Analysis Tools
homeostasis/metabolism
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• increased amyloid beta 40 but not amyloid beta 42 on a high fat diet
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• streptozotocin (STZ) treatment leads to 3-fold higher level of blood glucose in mice fed a high fat diet
(J:100916)
• these high glucose levels persist for at least 12 weeks after STZ treatment
(J:100916)
• when fed a western style diet for 12 weeks
(J:130278)
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• when fed a western style diet for 12 weeks
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• streptozotocin (STZ) induced diabetes leads to blood cholesterol levels that are twice those of non-diabetic mice 6 weeks post-induction and three times greater 8 weeks post- induction
(J:100916)
• when fed a western style diet for 12 weeks, male mice exhibit a higher circulating cholesterol level than in Ldlrtm1Her Scd1ab-2J homozygotes
(J:130278)
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• when fed a high-cholesterol diet, NMR proton spectra of lipids indicates a level of photon intensity for HDL of 0.77 compared to 0.83 in wild-type mice
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• mice develop severe cholesterolemia when receiving a high fat diet from 6 to 30 weeks (elevated levels are detected at 6, 15, and 30 weeks)
(J:61287)
• seen at 3-4 months of age
(J:72027)
• 10 fold increase in total cholesterol on a high fat diet compared to a 150% increase for controls
(J:137264)
• 3 fold cholesterol elevation on a normal diet relative to controls
(J:137264)
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• slightly elevated at 3 and 8 months of age
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• when fed a high cholesterol diet, NMR proton spectra of lipids indicates a level of photon intensity for LDL of 0.88 compared to 0.84 in wild-type mice
(J:130794)
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• compared to in Ldlrtm1Her Scd1ab-2J homozygotes when fed a western style diet for 12 weeks
(J:130278)
• when fed a high cholesterol diet, NMR proton spectra of lipids indicates a level of photon intensity for VLDL of 0.92 compared to 0.88 in wild-type mice
(J:130794)
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• increased TNFalpha levels
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• when fed a western style diet for 12 weeks
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• livers exhibit slightly, but significantly, higher levels of cholesterol
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• seen at 3-4 months of age
(J:72027)
• when fed a western style diet for 12 weeks, female mice exhibit a higher circulating triglyceride level than in Ldlrtm1Her Scd1ab-2J homozygotes
(J:130278)
• elevated on a high fat diet
(J:137264)
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• compared to in Ldlrtm1Her Scd1ab-2J homozygotes when fed a western style diet for 12 weeks
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• when fed a western style diet for 12 weeks, mice exhibit a 5-fold higher hepatic triglyceride level than in Ldlrtm1Her Scd1ab-2J homozygotes
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adipose tissue
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• increased when fed a western style diet for 12 weeks
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• when fed a western style diet for 12 weeks
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growth/size/body
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• lower body weight on a low cholesterol diet than controls on any diet
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• when fed a western style diet for 12 weeks
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cardiovascular system
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• high-fat diet leads to atherosclerosis
(J:100916)
• STZ-induced diabetes leads to an almost 3-fold greater size in total lesion area in the aorta compared to non-diabetic Ldlr tm1Her homozyogotes
(J:100916)
• 4 weeks on the Western diet mice have lesions of small fatty streaks on the aorta
(J:110061)
• after 12 weeks on a high cholesterol diet, mice exhibit extensive intimal thickening and 60% to 80% of the aortic surface is sudanophilic unlike in wild-type mice
(J:130794)
• after 12 weeks on a high cholesterol diet, mice exhibit endothelial disruption and an accumulation of macrophage and foam cells at the site of atherosclerotic plaques
(J:130794)
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immune system
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• increased number of microglia in the hippocampus
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• increased TNFalpha levels
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liver/biliary system
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• livers exhibit slightly, but significantly, higher levels of cholesterol
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• when fed a western style diet for 12 weeks, mice exhibit a 5-fold higher hepatic triglyceride level than in Ldlrtm1Her Scd1ab-2J homozygotes
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• when fed a western style diet for 12 weeks
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behavior/neurological
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• take longer to reach the target site in a Morris water maze when fed a high cholesterol diet
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• deficient performance in a water radial arm maze regardless of the diet
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• perform better than controls on a hanging bar test
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• travel greater distances and spend more time in motion in an open field test
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nervous system
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• increased amyloid beta 40 but not amyloid beta 42 on a high fat diet
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• increased number of microglia in the hippocampus
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• increased numbers of reactive astrocytes
• further increase in reactive astrocytes on a high fat diet
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hematopoietic system
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• increased number of microglia in the hippocampus
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