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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lipctm1Unc
targeted mutation 1, University of North Carolina
MGI:1857182
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lipctm1Unc/Lipctm1Unc B6.129P2-Lipctm1Unc MGI:3849891
hm2
 		Lipctm1Unc/Lipctm1Unc involves: 129 MGI:2182076
hm3
 		Lipctm1Unc/Lipctm1Unc involves: 129P2/OlaHsd * C57BL/6J MGI:3582524
cx4
 		Ldlrtm1Her/Ldlrtm1Her
Lipctm1Unc/Lipctm1Unc 		involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 MGI:4367222


Genotype
MGI:3849891
hm1
Allelic
Composition		 Lipctm1Unc/Lipctm1Unc
Genetic
Background		 B6.129P2-Lipctm1Unc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lipctm1Unc mutation (4 available); any Lipc mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating corticosterone level ( J:108412 )
• levels in response to ACTH are significantly reduced
increased circulating cholesterol level ( J:120962 )
• mice have elevated levels of serum cholesterol (>200 mg/dl)
increased circulating triglyceride level ( J:120962 )
• mice have elevated levels of triglycerides




Genotype
MGI:2182076
hm2
Allelic
Composition		 Lipctm1Unc/Lipctm1Unc
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lipctm1Unc mutation (4 available); any Lipc mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating HDL cholesterol level ( J:22938 )
• levels are only significantly elevated in females
• increased 2X on a high fat diet
abnormal circulating phospholipid level ( J:22938 )
• significantly increased




Genotype
MGI:3582524
hm3
Allelic
Composition		 Lipctm1Unc/Lipctm1Unc
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lipctm1Unc mutation (4 available); any Lipc mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating HDL cholesterol level ( J:22938 )
• levels are only significantly elevated in females
• increased 2X on a high fat diet
abnormal circulating phospholipid level ( J:22938 )
• significantly increased

reproductive system
small ovary ( J:75665 )
• ovary size is reduced 20-40% subsequent to superovulation
decreased ovulation rate ( J:75665 )
• about half as many oocytes released as normal
decreased litter size ( J:75665 )
• by an average of 1.7 pups per litter

endocrine/exocrine glands
small ovary ( J:75665 )
• ovary size is reduced 20-40% subsequent to superovulation




Genotype
MGI:4367222
cx4
Allelic
Composition		 Ldlrtm1Her/Ldlrtm1Her
Lipctm1Unc/Lipctm1Unc
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (19 available); any Ldlr mutation (81 available)
Lipctm1Unc mutation (4 available); any Lipc mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating corticosterone level ( J:108412 )
• levels in response to ACTH are significantly reduced
increased circulating cholesterol level ( J:108412 )
• levels markedly increased
• primarily in HDL and LDL fractions




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory