All Phenotypes Kdr<tm1Jrt> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Kdr^tm1Jrt
targeted mutation 1, Janet Rossant
MGI:1857168

Summary

15 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kdr^tm1Jrt/Kdr^tm1Jrt	B6.129-Kdr^tm1Jrt/J	MGI:3531326
hm2	Kdr^tm1Jrt/Kdr^tm1Jrt	involves: 129S1/Sv * 129X1/SvJ	MGI:2167318
hm3	Kdr^tm1Jrt/Kdr^tm1Jrt	Not Specified	MGI:3527544
ht4	Kdr^tm1Jrt/Kdr⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:2167319
ht5	Kdr^tm1Jrt/Kdr^tm1.1Msh	involves: 129P2/OlaHsd * B6.129-Kdr^tm1Jrt/J * C57BL/6J	MGI:3531324
cn6	Kdr^tm1Jrt/Kdr⁺ Pten^tm1Hwu/Pten^tm1Hwu Twist2^{tm1.1(cre)Dor}/Twist2⁺	B6.129-Twist2^{tm1.1(cre)Dor} Kdr^tm1Jrt Pten^tm1Hwu	MGI:5503216
cn7	Flt1^tm1.1Fong/Flt1^tm1.1Fong Kdr^tm1Jrt/Kdr⁺ Gt(ROSA)26Sor^{tm1(cre/ERT2)Thl}/Gt(ROSA)26Sor⁺	involves: 129 * C57BL/6NCr * CD-1	MGI:5523778
cn8	Kdr^tm1Jrt/Kdr^tm2Sato Tg(Nes-cre)1Wmz/0	involves: 129S1/Sv * 129X1/SvJ	MGI:5432161
cn9	Kdr^tm1Jrt/Kdr^tm1.1Jamb Tg(CAG-cre/Esr1*)1Egwa/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	MGI:5052372
cx10	Kdr^tm1Jrt/Kdr⁺ Prdm1^tm2Rob/Prdm1^tm2Rob	involves: 129	MGI:5439606
cx11	Kdr^tm1Jrt/Kdr⁺ Tmem204^tm1.1Ali/Tmem204^tm1.1Ali	involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6	MGI:4454673
cx12	Kdr^tm1Jrt/Kdr⁺ Rasip1^tm1.1Oncl/Rasip1^tm1.1Oncl	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:5056105
cx13	Kdr^tm1Jrt/Kdr⁺ Tg(tetO-Kdr*)4377.5Rwng/0 Tg(Cebpb-tTA)5Bjd/0	involves: 129S1/Sv * 129X1/SvJ * FVB/N * NMRI	MGI:3810713
cx14	Flt1^tm2Msh/Flt1^tm2Msh Kdr^tm1Jrt/Kdr^tm1Jrt	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3527543
cx15	Flt1^tm2Msh/Flt1^tm2Msh Kdr^tm1Jrt/Kdr⁺	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3527542

Allelic Composition	Kdr^tm1Jrt/Kdr^tm1Jrt
Genetic Background	B6.129-Kdr^tm1Jrt/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdr^tm1Jrt mutation (1 available); any Kdr mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal dorsal aorta morphology ( J:96124 )

• at E8.5, dorsal aorta is absent

absent organized vascular network ( J:96124 )

• at E8.5 vessels in the head as well as the dorsal aorta and vitelline artery are absent

• at E9.5 no blood vessels are seen

absent vitelline blood vessels ( J:96124 )

• at E9.5

embryo

absent vitelline blood vessels ( J:96124 )

• at E9.5

absent visceral yolk sac blood islands ( J:96124 )

• at E7.5

abnormal extraembryonic mesoderm development ( J:96124 )

• at E7.5 the extraembryonic mesoderm consists of only a single cell layer

hematopoietic system

impaired hematopoiesis ( J:96124 )

• the number of hematopoietic progenitors and the number of erythoid, granulocyte/macrophage and mixed colonies formed are severely reduced

Allelic Composition	Kdr^tm1Jrt/Kdr^tm1Jrt
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdr^tm1Jrt mutation (1 available); any Kdr mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:26846 )

• no embryos are recovered at E10.5 but are present at E9.5

embryo

absent vitelline blood vessels ( J:26846 )

• at E8.5, yolk sac lack blood vessels and consist of a single layer of mesothelium lining the yolk sac endothelium

decreased embryo size ( J:26846 )

• at E9.5

abnormal embryonic tissue morphology ( J:26846 )

embryo tissue necrosis ( J:26846 )

• embryos exhibit necrosis likely from cardiac failure

abnormal allantois morphology ( J:125783 )

• allantois explants fail to form any endothelial structures

absent visceral yolk sac blood islands ( J:26846 )

cardiovascular system

absent organized vascular network ( J:26846 )

absent vitelline blood vessels ( J:26846 )

• at E8.5, yolk sac lack blood vessels and consist of a single layer of mesothelium lining the yolk sac endothelium

congestive heart failure ( J:26846 )

• embryos exhibit necrosis likely from cardiac failure

hematopoietic system

abnormal definitive hematopoiesis ( J:26846 )

• expression of markers for hematopiesis could not be detected at E8.5

• at E8.5 only very rare committed hematopoietic cells could be identified by methylcellulose colony assay

growth/size/body

decreased embryo size ( J:26846 )

• at E9.5

Allelic Composition	Kdr^tm1Jrt/Kdr^tm1Jrt
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdr^tm1Jrt mutation (1 available); any Kdr mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

absent organized vascular network ( J:95387 )

• Kdr+ cells (lacZ expressing) reach the anterior portion portion of the embryo but no blood vessels develop

Allelic Composition	Kdr^tm1Jrt/Kdr⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdr^tm1Jrt mutation (1 available); any Kdr mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:26846 )

Allelic Composition	Kdr^tm1Jrt/Kdr^tm1.1Msh
Genetic Background	involves: 129P2/OlaHsd * B6.129-Kdr^tm1Jrt/J * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdr^tm1.1Msh mutation (1 available); any Kdr mutation (74 available)
Kdr^tm1Jrt mutation (1 available); any Kdr mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal dorsal aorta morphology ( J:96124 )

• at E8.5, dorsal aorta is absent

absent organized vascular network ( J:96124 )

• at E8.5 vessels in the head as well as the dorsal aorta and vitelline artery are absent

embryo

absent visceral yolk sac blood islands ( J:96124 )

• at E7.5

abnormal extraembryonic mesoderm development ( J:96124 )

• at E7.5 the extraembryonic mesoderm consists of only a single cell layer

Allelic Composition	Kdr^tm1Jrt/Kdr⁺ Pten^tm1Hwu/Pten^tm1Hwu Twist2^{tm1.1(cre)Dor}/Twist2⁺
Genetic Background	B6.129-Twist2^{tm1.1(cre)Dor} Kdr^tm1Jrt Pten^tm1Hwu

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdr^tm1Jrt mutation (1 available); any Kdr mutation (74 available)
Pten^tm1Hwu mutation (16 available); any Pten mutation (88 available)
Twist2^{tm1.1(cre)Dor} mutation (1 available); any Twist2 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Defect in angioblast differentiation in Pten^tm1Hwu/Pten^tm1Hwu Kdr^tm1Jrt/Kdr⁺ Twist2^{tm1.1(cre)Dor}/Twist2⁺ mice

cardiovascular system

abnormal vasculogenesis ( J:192736 )

• vasculogenesis defect

• impaired differentiation of angioblasts into mature endothelial cells and blood vessels

respiratory system

abnormal lung morphology ( J:192736 )

• increase in angioblasts in E18.5 lungs

Allelic Composition	Flt1^tm1.1Fong/Flt1^tm1.1Fong Kdr^tm1Jrt/Kdr⁺ Gt(ROSA)26Sor^{tm1(cre/ERT2)Thl}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129 * C57BL/6NCr * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt1^tm1.1Fong mutation (1 available); any Flt1 mutation (76 available)
Gt(ROSA)26Sor^{tm1(cre/ERT2)Thl} mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Kdr^tm1Jrt mutation (1 available); any Kdr mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

increased angiogenesis ( J:202202 )

• in the brain and liver of tamoxifen treated mice compared with control mice but not as severe as in mice also lacking the Kdr null allele

• some small focal areas in the retina in tamoxifen-treated mice relative to mice lacking the Kdr null allele

• however, angiogenesis in the heart is normal

Allelic Composition	Kdr^tm1Jrt/Kdr^tm2Sato Tg(Nes-cre)1Wmz/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdr^tm1Jrt mutation (1 available); any Kdr mutation (74 available)
Kdr^tm2Sato mutation (1 available); any Kdr mutation (74 available)
Tg(Nes-cre)1Wmz mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:175836 )

N	• normal numbers of gonadotropin-releasing hormone neurons

Allelic Composition	Kdr^tm1Jrt/Kdr^tm1.1Jamb Tg(CAG-cre/Esr1*)1Egwa/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdr^tm1.1Jamb mutation (0 available); any Kdr mutation (74 available)
Kdr^tm1Jrt mutation (1 available); any Kdr mutation (74 available)
Tg(CAG-cre/Esr1*)1Egwa mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Suppression of of extraretinal vascular outgrowth in ischemic Kdr^tm1.1Jamb/Kdr^tm1Jrt Tg(CAG-cre/Esr1*)1Egwa/0 retinas

cardiovascular system

abnormal induced retina neovascularization ( J:173943 )

• tamoxifen-treated mice exhibit decreased extraretinal vascular outgrowth in ischemic retinas compared with control mice

vision/eye

abnormal induced retina neovascularization ( J:173943 )

• tamoxifen-treated mice exhibit decreased extraretinal vascular outgrowth in ischemic retinas compared with control mice

Allelic Composition	Kdr^tm1Jrt/Kdr⁺ Prdm1^tm2Rob/Prdm1^tm2Rob
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdr^tm1Jrt mutation (1 available); any Kdr mutation (74 available)
Prdm1^tm2Rob mutation (0 available); any Prdm1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal placental labyrinth vasculature morphology ( J:187742 )

• fetal capillaries fail to extend into the labyrinth tissue and instead are largely restricted to the base of the labyrinth

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:187742 )

• fetal capillaries fail to extend into the labyrinth tissue and instead are largely restricted to the base of the labyrinth

Allelic Composition	Kdr^tm1Jrt/Kdr⁺ Tmem204^tm1.1Ali/Tmem204^tm1.1Ali
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdr^tm1Jrt mutation (1 available); any Kdr mutation (74 available)
Tmem204^tm1.1Ali mutation (0 available); any Tmem204 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal lymphatic vessel smooth muscle morphology ( J:159519 )

• abnormal smooth muscle cell coating

enlarged lymphatic vessel ( J:159519 )

• enlarged lymphatic vessels are even more dilated than in Tmem204^tm1.1Ali single knock-outs

muscle

abnormal lymphatic vessel smooth muscle morphology ( J:159519 )

• abnormal smooth muscle cell coating

Allelic Composition	Kdr^tm1Jrt/Kdr⁺ Rasip1^tm1.1Oncl/Rasip1^tm1.1Oncl
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdr^tm1Jrt mutation (1 available); any Kdr mutation (74 available)
Rasip1^tm1.1Oncl mutation (0 available); any Rasip1 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal vasculogenesis ( J:174152 )

• at E9.5, mice fail to exhibit remodeling of the initial plexus in embryonic tissue unlike wild-type mice

embryo

abnormal vitelline vascular remodeling ( J:174152 )

• at E9.5, mice fail to exhibit remodeling of the initial plexus in the yolk sac unlike wild-type mice

Allelic Composition	Kdr^tm1Jrt/Kdr⁺ Tg(tetO-Kdr*)4377.5Rwng/0 Tg(Cebpb-tTA)5Bjd/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * FVB/N * NMRI

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdr^tm1Jrt mutation (1 available); any Kdr mutation (74 available)
Tg(Cebpb-tTA)5Bjd mutation (3 available)
Tg(tetO-Kdr*)4377.5Rwng mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

abnormal liver development ( J:100427 )

• at E12.5, liver vasculature is less organized and vessels are dilated

• at E13.5, microvascular network is more disorganized with fewer branches than in control livers; newborns have very little microvascular network is observed

Allelic Composition	Flt1^tm2Msh/Flt1^tm2Msh Kdr^tm1Jrt/Kdr^tm1Jrt
Genetic Background	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt1^tm2Msh mutation (1 available); any Flt1 mutation (76 available)
Kdr^tm1Jrt mutation (1 available); any Kdr mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality ( J:95387 )

• all of the double homozygotes die as embryos

cardiovascular system

abnormal vascular endothelial cell migration ( J:95387 )

• Kdr+ cells (lacZ expressing) abnormally accumulate in the posterior portion of the embryo

cellular

abnormal vascular endothelial cell migration ( J:95387 )

• Kdr+ cells (lacZ expressing) abnormally accumulate in the posterior portion of the embryo

Allelic Composition	Flt1^tm2Msh/Flt1^tm2Msh Kdr^tm1Jrt/Kdr⁺
Genetic Background	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:95387 )

• about 90% of mutants die as embryos

cardiovascular system

abnormal vascular endothelial cell differentiation ( J:95387 )

• differentiation of vascular endothelial cells is disturbed

abnormal vascular endothelial cell migration ( J:95387 )

• Kdr+ cells (lacZ expressing) abnormally accumulate in the middle to posterior portion of the embryo

cellular

abnormal vascular endothelial cell differentiation ( J:95387 )

• differentiation of vascular endothelial cells is disturbed

abnormal vascular endothelial cell migration ( J:95387 )

• Kdr+ cells (lacZ expressing) abnormally accumulate in the middle to posterior portion of the embryo

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24