kdr^tm1Jrt/Kdr⁺ Pten^tm1Hwu/Pten^tm1Hwu Twist2^{tm1.1(cre)Dor}/Twist2⁺	B6.129-Twist2^{tm1.1(cre)Dor} Kdr^tm1Jrt Pten^tm1Hwu	MGI:5503216
cn7	Flt1^tm1.1Fong/Flt1^tm1.1Fong Kdr^tm1Jrt/Kdr⁺ Gt(ROSA)26Sor^{tm1(cre/ERT2)Thl}/Gt(ROSA)26Sor⁺	involves: 129 * C57BL/6NCr * CD-1	MGI:5523778
cn8	Kdr^tm1Jrt/Kdr^tm2Sato Tg(Nes-cre)1Wmz/0	involves: 129S1/Sv * 129X1/SvJ	MGI:5432161
cn9	Kdr^tm1Jrt/Kdr^tm1.1Jamb Tg(CAG-cre/Esr1*)1Egwa/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	MGI:5052372
cx10	Kdr^tm1Jrt/Kdr⁺ Prdm1^tm2Rob/Prdm1^tm2Rob	involves: 129	MGI:5439606
cx11	Kdr^tm1Jrt/Kdr⁺ Tmem204^tm1.1Ali/Tmem204^tm1.1Ali	involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6	MGI:4454673
cx12	Kdr^tm1Jrt/Kdr⁺ Rasip1^tm1.1Oncl/Rasip1^tm1.1Oncl	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:5056105
cx13	Kdr^tm1Jrt/Kdr⁺ Tg(tetO-Kdr*)4377.5Rwng/0 Tg(Cebpb-tTA)5Bjd/0	involves: 129S1/Sv * 129X1/SvJ * FVB/N * NMRI	MGI:3810713
cx14	Flt1^tm2Msh/Flt1^tm2Msh Kdr^tm1Jrt/Kdr^tm1Jrt	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3527543
cx15	Flt1^tm2Msh/Flt1^tm2Msh Kdr^tm1Jrt/Kdr⁺	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3527542

Allelic Composition	Kdr^tm1Jrt/Kdr^tm1Jrt
Genetic Background	B6.129-Kdr^tm1Jrt/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdr^tm1Jrt mutation (1 available); any Kdr mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal dorsal aorta morphology ( J:96124 )

• at E8.5, dorsal aorta is absent

absent organized vascular network ( J:96124 )

• at E8.5 vessels in the head as well as the dorsal aorta and vitelline artery are absent

• at E9.5 no blood vessels are seen

absent vitelline blood vessels ( J:96124 )

• at E9.5

embryo

absent vitelline blood vessels ( J:96124 )

• at E9.5

absent visceral yolk sac blood islands ( J:96124 )

• at E7.5

abnormal extraembryonic mesoderm development ( J:96124 )

• at E7.5 the extraembryonic mesoderm consists of only a single cell layer

hematopoietic system

impaired hematopoiesis ( J:96124 )

• the number of hematopoietic progenitors and the number of erythoid, granulocyte/macrophage and mixed colonies formed are severely reduced

Allelic Composition	Kdr^tm1Jrt/Kdr^tm1Jrt
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdr^tm1Jrt mutation (1 available); any Kdr mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:26846 )

• no embryos are recovered at E10.5 but are present at E9.5

embryo

absent vitelline blood vessels ( J:26846 )

• at E8.5, yolk sac lack blood vessels and consist of a single layer of mesothelium lining the yolk sac endothelium

decreased embryo size ( J:26846 )

• at E9.5

abnormal embryonic tissue morphology ( J:26846 )

embryo tissue necrosis ( J:26846 )

• embryos exhibit necrosis likely from cardiac failure

abnormal allantois morphology ( J:125783 )

• allantois explants fail to form any endothelial structures

absent visceral yolk sac blood islands ( J:26846 )

cardiovascular system

absent organized vascular network ( J:26846 )

absent vitelline blood vessels ( J:26846 )

• at E8.5, yolk sac lack blood vessels and consist of a single layer of mesothelium lining the yolk sac endothelium

congestive heart failure ( J:26846 )

• embryos exhibit necrosis likely from cardiac failure

hematopoietic system

abnormal definitive hematopoiesis ( J:26846 )

• expression of markers for hematopiesis could not be detected at E8.5

• at E8.5 only very rare committed hematopoietic cells could be identified by methylcellulose colony assay

growth/size/body

decreased embryo size ( J:26846 )

• at E9.5

Allelic Composition	Kdr^tm1Jrt/Kdr^tm1Jrt
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdr^tm1Jrt mutation (1 available); any Kdr mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

absent organized vascular network ( J:95387 )

• Kdr+ cells (lacZ expressing) reach the anterior portion portion of the embryo but no blood vessels develop

Allelic Composition	Kdr^tm1Jrt/Kdr⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdr^tm1Jrt mutation (1 available); any Kdr mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:26846 )

Allelic Composition	Kdr^tm1Jrt/Kdr^tm1.1Msh
Genetic Background	involves: 129P2/OlaHsd * B6.129-Kdr^tm1Jrt/J * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdr^tm1.1Msh mutation (1 available); any Kdr mutation (74 available)
Kdr^tm1Jrt mutation (1 available); any Kdr mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal dorsal aorta morphology ( J:96124 )

• at E8.5, dorsal aorta is absent

absent organized vascular network ( J:96124 )

• at E8.5 vessels in the head as well as the dorsal aorta and vitelline artery are absent

embryo

absent visceral yolk sac blood islands ( J:96124 )

• at E7.5

abnormal extraembryonic mesoderm development ( J:96124 )

• at E7.5 the extraembryonic mesoderm consists of only a single cell layer

Allelic Composition	Kdr^tm1Jrt/Kdr⁺ Pten^tm1Hwu/Pten^tm1Hwu Twist2^{tm1.1(cre)Dor}/Twist2⁺
Genetic Background	B6.129-Twist2^{tm1.1(cre)Dor} Kdr^tm1Jrt Pten^tm1Hwu

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdr^tm1Jrt mutation (1 available); any Kdr mutation (74 available)
Pten^tm1Hwu mutation (16 available); any Pten mutation (88 available)
Twist2^{tm1.1(cre)Dor} mutation (1 available); any Twist2 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Defect in angioblast differentiation in Pten^tm1Hwu/Pten^tm1Hwu Kdr^tm1Jrt/Kdr⁺ Twist2^{tm1.1(cre)Dor}/Twist2⁺ mice

cardiovascular system

abnormal vasculogenesis ( J:192736 )

• vasculogenesis defect

• impaired differentiation of angioblasts into mature endothelial cells and blood vessels

respiratory system

abnormal lung morphology ( J:192736 )

• increase in angioblasts in E18.5 lungs

Allelic Composition	Flt1^tm1.1Fong/Flt1^tm1.1Fong Kdr^tm1Jrt/Kdr⁺ Gt(ROSA)26Sor^{tm1(cre/ERT2)Thl}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129 * C57BL/6NCr * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt1^tm1.1Fong mutation (1 available); any Flt1 mutation (76 available)
Gt(ROSA)26Sor^{tm1(cre/ERT2)Thl} mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Kdr^tm1Jrt mutation (1 available); any Kdr mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

increased angiogenesis ( J:202202 )

• in the brain and liver of tamoxifen treated mice compared with control mice but not as severe as in mice also lacking the Kdr null allele

• some small focal areas in the retina in tamoxifen-treated mice relative to mice lacking the Kdr null allele

• however, angiogenesis in the heart is normal

Allelic Composition	Kdr^tm1Jrt/Kdr^tm2Sato Tg(Nes-cre)1Wmz/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdr^tm1Jrt mutation (1 available); any Kdr mutation (74 available)
Kdr^tm2Sato mutation (1 available); any Kdr mutation (74 available)
Tg(Nes-cre)1Wmz mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:175836 )

N	• normal numbers of gonadotropin-releasing hormone neurons

Allelic Composition	Kdr^tm1Jrt/Kdr^tm1.1Jamb Tg(CAG-cre/Esr1*)1Egwa/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdr^tm1.1Jamb mutation (0 available); any Kdr mutation (74 available)
Kdr^tm1Jrt mutation (1 available); any Kdr mutation (74 available)
Tg(CAG-cre/Esr1*)1Egwa mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Suppression of of extraretinal vascular outgrowth in ischemic Kdr^tm1.1Jamb/Kdr^tm1Jrt Tg(CAG-cre/Esr1*)1Egwa/0 retinas

cardiovascular system

abnormal induced retina neovascularization ( J:173943 )

• tamoxifen-treated mice exhibit decreased extraretinal vascular outgrowth in ischemic retinas compared with control mice

vision/eye

abnormal induced retina neovascularization ( J:173943 )

• tamoxifen-treated mice exhibit decreased extraretinal vascular outgrowth in ischemic retinas compared with control mice

Allelic Composition	Kdr^tm1Jrt/Kdr⁺ Prdm1^tm2Rob/Prdm1^tm2Rob
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdr^tm1Jrt mutation (1 available); any Kdr mutation (74 available)
Prdm1^tm2Rob mutation (0 available); any Prdm1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal placental labyrinth vasculature morphology ( J:187742 )

• fetal capillaries fail to extend into the labyrinth tissue and instead are largely restricted to the base of the labyrinth

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:187742 )

• fetal capillaries fail to extend into the labyrinth tissue and instead are largely restricted to the base of the labyrinth

Allelic Composition	Kdr^tm1Jrt/Kdr⁺ Tmem204^tm1.1Ali/Tmem204^tm1.1Ali
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdr^tm1Jrt mutation (1 available); any Kdr mutation (74 available)
Tmem204^tm1.1Ali mutation (0 available); any Tmem204 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal lymphatic vessel smooth muscle morphology ( J:159519 )

• abnormal smooth muscle cell coating

enlarged lymphatic vessel ( J:159519 )

• enlarged lymphatic vessels are even more dilated than in Tmem204^tm1.1Ali single knock-outs

muscle

abnormal lymphatic vessel smooth muscle morphology ( J:159519 )

• abnormal smooth muscle cell coating

Allelic Composition	Kdr^tm1Jrt/Kdr⁺ Rasip1^tm1.1Oncl/Rasip1^tm1.1Oncl
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdr^tm1Jrt mutation (1 available); any Kdr mutation (74 available)
Rasip1^tm1.1Oncl mutation (0 available); any Rasip1 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal vasculogenesis ( J:174152 )

• at E9.5, mice fail to exhibit remodeling of the initial plexus in embryonic tissue unlike wild-type mice

embryo

abnormal vitelline vascular remodeling ( J:174152 )

• at E9.5, mice fail to exhibit remodeling of the initial plexus in the yolk sac unlike wild-type mice

Allelic Composition	Kdr^tm1Jrt/Kdr⁺ Tg(tetO-Kdr*)4377.5Rwng/0 Tg(Cebpb-tTA)5Bjd/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * FVB/N * NMRI

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdr^tm1Jrt mutation (1 available); any Kdr mutation (74 available)
Tg(Cebpb-tTA)5Bjd mutation (3 available)
Tg(tetO-Kdr*)4377.5Rwng mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

abnormal liver development ( J:100427 )

• at E12.5, liver vasculature is less organized and vessels are dilated

• at E13.5, microvascular network is more disorganized with fewer branches than in control livers; newborns have very little microvascular network is observed

Allelic Composition	Flt1^tm2Msh/Flt1^tm2Msh Kdr^tm1Jrt/Kdr^tm1Jrt
Genetic Background	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt1^tm2Msh mutation (1 available); any Flt1 mutation (76 available)
Kdr^tm1Jrt mutation (1 available); any Kdr mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality ( J:95387 )

• all of the double homozygotes die as embryos

cardiovascular system

abnormal vascular endothelial cell migration ( J:95387 )

• Kdr+ cells (lacZ expressing) abnormally accumulate in the posterior portion of the embryo

cellular

abnormal vascular endothelial cell migration ( J:95387 )

• Kdr+ cells (lacZ expressing) abnormally accumulate in the posterior portion of the embryo

Allelic Composition	Flt1^tm2Msh/Flt1^tm2Msh Kdr^tm1Jrt/Kdr⁺
Genetic Background	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:95387 )

• about 90% of mutants die as embryos

cardiovascular system

abnormal vascular endothelial cell differentiation ( J:95387 )

• differentiation of vascular endothelial cells is disturbed

abnormal vascular endothelial cell migration ( J:95387 )

• Kdr+ cells (lacZ expressing) abnormally accumulate in the middle to posterior portion of the embryo

cellular

abnormal vascular endothelial cell differentiation ( J:95387 )

• differentiation of vascular endothelial cells is disturbed

abnormal vascular endothelial cell migration ( J:95387 )

• Kdr+ cells (lacZ expressing) abnormally accumulate in the middle to posterior portion of the embryo

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