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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Igkctm1Cgn
targeted mutation 1, University of Cologne
MGI:1857188
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Igkctm1Cgn/Igkctm1Cgn involves: C57BL/6 MGI:2179236
ht2
 		Igkctm1Cgn/Igkc+ involves: C57BL/6 MGI:2179237


Genotype
MGI:2179236
hm1
Allelic
Composition		 Igkctm1Cgn/Igkctm1Cgn
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igkctm1Cgn mutation (2 available); any Igkc mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:64287 )
• 50% decrease in recombination of the Jk-kappa and V-kappa gene segments in splenic B cells
increased immature B cell number ( J:64287 )
• the percentage of immature B cells in bone marrow is double that of wild-type
decreased mature B cell number ( J:64287 )
• 2.3 fold less B cells in the spleen
• B cells expressing kappa chain completely absent in the spleen
• the percentage of newly generated B cell in the bone marrow is half that of wild-type
increased mature B cell number ( J:64287 )
• 7 fold increase of lambda-chain expressing B cells
spleen hypoplasia ( J:64287 )
• 30% fewer nucleated cells found in the spleen

hematopoietic system
abnormal B cell differentiation ( J:64287 )
• 50% decrease in recombination of the Jk-kappa and V-kappa gene segments in splenic B cells
increased immature B cell number ( J:64287 )
• the percentage of immature B cells in bone marrow is double that of wild-type
decreased mature B cell number ( J:64287 )
• 2.3 fold less B cells in the spleen
• B cells expressing kappa chain completely absent in the spleen
• the percentage of newly generated B cell in the bone marrow is half that of wild-type
increased mature B cell number ( J:64287 )
• 7 fold increase of lambda-chain expressing B cells
spleen hypoplasia ( J:64287 )
• 30% fewer nucleated cells found in the spleen




Genotype
MGI:2179237
ht2
Allelic
Composition		 Igkctm1Cgn/Igkc+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igkctm1Cgn mutation (2 available); any Igkc mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased mature B cell number ( J:64287 )
• 2 fold increase of lambda-chain expressing B cells

hematopoietic system
increased mature B cell number ( J:64287 )
• 2 fold increase of lambda-chain expressing B cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory