Phenotypes associated with this allele

• Allele Symbol: Cd74^tm2Liz
• Allele Name: targeted mutation 2, Elizabeth K Bikoff
• Allele ID: MGI:1857190
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd74^tm2Liz/Cd74^tm2Liz	involves: 129S/SvEv * C57BL/6	MGI:3688894
ht2	Cd74^tm2Liz/Cd74^tm1Liz	involves: 129S/SvEv * C57BL/6	MGI:3688837

Genotype
MGI:3688894

hm1

• Allelic Composition: Cd74^tm2Liz/Cd74^tm2Liz
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased interleukin-2 secretion ( J:72243 )

• T cells from immunized mice secrete less Il-2 than wild-type cells, but show a similar proliferative response

increased susceptibility to experimental autoimmune encephalomyelitis ( J:72243 )

• direct immunization with p35-55 results in development of experimental autoimmune encephalitis (EAE); after initial onset of EAE, disease course is more severe than in wild-type and 2-fold greater than in invariant chain isoform p41 mutants

Genotype
MGI:3688837

ht2

• Allelic Composition: Cd74^tm2Liz/Cd74^tm1Liz
• Genetic Background: involves: 129S/SvEv * C57BL/6

immune system

immune system phenotype ( J:28966 )

N • compact Aalpha^bAbeta^b dimers are produced efficiently in absence of invariant chain p41 isoform

N • mutants show no significant differences in level of class II expressed on spleen cells compared to wild-type

N • normal numbers of CD4+CD8- T cells are observed compared to Cd74^tm1Liz

increased T cell proliferation ( J:28966 )

• lymph node cells show equivalent proliferative responses to KLH immunization compared to those from heterozygous littermates, but greater than wild-type cells

abnormal antigen presentation via MHC class II ( J:28966 )

• cell expressing the p31 invariant chain (lacking p41 chain) can present native protein antigens including keyhole limpet cyanin (KLH), ovalbumin (OVA), and IgG2a^a compared to complete invariant chain deficient spleen cells

hematopoietic system

increased T cell proliferation ( J:28966 )

• lymph node cells show equivalent proliferative responses to KLH immunization compared to those from heterozygous littermates, but greater than wild-type cells

cellular

increased T cell proliferation ( J:28966 )

• lymph node cells show equivalent proliferative responses to KLH immunization compared to those from heterozygous littermates, but greater than wild-type cells