All Phenotypes Il12a<tm1Jm> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Il12a^tm1Jm
targeted mutation 1, Jeanne Magram
MGI:1857200

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il12a^tm1Jm/Il12a^tm1Jm	129S1/Sv-Il12a^tm1Jm	MGI:2179408
hm2	Il12a^tm1Jm/Il12a^tm1Jm	B6.129S1-Il12a^tm1Jm	MGI:3713194
hm3	Il12a^tm1Jm/Il12a^tm1Jm	B6.129S1-Il12a^tm1Jm/J	MGI:3691130
hm4	Il12a^tm1Jm/Il12a^tm1Jm	C.129S1-Il12a^tm1Jm	MGI:3784442
hm5	Il12a^tm1Jm/Il12a^tm1Jm	involves: 129S1/Sv	MGI:3809649
cx6	Il12a^tm1Jm/Il12a^tm1Jm Il12b^tm1Jm/Il12b^tm1Jm	B6.129S1-Il12a^tm1Jm Il12b^tm1Jm	MGI:3784444
cx7	Il12a^tm1Jm/Il12a^tm1Jm Rag2^tm1Fwa/Rag2^tm1Fwa	involves: 129S/SvEv * 129S1/Sv * 129S6/SvEvTac	MGI:3817880

Allelic Composition	Il12a^tm1Jm/Il12a^tm1Jm
Genetic Background	129S1/Sv-Il12a^tm1Jm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il12a^tm1Jm mutation (2 available); any Il12a mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal CD4-positive, alpha-beta T cell physiology ( J:34164 )

• 75 days after infection Il4 mRNA expression in CD4+ cells is 100-fold higher than in wild-type

• 75 days after infection Ifng mRNA expression in CD4+ cells is more than 50-fold lower than in wild-type

• draining lymph node cells in L. major infected mice produce significantly more IL4 compared to IFNG in contrast to wild-type mice which express more IFNG than IL4

decreased susceptibility to type IV hypersensitivity reaction ( J:34164 )

• do not show any delayed type hypersensitivity response to application of Leishmania antigen to the uninfected footpad 41 days after initial infection with L. major

increased susceptibility to parasitic infection ( J:34164 )

• develop large lesions unlike wild-type 129S1/Sv mice after infection with Leishmania major

• 75 days after infection with L. major parasite numbers in the draining lymph nodes are increased 80-fold compared to wild-type mice

hematopoietic system

abnormal CD4-positive, alpha-beta T cell physiology ( J:34164 )

• 75 days after infection Il4 mRNA expression in CD4+ cells is 100-fold higher than in wild-type

• 75 days after infection Ifng mRNA expression in CD4+ cells is more than 50-fold lower than in wild-type

• draining lymph node cells in L. major infected mice produce significantly more IL4 compared to IFNG in contrast to wild-type mice which express more IFNG than IL4

Allelic Composition	Il12a^tm1Jm/Il12a^tm1Jm
Genetic Background	B6.129S1-Il12a^tm1Jm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il12a^tm1Jm mutation (2 available); any Il12a mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:120806 )

N	• no abnormal response to infection is detected

Allelic Composition	Il12a^tm1Jm/Il12a^tm1Jm
Genetic Background	B6.129S1-Il12a^tm1Jm/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il12a^tm1Jm mutation (2 available); any Il12a mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:91927 )

• increase in mortality following a single dose of N-methyl-N-nitrosourea (MNU) compared to similarly treated wild-type controls

neoplasm

increased incidence of tumors by chemical induction ( J:111568 )

• earlier tumor appearance and increased incidence of papillomas compared to wild-type mice after treatment with DMBA and TPA in a 2 step skin carcinogenesis protocol

• however, resistance to tumor formation following intradermal challenge with with PDV squamous carcinoma cells is similar to wild-type mice

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:91927 )

• increase in mortality following a single dose of N-methyl-N-nitrosourea (MNU) compared to similarly treated wild-type controls

increased incidence of tumors by chemical induction ( J:111568 )

• earlier tumor appearance and increased incidence of papillomas compared to wild-type mice after treatment with DMBA and TPA in a 2 step skin carcinogenesis protocol

• however, resistance to tumor formation following intradermal challenge with with PDV squamous carcinoma cells is similar to wild-type mice

Allelic Composition	Il12a^tm1Jm/Il12a^tm1Jm
Genetic Background	C.129S1-Il12a^tm1Jm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il12a^tm1Jm mutation (2 available); any Il12a mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

impaired natural killer cell mediated cytotoxicity ( J:125611 )

• following infection with Leishmania infantum

hematopoietic system

impaired natural killer cell mediated cytotoxicity ( J:125611 )

• following infection with Leishmania infantum

Allelic Composition	Il12a^tm1Jm/Il12a^tm1Jm
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il12a^tm1Jm mutation (2 available); any Il12a mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal NK cell physiology ( J:139001 )

• NK cells in vivo make much about 7-fold less IFN-gamma in response to injections of the TLR9 agonist CpG

hematopoietic system

abnormal NK cell physiology ( J:139001 )

• NK cells in vivo make much about 7-fold less IFN-gamma in response to injections of the TLR9 agonist CpG

Allelic Composition	Il12a^tm1Jm/Il12a^tm1Jm Il12b^tm1Jm/Il12b^tm1Jm
Genetic Background	B6.129S1-Il12a^tm1Jm Il12b^tm1Jm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il12a^tm1Jm mutation (2 available); any Il12a mutation (35 available)
Il12b^tm1Jm mutation (4 available); any Il12b mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

impaired natural killer cell mediated cytotoxicity ( J:125611 )

• following infection with Leishmania infantum

hematopoietic system

impaired natural killer cell mediated cytotoxicity ( J:125611 )

• following infection with Leishmania infantum

Allelic Composition	Il12a^tm1Jm/Il12a^tm1Jm Rag2^tm1Fwa/Rag2^tm1Fwa
Genetic Background	involves: 129S/SvEv * 129S1/Sv * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il12a^tm1Jm mutation (2 available); any Il12a mutation (35 available)
Rag2^tm1Fwa mutation (45 available); any Rag2 mutation (119 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal interferon secretion ( J:140483 )

• splenocytes produce minimal levels of Ifng in response to mycobacterial stimulation, in contrast to response of Rag2-null cells

lung inflammation ( J:140483 )

• mice have higher numbers of lesions than Il2b, Rag2-null mice, but size of inflammatory foci and percentage of lung space affected is lower but lesions contain similar numbers of neutrophils

decreased susceptibility to bacterial infection ( J:140483 )

• mice display transiently increased resistance to infection by M. tuberculosis relative to Il12b, Rag2-double null mice which die about 3 days sooner

• pulmonary bacterial loads are slightly but significantly decreased compared to Il12b, Rag2-null mutants

respiratory system

lung inflammation ( J:140483 )

• mice have higher numbers of lesions than Il2b, Rag2-null mice, but size of inflammatory foci and percentage of lung space affected is lower but lesions contain similar numbers of neutrophils

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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