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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il4tm2Nnt
targeted mutation 2, Nancy Noben-Trauth
MGI:1857195
Summary 3 genotypes


Genotype
MGI:5432612
hm1
Allelic
Composition		 Il4tm2Nnt/Il4tm2Nnt
Genetic
Background		 BALB/c-Il4tm2Nnt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4tm2Nnt mutation (3 available); any Il4 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to parasitic infection induced morbidity/mortality ( J:60609 )
• increased mortality following acute infection with Schistosoma mansoni compared to wild-type mice

immune system
ileum inflammation ( J:60609 )
• marked distension and inflammation of the ileum in S. mansoni infected mice
• circulating levels of LPS in S. mansoni infected mice are elevated indicating impaired integrity of the gut
• T cells in the intestine have a Th1 like phenotype in S. mansoni infected mice rather than the Th2 like phenotype seen in wild-type mice
abnormal splenocyte physiology ( J:60609 )
• display a diminished type 2 cytokine response in response to soluble schistosome egg antigens compared to wild-type cells
abnormal susceptibility to infection ( J:60609 )
• T cells in the intestine have a Th1 like phenotype in S. mansoni infected mice rather than the Th2 like phenotype seen in wild-type mice
increased susceptibility to parasitic infection ( J:60609 )
• increase in S. mansoni infection induced liver damage measured by plasma aspartate aminotransferase levels compared to wild-type mice
• marked distension and inflammation of the ileum in S. mansoni infected mice and impaired parasite egg excretion compared to wild-type mice
increased susceptibility to parasitic infection induced morbidity/mortality ( J:60609 )
• increased mortality following acute infection with Schistosoma mansoni compared to wild-type mice

hematopoietic system
abnormal splenocyte physiology ( J:60609 )
• display a diminished type 2 cytokine response in response to soluble schistosome egg antigens compared to wild-type cells

digestive/alimentary system
ileum inflammation ( J:60609 )
• marked distension and inflammation of the ileum in S. mansoni infected mice
• circulating levels of LPS in S. mansoni infected mice are elevated indicating impaired integrity of the gut
• T cells in the intestine have a Th1 like phenotype in S. mansoni infected mice rather than the Th2 like phenotype seen in wild-type mice




Genotype
MGI:2179958
hm2
Allelic
Composition		 Il4tm2Nnt/Il4tm2Nnt
Genetic
Background		 BALB/c-Il4tm2Nnt/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4tm2Nnt mutation (3 available); any Il4 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
alveolar process atrophy ( J:147935 )
• increase in alveolar bone loss at 30 weeks relative to mice at 6 and 16 weeks

immune system
abnormal dendritic cell differentiation ( J:141937 )
• numbers of MHCII/CD86-positive dendritic cells found in inflamed lungs are reduced by two-thirds
decreased IgE level ( J:31486 )
• reduced serum concentrations of IgE, however lymphocyte composition and function comparable to wild-type controls
decreased IgG1 level ( J:31486 )
• reduced serum concentrations of IgG1, however lymphocyte composition and function comparable to wild-type controls
abnormal dendritic cell antigen presentation ( J:141937 )
• memory CD4 T cells activated by mutant DCs from inflamed lungs secrete low levels of Th2 cytokines
increased interferon-gamma secretion ( J:141937 )
• T cells from mice sensitized and challenged with OVA produce more IFN-gamma than controls
decreased interleukin-13 secretion ( J:141937 )
• lymphocytes from mice sensitized and challenged with OVA produce less IL-13 than controls
decreased interleukin-5 secretion ( J:141937 )
• lymphocytes from mice sensitized and challenged with OVA produce less IL-5 than controls
decreased susceptibility to autoimmune disorder ( J:141937 )
• mice fail to develop blood eosinophilia after being sensitized and challenged with OVA peptide
• airway hyperresponsiveness still occurs in these mice though less mucosal cells are found in the inflamed airway

hematopoietic system
abnormal dendritic cell differentiation ( J:141937 )
• numbers of MHCII/CD86-positive dendritic cells found in inflamed lungs are reduced by two-thirds
decreased IgE level ( J:31486 )
• reduced serum concentrations of IgE, however lymphocyte composition and function comparable to wild-type controls
decreased IgG1 level ( J:31486 )
• reduced serum concentrations of IgG1, however lymphocyte composition and function comparable to wild-type controls

craniofacial
alveolar process atrophy ( J:147935 )
• increase in alveolar bone loss at 30 weeks relative to mice at 6 and 16 weeks

skeleton
alveolar process atrophy ( J:147935 )
• increase in alveolar bone loss at 30 weeks relative to mice at 6 and 16 weeks

cellular
abnormal dendritic cell differentiation ( J:141937 )
• numbers of MHCII/CD86-positive dendritic cells found in inflamed lungs are reduced by two-thirds

renal/urinary system
abnormal kidney physiology ( J:84825 )
• functional and histological markers for damage after ischemia are elevated




Genotype
MGI:3721951
cx3
Allelic
Composition		 Il4tm2Nnt/Il4tm2Nnt
Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic
Background		 C.Cg-Tgfb1tm1Doe Il4tm2Nnt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4tm2Nnt mutation (3 available); any Il4 mutation (46 available)
Tgfb1tm1Doe mutation (4 available); any Tgfb1 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:69346 )
• average survival is 13.6 days (range 10-19.5 days)

homeostasis/metabolism
increased circulating alanine transaminase level ( J:69346 )
• extensive inflammation is observed

immune system

liver/biliary system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory