endocrine/exocrine glands
• in a few mice
|
mortality/aging
• sudden death occurs 5 to 7 weeks after infection with Leishmania major
(J:18801)
• die earlier after inoculation with Toxoplasma gondii (strain ME49) compared to wild-type controls
(J:110826)
|
• higher mortality is seen following infection with JHMV compared to wild-type controls
|
• Background Sensitivity: in mice on a C57BL/6 background compared to mice on a BALB/c background
|
neoplasm
• Background Sensitivity: 50% of mice on a congenic C57BL/5 background develop disseminated lymphomas compared to 0% of mice on a congenic BALB/c background
• most lymphomas are diffuse large cell lymphomas
|
• in a few mice
|
• in a few mice
|
• Background Sensitivity: in mice on a C57BL/6 background compared to mice on a BALB/c background
|
immune system
• in a few mice
|
• increase in the number of CD8+ cells in the white matter tracts of JHMV infected mice compared to similarly infected wild-type controls at 7 and 14 days post infection
|
• immature B cells fail to be excluded from the lymph nodes
|
• after infection with Leishmania major
|
• after infection with Leishmania major
(J:18801)
• 5-fold increase in the serum levels of JHMV specific IgG1 at 14 days post infection compared to infected wild-type controls
(J:112048)
|
• after infection with Leishmania major
|
• after infection with Leishmania major
|
• significant increase in the numbers of immature B cells in the lymph nodes
|
• after infection with Leishmania major the number of lymphocytes producing IL4 increases unlike in control mice where the number of lymphocytes producing IFNG increases
(J:18801)
• following infection with T. gondii (irradiate RH strain) splenocytes show enhanced Th2 cytokine production compared to similar cultures from wild-type mice
(J:110826)
|
• cervical lymph node cells from JHMV infected mice (7 days post infection) secrete more IL10 in response to JHMV antigen compared to cells from similarly infected wild-type mice
|
• cervical lymph node cells from JHMV infected mice secrete more IL2 in response to JHMV antigen compared to cells from similarly infected wild-type mice
|
• cervical lymph node cells from JHMV infected mice (7 days post infection) secrete more IL5 in response to JHMV antigen compared to cells from similarly infected wild-type mice
|
• after infection with Leishmania major mice display minimal Th1 type responses and increased Th2 type responses
(J:18801)
• after infection with Leishmania major levels of IgG1 and IgE are increased while levels of IgG2a and IgG3 remain low
(J:18801)
• following infection with T. gondii (irradiate RH strain) splenocytes show enhanced Th2 cytokine production compared to similar cultures from wild-type mice
(J:110826)
|
• develop progressive infection characterized by large lesions at the site of inoculation and sudden death 5 to 7 weeks after infection with Leishmania major
• numbers of parasites present in the footpads are substantially increased compared to wild-type and heterozygous controls
|
• sudden death occurs 5 to 7 weeks after infection with Leishmania major
(J:18801)
• die earlier after inoculation with Toxoplasma gondii (strain ME49) compared to wild-type controls
(J:110826)
|
• following infection with the JHM strain of mouse hepatitis virus (JHMV) mice display a slower clinical recovery and higher viral titers in the central nervous system compared to wild-type controls
• however, no differences are found in JHMV specific cytotoxic T lymphocyte activity
• at 14 days post infection with JHMV a 10 fold increase in the number of viral antigen positive cells is detected in the brain with most of the infected cells being oligodendrocytes
|
• higher mortality is seen following infection with JHMV compared to wild-type controls
|
• after immunosuppressive treatment (anti-CD4 and anti-CD8 mAbs) allografts (BALB/c, H2-Ab1bm12 continue to display myocardial rejection at week 12 but do not display graft arterial disease, in contrast wild-type mice at week 12 display low levels of rejection but develop coronary arteriopathy
|
hematopoietic system
• in a few mice
|
• increase in the number of CD8+ cells in the white matter tracts of JHMV infected mice compared to similarly infected wild-type controls at 7 and 14 days post infection
|
• immature B cells fail to be excluded from the lymph nodes
|
• after infection with Leishmania major
|
• after infection with Leishmania major
(J:18801)
• 5-fold increase in the serum levels of JHMV specific IgG1 at 14 days post infection compared to infected wild-type controls
(J:112048)
|
• after infection with Leishmania major
|
• after infection with Leishmania major
|