All Phenotypes Lta<tm1Dch> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lta^tm1Dch/Lta^tm1Dch	B6.129S2-Lta^tm1Dch	MGI:2182138
hm2	Lta^tm1Dch/Lta^tm1Dch	B6.129S2-Lta^tm1Dch/J	MGI:3702634
hm3	Lta^tm1Dch/Lta^tm1Dch	involves: 129S2/SvPas	MGI:5013460
hm4	Lta^tm1Dch/Lta^tm1Dch	involves: 129S2/SvPas * C57BL/6	MGI:3580160
hm5	Lta^tm1Dch/Lta^tm1Dch	involves: 129S2/SvPas * C57BL/6J	MGI:4867652
cx6	Lta^tm1Dch/Lta^tm1Dch Rorc^tm2Litt/Rorc⁺	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	MGI:3054104
cx7	Lta^tm1Dch/Lta^tm1Dch Tnfsf14^tm1Lpc/Tnfsf14^tm1Lpc	involves: 129S2/SvPas * 129X1/SvJ	MGI:5013461
cx8	Lta^tm1Dch/Lta^tm1Dch Tg(Ins2-Cxcl13)1Cys/0	involves: 129S2/SvPas * C57BL/6 * DBA/2	MGI:3689371
cx9	Lta^tm1Dch/Lta^tm1Dch Tg(Igk-Lta/Ltb)4Cys/0	involves: 129S2/SvPas * C57BL/6J * DBA/2J	MGI:3702635

Allelic Composition	Lta^tm1Dch/Lta^tm1Dch
Genetic Background	B6.129S2-Lta^tm1Dch

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lta^tm1Dch mutation (2 available); any Lta mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal class switch recombination ( J:80616 )

• specific IgG antibodies are almost undetectable in SRBC immunized mutants, indicating defective class switching

increased leukocyte cell number ( J:80616 )

• 2- to 3- fold increase in leukocyte count in spleen, blood, and peritoneal cavity

abnormal spleen morphology ( J:80616 )

• mixed T- and B-cell areas and the boundary between white and red pulp is less defined

decreased spleen B cell follicle number ( J:80616 )

• absence of polarized B-cell follicles

absent spleen germinal center ( J:80616 )

absent spleen marginal zone ( J:80616 )

decreased spleen white pulp amount ( J:80616 )

• gradual reduction of white pulp size

absent Peyer's patches ( J:80616 )

• not grossly detectable

abnormal mucosa-associated lymphoid tissue morphology ( J:95222 )

• nasal-associated lymphoid tissue poorly developed and hypocellular

abnormal immune serum protein physiology ( J:80616 )

decreased IgG level ( J:80616 )

• defecient IgG antibody production

increased IgM level ( J:80616 )

• total IgM levels are increased to about 2-times that of wild-type, due to an increase in number of IgM producing plasma cells in the spleen

abnormal cytokine secretion ( J:95222 )

• chemokine expression is essentially absent

• no Ifn-gamma produced in nasal-associated lymphoid tissue but it is found in the spleen

hematopoietic system

abnormal class switch recombination ( J:80616 )

• specific IgG antibodies are almost undetectable in SRBC immunized mutants, indicating defective class switching

increased leukocyte cell number ( J:80616 )

• 2- to 3- fold increase in leukocyte count in spleen, blood, and peritoneal cavity

abnormal spleen morphology ( J:80616 )

• mixed T- and B-cell areas and the boundary between white and red pulp is less defined

decreased spleen B cell follicle number ( J:80616 )

• absence of polarized B-cell follicles

absent spleen germinal center ( J:80616 )

absent spleen marginal zone ( J:80616 )

decreased spleen white pulp amount ( J:80616 )

• gradual reduction of white pulp size

decreased IgG level ( J:80616 )

• defecient IgG antibody production

increased IgM level ( J:80616 )

• total IgM levels are increased to about 2-times that of wild-type, due to an increase in number of IgM producing plasma cells in the spleen

Allelic Composition	Lta^tm1Dch/Lta^tm1Dch
Genetic Background	B6.129S2-Lta^tm1Dch/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lta^tm1Dch mutation (2 available); any Lta mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal lymph organ development ( J:73100 )

Allelic Composition	Lta^tm1Dch/Lta^tm1Dch
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lta^tm1Dch mutation (2 available); any Lta mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal thymus epithelium morphology ( J:173115 )

• disorganized medullary thymic epithelial cells

abnormal thymus medulla morphology ( J:173115 )

• medullary areas are smaller in size and less frequently connected to each other than in wild-type mice

small thymus medulla ( J:173115 )

abnormal lymphocyte morphology ( J:173115 )

• mice exhibit accumulation of lymphoid cell aggregates (B220+, CD4+, and CD8+ lymphocytes) in the liver and lung unlike in wild-type mice

hematopoietic system

abnormal thymus epithelium morphology ( J:173115 )

• disorganized medullary thymic epithelial cells

abnormal thymus medulla morphology ( J:173115 )

• medullary areas are smaller in size and less frequently connected to each other than in wild-type mice

small thymus medulla ( J:173115 )

abnormal lymphocyte morphology ( J:173115 )

• mice exhibit accumulation of lymphoid cell aggregates (B220+, CD4+, and CD8+ lymphocytes) in the liver and lung unlike in wild-type mice

endocrine/exocrine glands

abnormal thymus epithelium morphology ( J:173115 )

• disorganized medullary thymic epithelial cells

abnormal thymus medulla morphology ( J:173115 )

• medullary areas are smaller in size and less frequently connected to each other than in wild-type mice

small thymus medulla ( J:173115 )

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:109621 )

• in response to LPS and D-GalN administration, percentage of severely moribund mice is 0 at 7 hours; 3/7 mice are severely moribund at 8 hours

immune system

abnormal class switch recombination ( J:109621 )

• 19 days after immunization with OVA, mice display an isotype switch to IgG from IgM that is several fold decreased compared to wild-type

abnormal leukocyte cell number ( J:17976 )

decreased T cell number ( J:17976 )

• in the spleen

increased leukocyte cell number ( J:17976 )

• nearly 3 fold increase

• neutrophil, monocyte, platelet counts normal

increased B cell number ( J:17976 )

• 4 fold increase in B cell numbers

• 30% increase in IgM positive and B220 positive B lymphocytes

abnormal spleen morphology ( J:17976 , J:39746 )

• mice exhibit extensive disorganization (J:39746)

absent spleen marginal zone ( J:17976 )

• loss of a distinct marginal zone

abnormal spleen periarteriolar lymphoid sheath morphology ( J:17976 )

decreased spleen white pulp amount ( J:109621 )

• percentage of splenic white pulp is lower than in wild-type, Ltb nulls and Lta^tm1.1Sned but higher than Ltb, Ltbr or Ltb/Tnf/Lta knockouts

absent Peyer's patches ( J:17976 )

• not grossly detectable

abnormal lymph node morphology ( J:17976 )

• lack para-aortic lymph nodes

absent mesenteric lymph nodes ( J:17976 , J:39746 )

abnormal lymph node primary follicle morphology ( J:109621 )

• only occasional BP-3 cells are found in some lymphoid follicles

absent axillary lymph nodes ( J:17976 )

absent cervical lymph nodes ( J:17976 )

absent inguinal lymph nodes ( J:17976 )

absent popliteal lymph nodes ( J:17976 )

abnormal humoral immune response ( J:39746 )

• in response to stimulation with sheep red blood cells (SRBC), mice fail to produce anti-SRBC IgG at day 6 and only produce a negligible amount by day 15 unlike wild-type mice

decreased interferon-gamma secretion ( J:109621 )

• in culture, OVA-specific Ifng production from purified CD4+ T cells is decreased 2-fold compared to Lta^tm1.1Sned

decreased tumor necrosis factor secretion ( J:109621 )

• in response to LPS, mice demonstrate a 10-fold decrease in production of TNF compared to wild-type or Lta^tm1.1Sned

• both bone marrow derived macrophages and neutrophils fail to produce normal levels of TNF when stimulated

hematopoietic system

abnormal class switch recombination ( J:109621 )

• 19 days after immunization with OVA, mice display an isotype switch to IgG from IgM that is several fold decreased compared to wild-type

abnormal leukocyte cell number ( J:17976 )

decreased T cell number ( J:17976 )

• in the spleen

increased leukocyte cell number ( J:17976 )

• nearly 3 fold increase

• neutrophil, monocyte, platelet counts normal

increased B cell number ( J:17976 )

• 4 fold increase in B cell numbers

• 30% increase in IgM positive and B220 positive B lymphocytes

abnormal spleen morphology ( J:17976 , J:39746 )

• mice exhibit extensive disorganization (J:39746)

absent spleen marginal zone ( J:17976 )

• loss of a distinct marginal zone

abnormal spleen periarteriolar lymphoid sheath morphology ( J:17976 )

decreased spleen white pulp amount ( J:109621 )

• percentage of splenic white pulp is lower than in wild-type, Ltb nulls and Lta^tm1.1Sned but higher than Ltb, Ltbr or Ltb/Tnf/Lta knockouts

Allelic Composition	Lta^tm1Dch/Lta^tm1Dch
Genetic Background	involves: 129S2/SvPas * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lta^tm1Dch mutation (2 available); any Lta mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

liver/biliary system phenotype ( J:112797 )

N	• mice fed a high cholesterol diet do not develop hepatic steatosis unlike Lta/Tnf^tm1Eug homozygotes

Allelic Composition	Lta^tm1Dch/Lta^tm1Dch Rorc^tm2Litt/Rorc⁺
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lta^tm1Dch mutation (2 available); any Lta mutation (17 available)
Rorc^tm2Litt mutation (2 available); any Rorc mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal gut-associated lymphoid tissue morphology ( J:91566 )

• mature intestinal cryptopatches fail to form

Allelic Composition	Lta^tm1Dch/Lta^tm1Dch Tnfsf14^tm1Lpc/Tnfsf14^tm1Lpc
Genetic Background	involves: 129S2/SvPas * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lta^tm1Dch mutation (2 available); any Lta mutation (17 available)
Tnfsf14^tm1Lpc mutation (0 available); any Tnfsf14 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal thymus epithelium morphology ( J:173115 )

• more disorganized medullary thymic epithelial cells than in Lta^tm1Dch homozygotes

small thymus medulla ( J:173115 )

• smaller than in Lta^tm1Dch homozygotes

abnormal lymphocyte morphology ( J:173115 )

• mice exhibit accumulation of lymphoid cell aggregates (B220+, CD4+, and CD8+ lymphocytes) in the liver and lung unlike in wild-type mice

immune system

abnormal thymus epithelium morphology ( J:173115 )

• more disorganized medullary thymic epithelial cells than in Lta^tm1Dch homozygotes

small thymus medulla ( J:173115 )

• smaller than in Lta^tm1Dch homozygotes

abnormal lymphocyte morphology ( J:173115 )

• mice exhibit accumulation of lymphoid cell aggregates (B220+, CD4+, and CD8+ lymphocytes) in the liver and lung unlike in wild-type mice

endocrine/exocrine glands

abnormal thymus epithelium morphology ( J:173115 )

• more disorganized medullary thymic epithelial cells than in Lta^tm1Dch homozygotes

small thymus medulla ( J:173115 )

• smaller than in Lta^tm1Dch homozygotes

Allelic Composition	Lta^tm1Dch/Lta^tm1Dch Tg(Ins2-Cxcl13)1Cys/0
Genetic Background	involves: 129S2/SvPas * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lta^tm1Dch mutation (2 available); any Lta mutation (17 available)
Tg(Ins2-Cxcl13)1Cys mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:110548 )

• frequency and size of pancreatic infiltrates is same as in wild-type transgenic littermates

Allelic Composition	Lta^tm1Dch/Lta^tm1Dch Tg(Igk-Lta/Ltb)4Cys/0
Genetic Background	involves: 129S2/SvPas * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lta^tm1Dch mutation (2 available); any Lta mutation (17 available)
Tg(Igk-Lta/Ltb)4Cys mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:73100 )

N	• spleen architecture is largely restored compared to Lta-deficient mice; extensive networks of T zone stromal cells are observed • splenic dendritic cell numbers are restored

abnormal spleen morphology ( J:73100 )

• although T zone stromal areas are extensive compared to Lta-deficient mice, distribution of gp38+ staining differs from wild-type with a higher concentration of positive cells near the boundary of the B and T zones

abnormal lymph organ development ( J:73100 )

• transgene expression does not restore lymph node or Peyer's patch development in Lta-deficient mice

hematopoietic system

abnormal spleen morphology ( J:73100 )

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