About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Lifrtm1Imx
targeted mutation 1, Immunex
MGI:1857213
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Lifrtm1Imx/Lifrtm1Imx B6;129S7-Lifrtm1Imx/J MGI:6093713
hm2
Lifrtm1Imx/Lifrtm1Imx involves: 129P3/J * 129S7/SvEvBrd * C57BL/6 MGI:3768428
ht3
Lifrtm1Imx/Lifr+ B6;129S7-Lifrtm1Imx/J MGI:6094214


Genotype
MGI:6093713
hm1
Allelic
Composition
Lifrtm1Imx/Lifrtm1Imx
Genetic
Background
B6;129S7-Lifrtm1Imx/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lifrtm1Imx mutation (1 available); any Lifr mutation (59 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than the expected number (18.7% vs. 25%) of fetuses are seen at E18.5

growth/size/body
• small size at E18.5

endocrine/exocrine glands
• 100% of fetuses show a ligamentous tethering of the testis to the dorsal aorta impairing testicular descent, indicating cryptorchidism

renal/urinary system
• 70% of fetuses show ureter and kidney anomalies at E18.5, with 10% having severe and 60% having milder anomalies
• various abnormalities are seen in fetuses, including mild or severe hydronephrosis, a dilated renal collecting system, blind-ending ureter, hydroureter, microcystically dilated tubules, and ureter ectopia
• 10% of fetuses exhibit renal dysplasia
• reduction of glomerular number per kidney volume and glomerular volume
• E15.5 kidney shows a reduction of comma shaped bodies, premature glomeruli, and all glomerular developmental stages per kidney section
• in a subset of mutants
• kidney size is reduced at E15.5
• in a subset of mutants
• nephron number is reduced at E15.5
• reduction of the proximal, medial and distal ureteric lumen at E18.5
• hypertrophy of the distal ureter wall
• thickness of the ureteric smooth muscle layer and the urothelium are increased
• in a subset of mutants
• in a subset of mutants
• 10% of E18.5 fetuses exhibit severe hydroureter

reproductive system
• 100% of fetuses show a ligamentous tethering of the testis to the dorsal aorta impairing testicular descent, indicating cryptorchidism

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
CAKUT DOID:0080205 OMIM:PS610805
J:242320




Genotype
MGI:3768428
hm2
Allelic
Composition
Lifrtm1Imx/Lifrtm1Imx
Genetic
Background
involves: 129P3/J * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lifrtm1Imx mutation (1 available); any Lifr mutation (59 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice born vaginally or by Caesarian section die within hours of birth with no milk in their stomachs even when placed with foster mothers
• fewer than expected mice are recovered at E3.5

skeleton
• the number of osteoclasts is increased 6-fold (0.4+/-0.1 osteoclasts per mm3 compared to 0.3+/-0.2 osteoclasts per mm3 in wild-type mice)
• the number of osteoclast surfaces is increased 7-fold (4.1+/-0.6% compared to 0.6+/-0.3% in wild-type mice)
• bone density is lost at the proximal and distal ends of the long bones and metacarpi
• bone density is lost at the proximal and distal ends of the long bones and metacarpi
• bone density is lost at the proximal and distal ends of the long bones and metacarpi
• bones are osteopenic
• bone volume is reduced greater than 3-fold (4.8+/-0.6% compared to 13.4+/-0.9% in wild-type mice)

nervous system
• at E17.5 to E18.5, the number of GFAP+ astrocytes in the spine and brainstem is decreased compared to in wild-type mice
• E20.5 dorsal root ganglia neurons do not survive in culture when exposed to cytokines that rely on LIFR to mediate their signal unlike wild-type cells

embryo
• placenta contain more blood pooling than in wild-type mice and are edematous with large fluid-filled spaces and a lack of organization into distinct spongio- and labyrinthine trophoblast zones
• at E17.5, placenta contain excess fibrin in association with the blood lacunae and marginated leukocytes can be detected in some of these enlarged maternal blood spaces
• at E17.5, the lacy appearance of the normal labyrinthine placenta is lost
• however, fetal hematopoiesis is normal

homeostasis/metabolism
• at E18.5, fetal livers contain higher stores of glycogen than in wild-type mice

growth/size/body
• some mice are smaller at birth

immune system
• the number of osteoclasts is increased 6-fold (0.4+/-0.1 osteoclasts per mm3 compared to 0.3+/-0.2 osteoclasts per mm3 in wild-type mice)
• the number of osteoclast surfaces is increased 7-fold (4.1+/-0.6% compared to 0.6+/-0.3% in wild-type mice)

hematopoietic system
• the number of osteoclasts is increased 6-fold (0.4+/-0.1 osteoclasts per mm3 compared to 0.3+/-0.2 osteoclasts per mm3 in wild-type mice)
• the number of osteoclast surfaces is increased 7-fold (4.1+/-0.6% compared to 0.6+/-0.3% in wild-type mice)

limbs/digits/tail
• bone density is lost at the proximal and distal ends of the long bones and metacarpi

liver/biliary system
• at E18.5, fetal livers contain higher stores of glycogen than in wild-type mice




Genotype
MGI:6094214
ht3
Allelic
Composition
Lifrtm1Imx/Lifr+
Genetic
Background
B6;129S7-Lifrtm1Imx/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lifrtm1Imx mutation (1 available); any Lifr mutation (59 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 42.5% of fetuses show a ligamentous tethering of the testis to the dorsal aorta impairing testicular descent, indicating cryptorchidism

renal/urinary system
• reduction of the proximal, medial and distal ureteric lumen at E18.5, but to a lesser extent than in homozygotes
• 5% of E18.5 fetuses exhibit severe hydroureter

reproductive system
• 42.5% of fetuses show a ligamentous tethering of the testis to the dorsal aorta impairing testicular descent, indicating cryptorchidism





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory