Phenotypes associated with this allele

• Allele Symbol: Inhbb^tm1Jae
• Allele Name: targeted mutation 1, Rudolf Jaenisch
• Allele ID: MGI:1857203
• Summary: 6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Inhbb^tm1Jae/Inhbb^tm1Jae	B6.129S4-Inhbb^tm1Jae	MGI:5319778
hm2	Inhbb^tm1Jae/Inhbb^tm1Jae	either: (129S4/SvJae-Inhbb^tm1Jae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)	MGI:2180182
cn3	Inhba^tm1Zuk/Inhba^tm3Zuk Inhbb^tm1Jae/Inhbb^tm1Jae Amhr2^tm3(cre)Bhr/Amhr2^+	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J	MGI:3758888
cx4	Inhba^tm1Zuk/Inhba^+ Inhbb^tm1Jae/Inhbb^tm1Jae	involves: 129S4/SvJae * 129S7/SvEvBrd	MGI:3758890
cx5	Inhba^tm1Zuk/Inhba^tm1Zuk Inhbb^tm1Jae/Inhbb^tm1Jae	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6	MGI:2180166
cx6	Inhba^tm1Zuk/Inhba^tm3Zuk Inhbb^tm1Jae/Inhbb^tm1Jae	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J	MGI:3758893

Genotype
MGI:5319778

hm1

• Allelic Composition: Inhbb^tm1Jae/Inhbb^tm1Jae
• Genetic Background: B6.129S4-Inhbb^tm1Jae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

increased skeletal muscle weight ( J:182827 )

• increased triceps weight in males

abnormal pectoral muscle morphology ( J:182827 )

• increased weight in males and females

Genotype
MGI:2180182

hm2

• Allelic Composition: Inhbb^tm1Jae/Inhbb^tm1Jae
• Genetic Background: either: (129S4/SvJae-Inhbb^tm1Jae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

mortality/aging

pregnancy-related premature death ( J:16995 )

• in some females initiation of labor fails resulting in the death of the female and fetuses in utero

postnatal lethality, incomplete penetrance ( J:16995 )

• Background Sensitivity: at weaning fewer than expected mice survive on a 129S4/SvJae BALB/c background compared to on a 124S4/SvJae C57BL/6 background with both exhibiting decreased survival relative to wild-type mice

reproductive system

long gestation period ( J:16995 )

♀ • most females deliver on E20.5 and some on E21.5 instead of E19.5 as wild-type females do

reduced female fertility ( J:16995 )

♀ • female mice have a reduced ability to produce live offspring regardless of genotype to which they are mated

♀ • female mice give birth to normal sized litters that die within the first day after birth regardless of genotype

♀ • Background Sensitivity: female mice with the 129S4/SvJae BALB/c background are most severely affected

vision/eye

increased incidence of corneal inflammation ( J:16995 )

• increased inflammation of the cornea and eyelids is observed on the first day after birth in mice with open eyelids

abnormal eye morphology ( J:16995 )

• ocular dystrophy is observed in mice whose eyelids were delayed in opening

abnormal cornea epithelium morphology ( J:16995 )

• hyperkeratinization and squamous metaplasia of the corneal epithelium is observed during the first day after birth in mice with open eyelids

cornea opacity ( J:16995 )

• corneal opacification is observed in mice whose eyelids were delayed in opening

delayed eyelid opening ( J:16995 )

• eyelids that were open at birth and subsequently resealed exhibit a delay in reopening

eyelids open at birth ( J:16995 )

• some mice have open eye lids at birth but seal in subsequent days

• Background Sensitivity: fewer mice on the 129S4/SvJae BALB/c background had open eyelids at birth compared to on the 129S4/SvJae C57BL/6 background and no mice on an inbred 129S4/SvJae background had open eyelids at birth

homeostasis/metabolism

increased circulating follicle stimulating hormone level ( J:16995 )

• serum follicle stimulating hormone levels are increased by about 20% relative to in heterozygotes

endocrine/exocrine glands

galactostasis ( J:16995 )

♀ • maternally dependent fetal death is associated with a failure of milk to be ejected as pups fostered by wild-type mice survive

♀ • milk accumulates in the mammary tissue at day 0.5 after delivery

abnormal mammary gland morphology ( J:16995 )

♀ • at 0.5 days after delivery there is an increase in the glandular to adipose tissue ratio

abnormal mammary gland lobule morphology ( J:16995 )

♀ • at 0.5 days after delivery, vacuolation of the lobules of the mammary gland is observed

immune system

increased incidence of corneal inflammation ( J:16995 )

• increased inflammation of the cornea and eyelids is observed on the first day after birth in mice with open eyelids

integument

galactostasis ( J:16995 )

♀ • maternally dependent fetal death is associated with a failure of milk to be ejected as pups fostered by wild-type mice survive

♀ • milk accumulates in the mammary tissue at day 0.5 after delivery

abnormal mammary gland morphology ( J:16995 )

♀ • at 0.5 days after delivery there is an increase in the glandular to adipose tissue ratio

abnormal mammary gland lobule morphology ( J:16995 )

♀ • at 0.5 days after delivery, vacuolation of the lobules of the mammary gland is observed

behavior/neurological

galactostasis ( J:16995 )

♀ • maternally dependent fetal death is associated with a failure of milk to be ejected as pups fostered by wild-type mice survive

♀ • milk accumulates in the mammary tissue at day 0.5 after delivery

Genotype
MGI:3758888

cn3

• Allelic Composition: Inhba^tm1Zuk/Inhba^tm3Zuk; Inhbb^tm1Jae/Inhbb^tm1Jae; Amhr2^tm3(cre)Bhr/Amhr2⁺
• Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

cellular

absent oocytes ( J:125354 )

♀ • 2 of 4 females produce no oocytes upon superovulation

♀ • however, there is no difference in the number of oocytes superovulated in the remaining 2 mice

reproductive system

absent oocytes ( J:125354 )

♀ • 2 of 4 females produce no oocytes upon superovulation

♀ • however, there is no difference in the number of oocytes superovulated in the remaining 2 mice

increased corpora lutea number ( J:125354 )

♀ • at 6 weeks, 8 to 11 weeks, and 3 months of age, the number of corpus luteums is increased compared to Inhba^tm1Zuk/Inhba^tm3Zuk mice

♀ • the expression of a marker (Lhcgr) for healthy corpus luteums is increased relative to Inhba^tm1Zuk/Inhba^tm3Zuk mice

abnormal ovarian follicle morphology ( J:125354 )

♀ • between 8 and 11 weeks, the number of antral follicles is decreased compared to Inhba^tm1Zuk/Inhba^tm3Zuk mice

♀ • at 8 months, follicles with lutenizing granulosa cells and multiple fluid-filled or hemorrhagic cysts are present

abnormal tertiary ovarian follicle morphology ( J:125354 )

♀ • between 8 and 11 weeks, the number of antral follicles is decreased compared to Inhba^tm1Zuk/Inhba^tm3Zuk mice

ovarian follicular cyst ( J:125354 )

♀ • at 8 months, multiple fluid-filled or hemorrhagic cysts are present that are positive for a granulose cell marker but not an epithelial marker

increased ovary weight ( J:125354 )

♀ • by 8 months, the mass of the ovaries has increased 6-fold (31.5+/-2.9 mg compared to 5.2+/-2.9 mg in Inhba^tm1Zuk/Inhba^tm3Zuk mice)

female infertility ( J:125354 )

♀ • females are infertile

growth/size/body

ovarian follicular cyst ( J:125354 )

♀ • at 8 months, multiple fluid-filled or hemorrhagic cysts are present that are positive for a granulose cell marker but not an epithelial marker

increased ovary weight ( J:125354 )

♀ • by 8 months, the mass of the ovaries has increased 6-fold (31.5+/-2.9 mg compared to 5.2+/-2.9 mg in Inhba^tm1Zuk/Inhba^tm3Zuk mice)

homeostasis/metabolism

increased follicle stimulating hormone level ( J:125354 )

endocrine/exocrine glands

increased corpora lutea number ( J:125354 )

♀ • at 6 weeks, 8 to 11 weeks, and 3 months of age, the number of corpus luteums is increased compared to Inhba^tm1Zuk/Inhba^tm3Zuk mice

♀ • the expression of a marker (Lhcgr) for healthy corpus luteums is increased relative to Inhba^tm1Zuk/Inhba^tm3Zuk mice

abnormal ovarian follicle morphology ( J:125354 )

♀ • between 8 and 11 weeks, the number of antral follicles is decreased compared to Inhba^tm1Zuk/Inhba^tm3Zuk mice

♀ • at 8 months, follicles with lutenizing granulosa cells and multiple fluid-filled or hemorrhagic cysts are present

abnormal tertiary ovarian follicle morphology ( J:125354 )

♀ • between 8 and 11 weeks, the number of antral follicles is decreased compared to Inhba^tm1Zuk/Inhba^tm3Zuk mice

ovarian follicular cyst ( J:125354 )

♀ • at 8 months, multiple fluid-filled or hemorrhagic cysts are present that are positive for a granulose cell marker but not an epithelial marker

increased ovary weight ( J:125354 )

♀ • by 8 months, the mass of the ovaries has increased 6-fold (31.5+/-2.9 mg compared to 5.2+/-2.9 mg in Inhba^tm1Zuk/Inhba^tm3Zuk mice)

Genotype
MGI:3758890

cx4

• Allelic Composition: Inhba^tm1Zuk/Inhba⁺; Inhbb^tm1Jae/Inhbb^tm1Jae
• Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

reproductive system

increased corpora lutea number ( J:125354 )

♀ • beginning at 3 months of age and readily identifiable by 8 months of age, the number of corpus luteums is increased relative to Inhba^tm1Zuk/Inhba^tm3Zuk mice

♀ • the expression of a marker (Lhcgr) for healthy corpus luteums is increased relative to Inhba^tm1Zuk/Inhba^tm3Zuk mice

female infertility ( J:125354 )

♀ • 3 of 11 females are infertile

reduced female fertility ( J:125354 )

♀ • the number of litters produced by females is reduced 43% (0.08+/-0.08 litters per month compared 0.89+/-0.04 litters per month in Inhba^tm1Zuk/Inhba^tm3Zuk mice)

♀ • however, there is no difference in the number of oocytes produced upon superovulation compared to Inhba^tm1Zuk/Inhba^tm3Zuk females

decreased litter size ( J:125354 )

• the number of pups per litter is decreased 33% relative (.80+/-0.49 pups per litter compared to 7.78+/-0.48 pups per litter in Inhba^tm1Zuk/Inhba^tm3Zuk mice)

endocrine/exocrine glands

increased corpora lutea number ( J:125354 )

♀ • beginning at 3 months of age and readily identifiable by 8 months of age, the number of corpus luteums is increased relative to Inhba^tm1Zuk/Inhba^tm3Zuk mice

♀ • the expression of a marker (Lhcgr) for healthy corpus luteums is increased relative to Inhba^tm1Zuk/Inhba^tm3Zuk mice

Genotype
MGI:2180166

cx5

• Allelic Composition: Inhba^tm1Zuk/Inhba^tm1Zuk; Inhbb^tm1Jae/Inhbb^tm1Jae
• Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

mortality/aging

neonatal lethality, incomplete penetrance ( J:23923 )

• 3 of 9 mice (33%) die from cleft secondary palates

craniofacial

absent incisors ( J:23923 )

cleft secondary palate ( J:23923 )

• 3 of 9 mice (33%) die from cleft secondary palates

vision/eye

eyelids open at birth ( J:23923 )

digestive/alimentary system

cleft secondary palate ( J:23923 )

• 3 of 9 mice (33%) die from cleft secondary palates

integument

absent vibrissae ( J:23923 )

growth/size/body

absent incisors ( J:23923 )

cleft secondary palate ( J:23923 )

• 3 of 9 mice (33%) die from cleft secondary palates

skeleton

absent incisors ( J:23923 )

Genotype
MGI:3758893

cx6

• Allelic Composition: Inhba^tm1Zuk/Inhba^tm3Zuk; Inhbb^tm1Jae/Inhbb^tm1Jae
• Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

reproductive system

female infertility ( J:125354 )

♀ • 3 of 5 females are infertile

reduced female fertility ( J:125354 )

♀ • the number of litters produced by females is reduced 43% (0.10+/-0.07 litters per month compared 0.89+/-0.04 litters per month in Inhba^tm1Zuk/Inhba^tm3Zuk mice)

♀ • however, there is no difference in the number of oocytes produced upon superovulation compared to Inhba^tm1Zuk/Inhba^tm3Zuk females

decreased litter size ( J:125354 )

• the number of pups per litter is decreased 33% relative (1.00+/-0.63 pups per litter compared to 7.78+/-0.48 pups per litter in Inhba^tm1Zuk/Inhba^tm3Zuk mice)