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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Igll1tm1Cgn
targeted mutation 1, University of Cologne
MGI:1857189
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Igll1tm1Cgn/Igll1tm1Cgn involves: 129S2/SvPas * C57BL/6 MGI:2179332
cx2
Igktm1Rsky/Igk+
Igll1tm1Cgn/Igll1tm1Cgn
involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6 MGI:3689735
cx3
Igll1tm1Cgn/Igll1tm1Cgn
Tg(Igk-V4CH27)1-2Shc/0
involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL MGI:3689734


Genotype
MGI:2179332
hm1
Allelic
Composition
Igll1tm1Cgn/Igll1tm1Cgn
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igll1tm1Cgn mutation (1 available); any Igll1 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• about a 2-fold increase compared to wild-type
• in young (6 weeks of age) but not old (5 - 6 months of age) mice B cells are larger and appear to mostly be activated
• however, cells that do mature display normal allelic exclusion
• in the spleen at 6 - 12 weeks of age, B cell numbers are about 1/3 that of wild-type mice (J:35357)
• at 5-6 weeks of age in the peripheral blood; T cell numbers are similar to wild-type (J:64284)
• at 5-6 weeks of age the ratio of B to T cells in the blood is decreased about 25- to 65-fold relative to wild-type mice and the number of splenic B cells is reduced about 10- to 30-fold (J:64284)
• at 4 months of age, B cells numbers in the blood and spleen are reduced 5- to 13-fold and 3- to 5-fold, respectively (J:64284)
• at 2 weeks of age the number of lymphocytes in the peritoneum is reduced; however, at 5-7 weeks of age the number of B-1 cells in the peritoneum is similar to or increased compared to wild-type mice
• about a 2-fold increase in large early pre-B cells and a 40-fold decrease in small pre-B cells compared to wild-type
• spleen cellularity is reduced about 4-fold and 2-fold at 2 weeks and 5-6 weeks of age, respectively
• decreased levels of IgG3, IgG2b, and, to a lesser degree, IgG1 in response to a T-cell dependent antigen with overall antibody response reduced about 5- to 10-fold

hematopoietic system
• about a 2-fold increase compared to wild-type
• in young (6 weeks of age) but not old (5 - 6 months of age) mice B cells are larger and appear to mostly be activated
• however, cells that do mature display normal allelic exclusion
• in the spleen at 6 - 12 weeks of age, B cell numbers are about 1/3 that of wild-type mice (J:35357)
• at 5-6 weeks of age in the peripheral blood; T cell numbers are similar to wild-type (J:64284)
• at 5-6 weeks of age the ratio of B to T cells in the blood is decreased about 25- to 65-fold relative to wild-type mice and the number of splenic B cells is reduced about 10- to 30-fold (J:64284)
• at 4 months of age, B cells numbers in the blood and spleen are reduced 5- to 13-fold and 3- to 5-fold, respectively (J:64284)
• at 2 weeks of age the number of lymphocytes in the peritoneum is reduced; however, at 5-7 weeks of age the number of B-1 cells in the peritoneum is similar to or increased compared to wild-type mice
• about a 2-fold increase in large early pre-B cells and a 40-fold decrease in small pre-B cells compared to wild-type
• spleen cellularity is reduced about 4-fold and 2-fold at 2 weeks and 5-6 weeks of age, respectively
• decreased levels of IgG3, IgG2b, and, to a lesser degree, IgG1 in response to a T-cell dependent antigen with overall antibody response reduced about 5- to 10-fold




Genotype
MGI:3689735
cx2
Allelic
Composition
Igktm1Rsky/Igk+
Igll1tm1Cgn/Igll1tm1Cgn
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igktm1Rsky mutation (1 available); any Igk mutation (26 available)
Igll1tm1Cgn mutation (1 available); any Igll1 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• only 5.5% of CD43+ B cell progenitors express the kappa chain in the cytoplasm compared to 22% of wild-type cells at a similar developmental stage which express a kappa chain
• about a 5-fold reduction in immature B cell numbers compared to wild-type mice, but a 3-fold increase compared to Igll1 mutant mice wild-type at the Igk locus
• about a 5-fold reduction in mature and immature B cell numbers compared to wild-type mice, but a 3-fold increase compared to Igll1 mutant mice wild-type at the Igk locus
• in the spleen at 6 - 12 weeks of age, B cell numbers are about 1/3 that of wild-type mice
• about a 5-fold reduction in mature B cell numbers compared to wild-type mice, but a 3-fold increase compared to Igll1 mutant mice wild-type at the Igk locus
• about a 3-fold reduction compared to wild-type mice

hematopoietic system
• only 5.5% of CD43+ B cell progenitors express the kappa chain in the cytoplasm compared to 22% of wild-type cells at a similar developmental stage which express a kappa chain
• about a 5-fold reduction in immature B cell numbers compared to wild-type mice, but a 3-fold increase compared to Igll1 mutant mice wild-type at the Igk locus
• about a 5-fold reduction in mature and immature B cell numbers compared to wild-type mice, but a 3-fold increase compared to Igll1 mutant mice wild-type at the Igk locus
• in the spleen at 6 - 12 weeks of age, B cell numbers are about 1/3 that of wild-type mice
• about a 5-fold reduction in mature B cell numbers compared to wild-type mice, but a 3-fold increase compared to Igll1 mutant mice wild-type at the Igk locus
• about a 3-fold reduction compared to wild-type mice




Genotype
MGI:3689734
cx3
Allelic
Composition
Igll1tm1Cgn/Igll1tm1Cgn
Tg(Igk-V4CH27)1-2Shc/0
Genetic
Background
involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igll1tm1Cgn mutation (1 available); any Igll1 mutation (16 available)
Tg(Igk-V4CH27)1-2Shc mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• more than 80% of CD43+ B cell progenitors express the transgene in the cytoplasm, compared to only 22% of wild-type cells at a similar developmental stage which express a kappa chain
• about a 3- to 4-fold reduction in pre-B cells; however, the overall numbers of immature and mature B cell numbers are similar to wild-type

hematopoietic system
• more than 80% of CD43+ B cell progenitors express the transgene in the cytoplasm, compared to only 22% of wild-type cells at a similar developmental stage which express a kappa chain
• about a 3- to 4-fold reduction in pre-B cells; however, the overall numbers of immature and mature B cell numbers are similar to wild-type





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory