Phenotypes associated with this allele

• Allele Symbol: Gabra6^tm1Geh
• Allele Name: targeted mutation 1, Gregg E Homanics
• Allele ID: MGI:1857173
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gabra6^tm1Geh/Gabra6^tm1Geh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:2177605

Genotype
MGI:2177605

hm1

• Allelic Composition: Gabra6^tm1Geh/Gabra6^tm1Geh
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:46680 )

N • ability to clear ethanol from the blood did not differ from controls

abnormal xenobiotic pharmacokinetics ( J:40242 )

• homozygotes exhibit a decrease in the affinity of cerebellar GABA receptors for muscimol, a potent GABA mimetic drug, suggesting that the alpha 6 subunit is responsible for binding this drug

• diazepam, a benzodiazepine drug, displaces all GABA analog binding in the homozygous brain, while this drug does not displace such binding in alpha 6 subunit containing GABA receptors in control brain

• however, behavioral responses to ethanol, pentobarbitol, halothane and enflurane were not different from controls

• behavioral responses to ethanol treatment are not significantly different from controls; functional tolerance, withdrawal hyperexcitability and protracted tolerance tests were similar to both C57BL/6J and 129X1/SvJ control strains

nervous system

nervous system phenotype ( J:40242 )

N • immunohistochemical analysis indicates that the general morphology and cytoarchitecture of the cerebellum of knockout mice is similar to controls

behavior/neurological

behavior/neurological phenotype ( J:46680 )

N • behavioral responses to ethanol treatment are not significantly different from controls; functional tolerance, withdrawal hyperexcitability and protracted tolerance tests were similar to both C57BL/6J and 129X1/SvJ control strains