Analysis Tools
immune system
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• 5 weeks after Helicobacter pylori infection, mice have a significantly increased gastritis inflammation score compared to infected wild-type mice
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• microglial cells fail to express the cell marker Ym1 (Chi3l3)
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• there is enhanced IgA production by lymphocytes isolated from either the spleen or liver granulomas after schistosome infection
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• lymphocytes from the spleen or from liver granulomas fail to secrete IgE in response to Schistosoma mansoni infection
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• serum IgG1 levels are dramatically decreased in response to schistosome infection compared to the wild-type response
• isolated lymphocytes from the spleen or from liver granulomas produce very little IgG1 in culture
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• very little IgM is produced by lymphocytes that are isolated from liver granulomas
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• lymphocytes isolated from liver granulomas resulting from schistosome infection lack a strong Th2 response
• the lack of Th2 response is reflected in no secretion of IL-4, IL-5, and a 50% reduction in IL-10 by lymphocytes isolated from liver granulomas
• liver granuloma lymphocytes make small amounts of IFN-gamma compared to wild-type lymphocytes that make no IFN-gamma
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• lymphocytes isolated from liver granulomas produce dectectable amounts of IFN-gamma compared to wild-type lymphocytes that produce no IFN-gamma
(J:37196)
• splenocytes from Helicobacter pylori-infected mice produce log fold higher amounts of IFN-gamma than splenocytes from wild-type controls when cultured in the presence of H. pylori antigen
(J:120556)
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• activated splenic lymphocytes fail to secrete IL-10
(J:37196)
• IL-10 secretion by lymphocytes isolated from liver granulomas is also severely impaired
(J:37196)
• splenocytes from Helicobacter pylori infected mice produce 4-fold less IL-10 when cultured in the presence of H. pylori antigen
(J:120556)
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• lymphocytes make no IL-4
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• secretion of IL-5 is almost absent by unactivated lymphocytes isolated from liver granulomas
• activated lymphocytes from liver granulomas produced 50% IL-5 compared to controls
• secretion of IL-5 by activated splenic lymphocytes is also severely impaired
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• mice generate 32% smaller liver granulomas than wild-type mice in response to schistosome ova 8 weeks after infection
• the granulomas contain few eosinophils and no mast cells compared to their wild-type counterparts
• granulomas contain2-fold more lymphocytes and 42% more macrophages than in wild-type mice
• the number of B cells in the liver granulomas increases more than 2-fold while the number of CD4 T cells decreases by almost the same amount
• B cells in granulomas have lower surface expression of Class II and IgE receptor
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• lethally irradiated mutant mice can be transplanted with bone marrow from wild-type mice and then have encephalomyelitis induced by injection of an inflammatory antigen
• these bone marrow chimera mice exhibit more severe inflammation with a 2-fold increase in the number of infiltrating lymphocytes, higher disease score, and earlier onset of disease
• the number of infiltrating macrophages and activated resident microglial cells are also increased in these bone marrow chimeras as a result of encephalomyelitis induction
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digestive/alimentary system
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• 5 weeks after Helicobacter pylori infection, mice have a significantly increased gastritis inflammation score compared to infected wild-type mice
|
hematopoietic system
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• microglial cells fail to express the cell marker Ym1 (Chi3l3)
|
|
• there is enhanced IgA production by lymphocytes isolated from either the spleen or liver granulomas after schistosome infection
|
|
• lymphocytes from the spleen or from liver granulomas fail to secrete IgE in response to Schistosoma mansoni infection
|
|
• serum IgG1 levels are dramatically decreased in response to schistosome infection compared to the wild-type response
• isolated lymphocytes from the spleen or from liver granulomas produce very little IgG1 in culture
|
|
• very little IgM is produced by lymphocytes that are isolated from liver granulomas
|
|
• lymphocytes isolated from liver granulomas resulting from schistosome infection lack a strong Th2 response
• the lack of Th2 response is reflected in no secretion of IL-4, IL-5, and a 50% reduction in IL-10 by lymphocytes isolated from liver granulomas
• liver granuloma lymphocytes make small amounts of IFN-gamma compared to wild-type lymphocytes that make no IFN-gamma
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nervous system
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• microglial cells fail to express the cell marker Ym1 (Chi3l3)
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|
• lethally irradiated mutant mice can be transplanted with bone marrow from wild-type mice and then have encephalomyelitis induced by injection of an inflammatory antigen
• these bone marrow chimera mice exhibit more severe inflammation with a 2-fold increase in the number of infiltrating lymphocytes, higher disease score, and earlier onset of disease
• the number of infiltrating macrophages and activated resident microglial cells are also increased in these bone marrow chimeras as a result of encephalomyelitis induction
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